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Clobetasol
What ratio of T[S]2 to T[SH]2 is growth inhibitory or lethal to the cell, but no major changes in thiol levels were observed when TryR levels fell to about 90% of controls. Nonetheless, to take a worse case scenario, where half of the T[SH]2 must be converted to T[S]2 before death occurs, then it can be easily calculated that competitive inhibitors with Ki values in the nanomolar range will be required to maintain inhibition at 90% in response to accumulating T[S]2. This is by no means insurmountable, but suggests design of irreversible inhibitors may be a better strategy for drug development!
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Lipid-lowering drug use and cardiovascular events after myocardial infarction The benefits of lipid lowering therapy for the secondary prevention of myocardial infarction are now well established. The risk of events has not, however, been compared for statin and non-statin lipid-lowering drugs. Also, there is uncertainty as to whether patients in normal clinical practice gain a similar benefit in terms of reduction of risk of cardiovascular events as patients in randomised, controlled trials. This study looked at patients who had had an MI and survived for more than six months after hospitalisation. Pharmacy records were used to assess lipid lowering drug therapy taken during the first six months post-MI. Results are summarised in the table, which shows the relative risk of events compared with a control group 1, 263 patients ; who did not receive lipid lowering therapy.
28. Franz TJ, Parsell DA, Halualani RM, Hannigan JF, Kalbach JP, Harkonen WS. Betamethasone valerate foam 0.12%: a novel vehicle with enhanced delivery and efficacy. Int J Dermatol 1999; 38: 628-32. Feldman SR, Ravis SM, Fleischer AB Jr, McMichael A, Jones E, Kaplan R, et al. Betamethasone valerate in foam vehicle is effective with both daily and twice a day dosing: a singleblind, open-label study in the treatment of scalp psoriasis. J Cutan Med Surg 2001; 5: 386-9. Lebwohl M, Sherer D, Washenik K, Krueger GG, Menter A, Koo J, et al. A randomized, double-blind, placebo-controlled study of clobetasol propionate 0.05% foam in the treatment of nonscalp psoriasis. Int J Dermatol 2002; 41: 269-74. Stein LF, Sherr A, Solodkina G, Gottlieb AB, Chaudhari U. Betamethasone valerate foam for treatment of nonscalp psoriasis. J Cutan Med Surg 2001; 5: 303-7.
Patent agent: howson and howson cathy kodroff - ft washington, pa, us patent inventors: sripriya venkata ramana rao , syed shah , hanumantharao tatapudy , richard saunders , mahdi fawzi , arwinder nagi , shailesh singh , suwon hasan applicaton #: 20070042033 class: 424451000 uspto ; related patents: drug, bio-affecting and body treating compositions , preparations characterized by special physical form , capsules e, g.
Although some dermatologic diseases have decreased markedly in frequency in the potent antiretroviral therapy era, other conditions remain common. Among patients with low CD4 + cell counts who are not on or not adherent to antiretroviral therapy, notable conditions include psoriasis, photodermatitis, prurigo nodularis, molluscum, and adverse drug reactions. Conditions that remain relatively common despite adequate antiretroviral therapy include eczema, xerosis, warts, and Kaposi's sarcoma. Disorders that are associated with immune reconstitution under potent antiretroviral therapy include acne, staphylococcal infections, and erythema nodosum. In addition, HIV and hepatitis C virus HCV ; coinfection is associated with a number of skin disorders. This article summarizes a presentation on dermatologic manifestations of HIV disease by Toby A. Maurer, MD, at the 8th Annual Clinical Conference for Ryan White CARE Act clinicians in New Orleans in June 2005. In many locales in the United States, the frequency of dermatologic diseases in HIV-infected patients--including seborrheic dermatitis, fungal diseases, psoriasis, and opportunistic infections with skin manifestations-- has declined with the use of potent antiretroviral therapy. However, dermatologic disorders remain common in the HIV-infected population. occurs or in cases of complex or more severe psoriasis, treatment with the retinoid agent acitretin at 10 to mg d can be considered; it should be noted that this agent is associated with increases in triglycerides and cholesterol. Psoriasis in HIV disease can have unusual presentations. Figure 1 shows inverse psoriasis of the feet and underarm, differing from the common presentation of psoriasis on extensor surfaces. Photodermatitis Figure 2 shows photodermatitis of the face, the "vee" of the neck, and the arm and hand, with the typical darkening of skin that is exposed to sun. Persons with background pigment of the skin ie, people of color ; are more photosensitive than persons without background pigment in the skin. HIV infection itself is photosensitizing, and patients with low CD4 + cell counts may be receiving photosensitizing drugs such as trimethoprim sulfamethoxazole TMP SMX ; . Antiretroviral therapy allows patients to go off photosensitizing drugs and also decreases the reaction through immune reconstitution. Treatment includes sunscreen, potent topical steroids eg, clobetasol ; , lubricants, and antihistamines. The tricyclic doxepin 25 mg qhs ; is useful for its strong antihistamine effects. 149 Prurigo nodularis Figure 3 shows prurigo nodularis "itchy bumps" ; of the arms and trunk. The disorder, which may have a photocomponent, is more frequently seen in patients with CD4 + cell counts below 50 L and is more common in persons of color. Patients are consumed by itching, which is not relieved with antihistamines. Institution of antiretroviral therapy is helpful in resolving the condition. Potent topical steroids should be used, and thalidomide is effective when it is started at a dose of 50 mg d and titrated for response rarely above 100 mg d ; . Careful monitoring for development of peripheral neuropathies is suggested. In addition, thalidomide is a teratogen and special precautions need to be taken in women of childbearing potential. Figure 4 shows a condition characterized by numerous papules smaller than those typically seen in prurigo nodularis; for years, this condition has been unhelpfully described as "pruritic eruption of HIV." This is a common condition in areas of Africa, and a study was recently performed in Ugandan patients to determine the cause of the disorder Resneck, JAMA, 2004 ; . Of 102 lesion biopsies, 86 showed evidence of bug bites. A lower CD4 + cell count was significantly associated with greater severity of eruption, and the condition appeared to improve in patients started on antiretroviral therapy. The condition may thus represent hypersensitivity to bug bites secondary to immune deficiency. Molluscum Figure 5 shows severe facial molluscum. Molluscum is frequently seen in HIV-infected young women and men of any age who are not on antiretroviral therapy or are not adherent to their regimen. Its appearance fairly assures and clotrimazole.
UNICEF WHO, Joint Committee on Health Policy. Strategic approach to operationalizing selected end-decade goals: reduction of iron deficiency anemia. New York: Unicef, 1995. JCHP 30 95 4.5. ; 8 WHO Collaborative Study Team on the Role of Breastfeeding on the Prevention of Infant Mortality. How much does breastfeeding protect against infant and child mortality due to infectious diseases? A pooled analysis of six studies from less developed countries. Lancet 2000; 355: 451-5. Mbori-Ngacha D, Nduati R, John G, Reilly M, Richardson B, Mwatha A, et al. Morbidity and mortality in breastfed and formula-fed infants of HIV1-Infecterd women. A randomized clinical trial. JAMA 2001; 286: 2413-20. Coutsoudis A, Pillay K, Kuhn L, Spooner E, Tsai WY, Coovadia HM, et al. Method of feeding and transmission of HIV-1 from mothers to children by 15 months of age. AIDS 2001; 15: 379-87. World Health Organization. The optimal duration of exclusive breastfeeding. Report of an expert consultation. Geneva, 28-31 March 2001 WHO FCH CAH 01.24 ; . who.int child-adolescent-health New Publications NUTRITION WHO CAH 01 24 accessed 23 Aug 2002. ; 12 Morrow AL, Guerrero L, Shults J, Calva JJ, Lutter C, Bravo J, et al. Efficacy of home-based peer counseling to promote exclusive breastfeeding: a randomized controlled trial. Lancet 1999; 353: 1226-31.
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Save skin cap all the information regarding the skin cap controversy save skin cap skin cap user's opinions skin cap user's opinions 2 skin cap user's opinions 3 skin cap user's opinions 4 skin cap user's opinions 5 skin cap user's opinions 6 skin cap user's opinions 7 skin cap user's opinions 8 august 11, 1997 dear dermatologists as the innovater of temovate brand clobetasol propionate and your partner in dermatological care, glaxo dermatology is providing you with the following important information about a product called skin cap and cutivate.
TABLE 3. AGENTS PENDING FDA APPROVAL Generic Name Approvable Agents AF0150 perfluorohexane emulsion ; Ckobetasol propionate Doxercalciferol Duloxetine Flunisolide Imavist Alliance Pharmaceutical ; Olux Connetics Corp. ; Hectorol Bone Care International ; Cymbalta Lilly ; Aerospan Forest Laboratories ; Ultrasound contrast agent 8 01 Brand Name Company ; Indication Comment.
SIDE CHAIRS by Robert W. Irwin. Solid walnut Itelien cle, ign suitable for needlepoint or we offer a IllTg9 selection of coverings to choose from. Were $96.00: Now $24.50 each ARM CHAIRS made of fruitwood. English de~ sign by Robert W. Irwinof Queen Anne style. Suitable for Needlepoint or select from our coverings. Were $60.00. Now $19.50 each SIDE CHAIRS of ancestral oak. Beautifully carved panel back. Coverings to be selected. Were $34.00. Now $14.00 each FRENCH PROVENCIAL WALLBOARD, 54 inches long. of beechwood, antique finish by Eber Irwin. WlJ.S $70.00. Now $19.50 HAND CARVED WALL CABINET. G, I'SII.S Gibbons design reproduced by Robert W. Irwin. Yery beautifully carved. Was $1, 500.00. Now $295.00 '; 4: RtiA CHAIRS, beautifully carved of solid blaek walnut. louis XV design. Reprodueed by Rob. ert Irwin. Antique velvet. Was $243.00 . Now $87.50 eac: h ARM CHAIRS, genuine mahogany, deep spring seats, Adam styling with shield back of intricate design. Reproduced by Robert W. Irwin. Was $65.00. Now $24.50 each seT UP BRIDGE TABLE, fruitwood, Direetoire design by Robart W. Irwin. Was $125.00. No': $49.50 IMPORTED CARVED W.s $175.00. CAMPHORWOOD CHEST. 10"' ""wors. Now $89.50 and cyproheptadine.
Please refer to Introduction for additional information on abbreviations. A Specialty Group A GP Generic Preferred Substitution AL Age Limit NF Nonformulary B Specialty Group B PA Prior Authorization EST Electronic Step Therapy QL Quantity Limit GL Gender Limit TL Therapy Limit healthnet 37.
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The ability to use this medication more conveniently is going to play a big role in keeping people at work and keeping them involved in their lives and diamicron.
Dermatol Symp Proc 2004; 9: 7378. Andrade M, Jackow CM, Dahm N, Hordinsky M, Reveille JD, Dovic M. Alopecia areata in families: association with the HLA locus. J Invest Dermatol Symp Proc 1999; 4: 220223. Colombe BW, Lou CD, Vera HP. The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. J Invest Dermatol Symp Proc 1999; 4: 216218. Nanda A, Alsaleh QA, Al-Hasawi F, Al-Muzairai I. Thyroid function, autoantibodies, and HLA tissue typing in children with alopecia areata. Pediatr Dermatol 2002; 19: 486491. Whiting DA. Histopathologic features in alopecia areata. Arch Dermatol 2003; 139: 15551559. Wade MS, Sinclair RD. Persistent depigmented growth after alopecia areata. J Acad Dermatol 2002; 46: 619620. Thiedke CC. Alopecia in women. Fam Physician 2003; 67: 10071014. Freyschmidt-Paul P, Happle R, McElwee KJ, Hoffmann R. Alopecia areata: treatment of today and tomorrow. J Invest Dermatol Symp Proc 2003; 8: 1217. Tosti A, Piraccini BM, Pazzaglia M, Vincenzi C. Cloebtasol propionate 0.05% under occlusion in the treatment of alopecia totalis universalis. J Acad Dermatol 2003; 49: 9698. Alabdulkareem AS, Abahussein AA, Okoro A. Severe alopecia areata treated with systemic corticosteroids. Int J Dermatol 1998; 37: 622624. Weise K, Kretzschmar L, John SM, Hamm H. Topical immunotherapy in alopecia areata: anamnestic and clinical criteria of prognostic significance. Dermatology 1996; 192: 129133. Gundogan C, Greve B, Raulin C. Treatment of alopecia areata with the 308-nm xenon chloride excimer laser: case report of two successful treatments with the excimer laser. Lasers Surg Med 2004; 34: 8690. ADDRESS: Nicole C. Dombrowski, DO, Internal Medicine Center, Akron City Hospital, 55 Arch Street, Suite 1B, Akron, OH 44304.
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In animal models of Parkinson's disease, neuropathic pain, diarrhea, intestinal inflammation, and colitis. It has been reported that cannabinoid receptor expression is higher in some cancer cells than in normal cells75, 187, 189 and also that it sometimes correlates with the degree of cancer cell malignancy.131 It will be important to identify other disorders in which cannabinoid receptor upregulation is confined entirely or mainly to tissues in which activation of cannabinoid receptors is expected to alleviate symptoms or to inhibit disease progression. This is because such a pattern of receptor upregulation may well improve the selectivity of cannabinoid receptor agonists by enhancing their potency for the production of sought-after effects more than their potency for the production of unwanted effects. Selectivity improvements resulting from an uneven cannabinoid receptor upregulation of this kind are expected to be most evident for partial agonists such as 9-THC and cannabinol. Thus although an increase in receptor density will augment the potencies of both full and partial agonists, it will often also increase the size of the maximal response to a partial agonist without affecting the maximal response to a full agonist. This difference between the pharmacology of full and partial agonists can be seen in results from experiments with cannabinol and CP55940 in which an increase in the intestinal expression of CB1 receptors and intestinal inflammation ; had been induced in mice by oral croton oil and in which the measured response was cannabinoid-induced CB1 receptor-mediated inhibition of upper gastrointestinal transit of a charcoal suspension.117 Thus, it was found that this increase in CB1 expression level was accompanied not only by a leftward shift in the log dose-response curve of cannabinol but also by an increase in the size of the maximal effect of this partial agonist. In contrast, the higher efficacy agonist, CP55940, exhibited an increase in its potency but no change in its maximal effect. The upregulation of a subpopulation of cannabinoid receptors that alleviates symptoms or inhibits disease progression when activated should of course also augment protective effects of endogenously released endocannabinoids and hence of FAAH inhibitors and other types of indirect agonist. For anandamide, cannabinoid receptor upregulation is likely to produce an increase in maximal effect as well as potency as this endocannabinoid is a CB1 and CB2 receptor partial agonist. On the other hand, 2-arachidonoyl glycerol would be expected to exhibit only an increase in potency as it has been found in several investigations to exhibit much higher CB1 and CB2 receptor efficacy than anandamide Endocannabinoids section ; . Tolerance can develop to CB1 receptor agonists and there is evidence that this is often caused by a reduction in CB1 receptor density or signaling.211 Consequently, it is tempting to speculate that if a particular disease causes an increase and diclofenac.
Decreases inflammation: suppress migration of PMN& reducing capillary permeability Topical Triamcinolone 0.1% Oracort E, ; Clobetzsol propionate 0.05% Dermovate ; Drying or wiping mucous membrane prior to application.
It is not yet known if being on the drug for a longer period of time causes damage and dimenhydrinate.
The treated skin area should more̷ posted in clboetasol no comments » caution should be exercised when either coobetasol propionate gel.
But they should consult their physician, especially if they have parkinson's disease, take medications for depression, or have heart disease and ditropan.
149; it is important to use cloobetasol topical regularly to get the most benefit.
There are approximately 600, 000 civil aviation pilots licensed by the FAA worldwide. These pilots require physical examination for medical certification at a frequency ranging from twice a year to once every three years, depending on the class of the examination and the age of the pilot. Between 450, 000 to 470, 000 FAA medical examinations are performed annually by a group of 5, 000 FAA-designated Aviation Medical Examiners AMEs ; located in the U.S. and in 90 countries around the world. This presentation will outline the mandatory requirements for obtaining and maintaining FAA AME designation. Demographics of the present AME population will be discussed. Special emphasis will be given to the discussion of critical issues involving the management of international AMEs from the and dramamine.
One of the last frontiers to understand is the role of trauma and recovery for survivors who are diagnosed with serious, persistent mental illness SMI ; . Riverview Hospital found high rates of disclosures of physical and sexual abuse in a sampling of 72 women and men in hospital.2 A review of studies of women diagnosed with SMI compared a lifetime history of physical or sexual abuse among this group 51 to 97% ; with histories in general population studies of 14 to 34%.3 Dr. Marina Morrow of the BC Centre of Excellence for Women's Health recently documented that while "an awareness of violence and abuse is critical for understanding mental illness" and supporting recovery, it has been "routinely overlooked" in our province.4 Many staff have not been trained in this area. Only a few mental health teams have an abuse resource worker, who cannot meet all the demand for services. At Riverview Hospital in 2000, the Vulnerable Patients Task Group was organized to address some of this need. I was invited to.
Amino acids 4.25% d10w, d20w, d25w amino acids 4.25% d5w; 5% d15w, d20w, d25w, 2.75% d5w amino acids 4.25% cal lytes d25w amino acids 4.25% cal lytes d5w, amino acids 5%, amino acids 2.75% amino acids 15% sulindac clobetasol propionate emoll clobetasol propionate, CLOBEVATE, CORMAX, EMBELINE CLOBEX, OLUX, TEMOVATE clobetasol propionate emoll, CLOBETASOL E, EMBELINE E, OLUX-E clobetasol propionate clobetasol propionate CLODERM clocortolone pivalate CLOLAR clofarabine clomipramine hcl ANAFRANIL clonidine hcl CATAPRES-TTS DURACLON CATAPRES CLORPRES 35 and enalapril and clobetasol.
Daily antidandruff shampoo and intermittent steroid solution foam i.e., clobetasol [Temovate] 0.05% solution, foam, or shampoo.
Since it works so efficiently for a majority and can be prescribed obstetrically without food and drug administration approval, there's less motivation for learning why for some women the drug has a catastrophic effect and escitalopram.
I've read that the drug was originally developed as a weight loss drug, then they realized it was really helping people with blood sugar levels incidentally.
A mail order program is available to UPMC Health Plan Members. The Member can receive an extended supply of maintenance drugs for a reduced price. When filled through UPMC Health Plan pharmacy mail order program, Members will be covered for up to a 90-day supply of Prescription Drugs after an initial retail or mail order 30-day supply ; for the designated mail order Copayment charge per prescription.
5. How to draw the retrospective sample of patient encounters if needed ; : Procedures for assembling the lists that comprise the sample frame, and listing cases; Linking other necessary data on drugs for the encounters if needed. 6. Field practice: Visit and collect complete set of data in one region outside of sample; Complete all forms. 7. Final discussion: Review experiences of field test and address concerns and questions; Revise data collection forms if and as needed; Assign data collectors to working teams: Finalize data collection plan and organization of work schedules, transport, communication.
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5.1 Animal data No data were available to the Working Group. 5.2 Human data Although ten cases of liver-cell tumours have been reported in patients with aplastic anaemia, Fanconi's anaemia or paroxysmal nocturnal haemoglobinuria treated for long periods with oxymetholone alone or in combination with other androgenic drugs, a causal relationship cannot be established. The increased risk of developing liver-cell tumours could be related to hepatic damage known to be caused by oxymetholone. On the other hand, patients with congenital anaemias many have an intrinsically higher risk of developing tumours; this risk many become manifest during the extended survival resulting from administration of the drug. Subsequent evaluation: Suppl. 7 1987 ; Androgenic Anabolic ; Steroids, for example, clobetasol propionate cream uses.
Males are more likely to report non-medical use of prescription stimulants than females Teter et al., 2005; McCabe et al., 2005; Low and Gendaszek, 2002 ; . White students report higher rates of nonprescription stimulant use than Asian or AfricanAmerican students McCabe et al., 2005 ; . Fraternity or sorority members are also more likely to report non-prescription stimulant use compared to non-members McCabe, Teter, Boyd, in press; Teter et al., 2005 ; . College students with lower GPAs more likely to report non-prescription use of these substances McCabe et al., 2005 ; . College students who use prescription stimulants without a prescription were also significantly more likely to report heavy episodic drinking, marijuana use, as well as ecstasy, cocaine, and opiate use McCabe, 2005; Teter, et al., 2003 and clotrimazole!
1 To whom correspondence should be addressed at Department of Cell Biology and Biochemistry, 3601 4th Street, Texas Tech University Health Sciences Center, Lubbock, TX 79430. E-mail: jim.hutson ttuhsc.
Tinuing CsA 3 of 149 ; . In one case, the cause of death was documented myocardial infarction; two patients were found dead at home, presumably as a result of fatal myocardial infarction Table 3 ; . Treatment failure, defined as changes in immunosuppressive therapy or reinstitution of the discontinued drug, resulted from various causes Table 4 ; . In the CsA withdrawal group, calcineurin inhibitors were mostly restarted after acute rejection episodes requiring antiT cell therapy protocol driven ; . Pred withdrawal was uneventful for almost all patients.
TOPICAL CORTICOSTEROIDS Group I Very High Potency augmented betamethasone dipropionate gel lotion oint, 0.05% Diprolene ; clobetasol cream oint gel soln, 0.05% Temovate ; CLOBEX SPRAY LOTION SHAMPOO, dermatologists only diflorasone diacetate oint, 0.05% Psorcon ; halobetasol prop cream oint, 0.05% Ultravate ; Group II High Potency amcinonide cream oint lotion, 0.1% Cyclocort ; augmented betamethasone dipropionate cream, 0.05% Diprolene AF ; betamethasone dipropionate cream oint gel, 0.05% Diprosone, Diprolene ; betamethasone valerate oint, 0.1% Valisone ; desoximetasone cream oint, 0.25%, gel, 0.05% Topicort ; diflorasone diacetate cream oint, 0.05% Psorcon ; fluocinonide cream oint gel soln, 0.05% Lidex ; TACLONEX, dermatologists only triamcinolone cream oint lotion, 0.5% Aristocort ; Group III Medium Potency betamethasone dipropionate lotion, 0.05% Diprosone.
The nasal spray is formulated by compounding pharmacists.
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Oral Toxicity Inhalation Toxicity Skin Effects Eye Effects Target Organ Effects Sensitisation Genetic Toxicity Carcinogenicity Reproductive Effects Pharmacological Effects Not expected to be toxic following ingestion. No studies have been conducted. Irritation is not expected following direct contact. Irritation is not expected following direct contact with eyes. Adverse effects might occur in the following organ s ; following overexposure: central nervous system. Sensitisation allergic skin reaction ; is not expected. Not expected to be genotoxic under occupational exposure conditions. No components are listed as carcinogens by GSK, IARC, NTP or US OSHA. Not expected to produce adverse effects on fertility or development under occupational exposure conditions. This preparation contains ingredient s ; with the following activity: a selective serotonin re-uptake inhibitor. Adverse effects of overexposure might include: drowsiness; dizziness; dry mouth; diarrhoea; constipation; nausea; weakness; insomnia; sexual dysfunction; damage to mucosa. None known for occupational exposure.
Women aged 75 years and over ; do not require referral for DEXA scan but bisphosphonate therapy is recommended Women aged 65 74 years ; require DEXA scan and if this result reveals a TTscore of -2.5 SD or below ; require consideration for bisphosphonate * therapy * bisphosphonate Women aged 65 years and under ; require referral for DEXA. If this reveals a T-score Tof below -3 SD or -2.5 SD plus an additional independent risk factor ; then addition of a bisphosphonate * drug is bisphosphonate * recommended.
To be difficult to treat with any modality, including radiotherapy and stereotactic radiosurgery. Hydroxyurea is a ribonucleotide reductase inhibitor commonly used in the treatment of hematologic malignancies.9 It diffuses into cells and inhibits DNA synthesis without interfering with RNA or protein synthesis by blocking the conversion of ribonucleotides to deoxyribonucleotides. Hydroxyurea was first reported to inhibit primary human meningioma cell growth in culture and in xenograft transplantation models.12 This drug was believed to be a powerful inhibitor of meningioma cell growth, most likely by causing apoptosis in the tumor cells. Recently, Rosenthal et al9 reported on 15 meningioma patients with residual tumor postresection and progressive growth, showing that 11 achieved stable disease with hydroxyurea. Mason et al13 treated 20 documented enlarging meningiomas 16 benign, 3 atypical, and 1 malignant ; with hydroxyurea. Twelve of the 16 benign tumors stabilized at a median duration of therapy of 122 weeks. The 4 remaining patients with benign tumors, as well as all of those who had atypical and malignant meningiomas, had progression of their disease. It appears that complete tumor regression is not a realistic goal with this drug. However, a reasonable number of patients have experienced tumor stabilization with minimal incidence of side effects after treatment with hydroxyurea. A current Southwestern Oncology Group protocol SWOG-S9811 ; is currently enrolling patients to further answer this question.
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It is difficult to maintain this strategy over time because the symptoms of OCD show up in behaviour. Children are very sensitive and intuitive. They notice when someone in the family has changed, or when tension surfaces. If the atmosphere in the family suggests that the subject should not be discussed, children will develop their own, often wrong, ideas. Young children often see the world as revolving around themselves. This is especially true of children age three to seven years. If something happens that upsets people in the family, they may think it is their fault. For example, if someone fears contamination and becomes upset after a child touches a "contaminated" object, the child may assume he or she is the cause of the ill person's extreme behaviour. To explain mental illness and OCD to children, it is important to tell them only as much as they are mature enough to understand. Toddlers and preschool children can understand simple, short sentences. These need to be worded in concrete language without much technical information. For example: "Sometimes daddy feels sick and it makes him upset." "When mommy is sick, touching the sink makes her upset." Elementary-school children can process more information. They are able to understand the concept of OCD as an illness, but may be overwhelmed by details about therapies and medications. OCD could be explained to children of this age group like this: "OCD is a kind of illness that makes people worry a lot about germs and getting sick. Worrying so much makes them do things over and over again." Teenagers are generally able to manage most information. They often need to talk about what they see and feel. They may ask about the genetics of this illness, or they may worry about the stigma of mental illness. Sharing information creates more dialogue. When speaking to children, it is helpful to cover three main areas.
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