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DEXAMETHASONE SODIUM PHOSPHATE Dexamethasone Sodium injection eq 4mg phosphate ml Phosphate injection eq 4mg phosphate ml injection eq 10mg phosphate ml injection eq 4mg phosphate ml injection eq 4mg phosphate ml injection eq 4, 10mg phosphate ml injection eq 4mg phosphate ml injection eq 10mg phosphate ml injection eq 20mg phosphate ml injection eq 4mg phosphate ml injection eq 4, 10, 20, phosphate ml injection eq 4, 10mg phosphate ml injection eq 24mg phosphate ml injection eq 4mg phosphate ml solution, ophthalmic-otic eq 0.1% phosphate solution, ophthalmic eq 0.1% phosphate solution, ophthalmic eq 0.1% phosphate Brand s ; Dexacen-4 Dfcadron Hexadrol Hexadrol Decadfon continued on the next page.
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ASTHMA Article #1 Author: Qureshi F et al Title: Comparative efficacy of oral Dexamethasone versus oral prednisone in acute pediatric asthma Journal: Journal of Pediatrics, 2001, 139: 20-26 Summary: 533 patients between two and 18 years of age were prospectively enrolled in this offeven day, randomized trial. Pts who required a second dose of albuterol were enrolled to receive either prednisone 2mg kg max 60mg ; or Deccadron of 0.6mg kg up to 16mg ; At discharge, pts who received prednisone received four additional daily doses, and those receiving Decadron received one additional single dose to take the next day. The primary outcome measure was relapse at 10 days. 7.4% of 272 pts receiving dexamethasone and 6.9% of 261 pts receiving prednisone relapsed statistically not a significant difference between groups ; . In the prednisone group, more children had vomiting, more pts missed two or more days of school, and more parents missed work The authors concluded that two doses of oral Decadron had similar efficacy to 5 doses 5 days ; of prednisone, with greater compliance, fewer side effects, and fewer missed school work days. Abstract from the 2nd Mediterranean Conference on Emergency Medicine, Sitges Spain 9 2003 Authors: Atlaminim S, Robertson , Jastaniah W, etal Title: Single dose oral dexamethasone in the emergency management of children with exacerbation of mild to moderate asthma. Institution: British Columbia's Children's Hospital, Canada Summary: This was a prospective, randomized double blind trial of 134 children 2-16 years of age who presented to the ED and required more than 1 albuterol treatment. Subjects were randomized to receive either a single dose of oral dexamethasone 0.6mg kg ; or five days of twice a day oral prednisolone 1mg kg dose ; . The primary outcome measures were the number of days needed for the Peak Expiratory Flow Rate to return to 80% of predicted value for height and or the number of days needed for the Patient Self Assessment scores to return to baseline. Other outcome measures included: admission rate, time to disposition from the ED, number of albuterol treatments in the ED, and improvement by day 5. Baseline characteristics were the same between both groups. The drop out rate for vomiting was higher in the prednisolone group. The time for the PEFR or the Patient Self Assessment score to return to baseline, the number of albuterol treatments required in the ED, and the overall admission rates were comparable between both groups. Authors conclude that a single dose of oral dexamethasone is a safe and efficacious alternative to 5 days of oral prednisolone in children with mild to moderate asthma exacerbations. Identification of medically relevant Trichosporon species based on sequences of internal transcribed spacer regions and construction of a database for Trichosporon identification. J Clin Microbiol 37, 19851993 and didanosine. In the latter case, subsequent drugs worked in only 11% of patients. The incidence of diabetes linked to obesity has escalated significantly in US. There are not many studies which have looked at the impact of weight loss in a controlled educative program on decrease of diabetes medication, and or HbA1c reduction. HbA1c in turn indicates the possible level of glycation damage to tissues, and thus of diabetic complications, it remains high for years. 34 patients with a mean BMI of 38.398.38 enrolled for the study. All patients were seen by an endocrinologist at Tulane Hospital and were offered participation in a weight management program at Tulane Center for Diabetes for a period of 16 weeks. A low-calorie diet 800 kcal, 75 g protein ; and a weekly educative session were used to reduce weight. They were divided into three groups for analysis according to the length of participation in the weight management program. HbA1c was significantly reduced in patients with successful weight loss. No significant reduction was seen in antidiabetic drugs. Hence, although diabetes is considered an important medical problem in US, promotion of lowcalorie diets, and strong emphasis on exercise for loss and maintainence of weight need to be considered as well. Cause any discomfort or irritation. Long Term Exposure: No data for health effects associated with long term inhalation.

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