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Treatment options for low-grade lymphoma. Gunnar Juliusson, Dept of Hematology, University Hospital, Linkoping, Sweden The group of indolent lymphomas contains several different entities, the most common being follicular lymphoma and chronic lymphocytic leukaemia. Mantle cell lymphoma is an entity important to recognize, since although response may follow initial therapy, refractory progression occurs early, and survival is poor. On the other hand, marginal zone lymphoma in the ventricle, which is associated with Helicobacter pylorii infection, is easily managed with anti-bacterial treatment alone. The major subgroups have had a similar outcome for decades, with treatment based on alkylating agents. Such treatment may well reduce symptoms and induce remissions, but has not showed to prolong survival. More intensive anthracyclin-containing combination therapy may prolong response duration. Interferon alpha has been studies extensively together with and following chemotherapy. As maintenance following intensive combination chemotherapy IFN leads to a prolongation of remission duration, and in one study also survival was improved. During the 1990's, purine analogues were introduced. Single agent therapy with fludarabine produce tumour responses, but was not clearly better than alkylator-based treatment. With the combination improved responses, including molecular responses were achieved, and randomized studies are evaluable soon. Rituximab, a humanized chimeric anti-CD20 antibody has a significant apoptosis-inducing activity in follicular lymphoma. Anti-CD20 antibodies have also been used as carriers for radioactive isotopes. High dose chemotherapy with or without total body irradiation and supported with autologous stem cells have been studied. It was shown that patients given autologous bone marrow treated in vitro with a cocktail of anti-B-cell antibodies and complement following high dose cyclophosphamide and total body irradiation had a significantly better outcome if the purging procedure resulted in a total depletion of tumor cells from the harvest in vitro before reinfusion. A randomized study comparing purged and unpurged stem cells with chemotherapy only was intended, but the inclusion rate was insufficient. Overall, it has not been clearly shown that autologous transplantation improves outcome for patients with follicular lymphoma, with the exception for patients who have had transformation to high-grade lymphoma. In this situation high-dose therapy.with autologous transplantation could be considered standard care. Allogeneic transplant may well turn out to be an option, since such transplants may be performed with reduced intensity conditioning suitable for elderly patients, and since graft-versus-lymphoma is active in eradicating lymphoma. However, there are still problems with controlling graft-versushost disease, as well as the long-lasting post-transplantation immune suppression and mescaline.
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Day AdEERS ; . The required report must be completed in AdEERS within 5 or 10 calendar days of the initial phone report, as directed by the Data Manager taking the call. SAEs reported using AdEERS also must be reported on the AE case report form see Section 12.1 ; . Any late death more than 30 days after last treatment ; attributed to the protocol treatment possible, probable or definite ; should be reported to RTOG via the AE SAE telephone line within 24 hours of discovery. An expedited report, if applicable, will be required within 5 or 10 calendar days. All supporting source documentation, if applicable or if being faxed to NCI, must be properly labeled with the study case numbers and the date of the adverse event and must be faxed to the RTOG dedicated SAE FAX, 215-717-0990, before the five or ten-calendar-day deadline to allow RTOG to comply with the reporting requirements of the pharmaceutical company companies supporting the RTOG trial. All forms and supporting source documentation ; submitted to RTOG Headquarters must include the RTOG study case numbers; non-RTOG intergroup study and case numbers must be included, when applicable. Submitted AdEERS Reports are forwarded to RTOG electronically via the AdEERS system. Use the patient's case number as the patient ID when reporting via AdEERS. SAE reporting is safety related and separate and in addition to the Data Management reporting requirements as outlined in the previous AE reporting section. Any event that meets the above outlined criteria for an SAE but is assessed by the AdEERS System as "expedited reporting NOT required" must still be reported for safety reasons and to fulfill the obligations of RTOG to the pharmaceutical company companies supporting the RTOG trial. Sites must bypass the "NOT Required" assessment and complete and submit the report. The AdEERS System allows submission of all reports regardless of the results of the assessment. Note: Sites must print the AdEERS report and fax it to the FDA, FAX 1-800-332-0178. Acute myeloid leukemia AML ; or myelodysplastic syndrome MDS ; AML or MDS that is diagnosed during or subsequent to treatment in patients on NCI CTEP-sponsored clinical trials must be reported using the NCI CTEP Secondary AML MDS Report Form available at : ctep ncer.gov forms index . The report must include the time from original diagnosis to development of AML MDS, characterization such as FAB subtype, cytogenetics, etc., and protocol identification RTOG study case numbers ; . This form will take the place of a report via the AdEERS system and must be faxed to the Investigational Drug Branch, FAX 301-230-0159, and mailed to RTOG Headquarters address below ; within 30 days of AML MDS diagnosis. RTOG Headquarters AML MDS Report 1818 Market Street, Suite 1600 Philadelphia, PA 19103 and methamphetamine.
Other Directors Rick Augsburger, Church World Service and Witness Bob Ellis, M.P.H., Presbyterian Church USA ; , International Health Ministries Office Worldwide Ministries Division Ray Martin, M.P.H., Christian Connections for International Health, Director-at-Large Caroline Njuki, Ph.D., United Methodist Church General Board of Global Ministries Mario Ochoa, Adventist Development and Relief Agency International Donald Parker, M.D., Director-at-Large Paul Pereverzoff, Mennonite Central Committee Mark Spina, Episcopal Relief and Development I.M.A. STAFF NEW WINDSOR OFFICE Paul Derstine, President Daniel Aukerman, M.D., M.P.H., Vice-President for International Program Development and Coordination Dana McDonald, Vice-President for Finance and Administration Connie Bowman, Administrative Services Assistant Glen Brubaker, M.D., M.P.H., Medical Advisor Kathleen Campanella, Coordinator of Public Information Part-time ; Sarla Chand, Faith-Based Organization Coordinator; ACCESS Project effective April 2005 ; Charles Franzn, International Grants Manager effective August 2005 ; Judy Gilbert, Financial Services Manager Tony Harden, Administrative Assistant for Program Resources effective November 2004 ; Carol Hulver, Assistant Vice-President for Administration through March 2005 ; Assistant Vice-President for Human Resources effective December 2004 ; Darlene Hylton, Medical Inventory Services Assistant 7, for example, naproxen.
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