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2005 145, 535 % chg 7.7 -14.6 -6.8 -0.8 9.7 51.7 10.5 -5.1 8.9 -30.7 15.9 40.6 -13.3 -1.7 -30.0 13.3 -20.3 -14.6 -8.1 -43.0 3.8 84.7 -49.0 1.6 59.6 -90.8 -36.7 -15.0 39.2 Johnson & Johnson acquire Rembrandt oral care products in December 2005 from Procter & Gamble Co. shortly after P&G purchased Gillette, Rembrandt's former parent. Personnel, brands, agencies Corporate: William C. Weldon, chmn & CEO; Brian Perkins, VP-corporate affairs; Kimberly Kadlec, chief media officer & VP, ww; Joseph D. McCarthy, VP-ww adv. McCann Erickson Worldwide, New York. Carol Smith, exec VP & ww acct dir. -- Johnson & Johnson. OMD Worldwide, New York. Elyse Hoelzer, global acct dir; Ronnie Beason, client comms dir; Ildi Pap, print dir. -- media buying, Johnson & Johnson. DraftFCB, New York. Jennifer Gavin, VP & acct dir. R GA, New York. Richard Marks, grp acct dir. -- interactive mktg, Johnson & Johnson. AtmosphereBBDO, New York. Andreas Combuechen, CEO & chief creative officer; Stephanie Foggle, acct dir. -- interactive mktg, Johnson & Johnson. Alza: 1900 Charleston Rd, Mountain View, Calif. 94039 Phone: 650 ; 564-5000. Alejandro Zaffaroni, founder. No agency. Centocor: 800 Ridgeview Dr., Horsham, Pa. 19044 Phone: 215325-6834. Linda Brueckman, mgr-corp comms. BrandPharm A Publicis Healthcare Communications Group Company ; , New York. Kelly Hughes, grp acct dir. -- Remicade arthritis Rx. ID Media, New York. Jeff Hinz, sr VP & dir-client svcs. -- media svcs. OgilvyOne Worldwide, New York. Donna Tuths, sr ptnr & direct mktg & client svcs dir-healthcare. -- direct mktg. DePuy: 700 Orthopaedic Dr., Warsaw, Ind. 46581-0988 Phone: 574 ; 267-8143. Dick Rogers, pres; Thomas Sullivan, pres-DePuy Orthopaedics, U.S.; Eric Dremel, VP-sls. DDB Worldwide Communications Group, New York. ID Media, New York. Jeff Hinz, sr VP & dir-client svcs. -- media svcs. J&J Merck Consumer Pharmaceuticals Co.: 7050 Camp Hill Rd., Ft. Washington, Pa. 19034-2292 Phone: 215 ; 273-7700. Renaat Van den Hooff, ww pres. Alchemy, New York. Amy Saks, CEO & chief creative officer. -- Mylanta, Mylicon, Mevacor, Pepcid. Conill, New York. Carla Poumian-Ruiz, acct dir. -- Hispanic adv, Mylanta, Pepcid. Janssen Pharmaceutica Products: 1125 Trenton-Harbourton Rd., Titusville, N.J. 08560-0200 Phone: 609 ; 730-2000. Janet N. Vergis, pres; Jeff Smith, pres-Janssen Ortho-McNeil Primary Care. KPR, Titusville, N.J. Marc Porter, sr VP & mgmt super. -- Janssen Ortho-McNeil Primary Care, Paliperidone, Riperdal Consta, . McCann Healthcare Worldwide, Ewing, N.J. Charlie Buckwell, chief exec-Regan Campbell Ward McCann. -- Pipeline Products.
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Are taking any other medications, including prescription, nonprescription and natural health products as drug interactions are possible, in particular corticosteroids, cyclosporine NEORAL * ; , fibrates e.g. gemfibrozil [LOPID] ; , oral anticoagulants eg. warfarin [COUMADIN] ; , phenytoin, oral hypoglycemics, non steroidal anti-inflammatory drugs, erythromycin, lipid lowering doses of niacin nicotinic acid ; , nefazodone SERZONE ; and colchicines have a personal or family history of muscular disorders had any past muscle problems pain, tenderness ; , after using an HMG-CoA reductase inhibitor "statin" ; such as atorvastatin LIPITOR ; , fluvastatin LESCOL * LESCOL * XL ; , lovastatin MEVACOR ; , pravastatin PRAVACOL ; , rosuvastatin CRESTOR ; or simvastatin ZOCOR ; or have developed an allergy or intolerance to any of them have kidney disease. have liver problems: liver function tests will normally be done before starting LESCOL * LESCOL * XL, at dose increase and at various intervals during treatment to check for undesirable effects. have diabetes have undergone surgery or other tissue injury do excessive physical exercise have low blood pressure have congestive heart failure suffer from seizures If you are older than 70 years your doctor may want to clarify whether you have risk factors for muscular diseases. This may require specific blood tests. The safety of LESCOL * LESCOL * XL in adolescents and children has not been established.
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Background. Aptivus tipranavir ; received approval from the US Food and Drug Administration FDA ; in June 2005. The drug is manufactured by Boehringer Ingelheim. Aptivus is a protease inhibitor and must be used in combination with Norvir ritonavir ; and at least two other anti-HIV drugs. Aptivus is only approved for HIV-positive people who have failed other anti-HIV drug regimens including those containing protease inhibitors ; . Dose. Aptivus is supplied in soft gelatin capsules of 250mg. The recommended dose of Aptivus is 500mg two 250-mg capsules ; with 200 mg two 100-mg capsules ; of Norvir twice daily. So, a total of 1000 mg of Aptivus and 400 mg of Norvir is taken each day. Food restrictions. Aptivus should be taken with food, preferably a complete meal. Storage. Unopened bottles of Aptivus capsules should be stored in a refrigerator 36-46F ; . Once the bottle is opened, the contents must be used within 60 days. Aptivus can be brought along while traveling if the bottle remains at a temperature of approximately 59F to 86F. Patient assistance. Patient should call 800.274.8651. Side effects and toxicity. The most common side effects include diarrhea, nausea, vomiting, stomach pain, tiredness, fever, bronchitis, depression, and headache. Women taking birth control pills or hormone replacement therapy may be more likely to get a skin rash. Serious side effects include liver problems, including liver failure and death. You should stop taking Aptivus ritonavir treatment and call your doctor immediately if you experience tiredness, general ill feeling or "flu-like" symptoms, loss of appetite, nausea, yellowing of your skin or whites of your eyes, dark colored urine, pale stools bowel movements ; , or pain, ache, or sensitivity on your right side below your ribs. Other serious side effects include rash, increased bleeding in patients with hemophilia, diabetes and high blood sugar hyperglycemia ; , worsening of pre-existing diabetes, increased blood fat lipid ; levels, and changes in body fat lipodystrophy ; . Last updated November 2005. When taking Aptivus, caution should be exercised in patients with hemophilia, diabetes, or liver problems, as well as those who are infected with hepatitis B or hepatitis C, who are allergic to sulfa medicines, who are pregnant or plan on becoming pregnant, who are breastfeeding, or who are using estrogens for birth control or hormone replacement. There are no adequate and well-controlled studies of Aptivus in pregnant women for the treatment of HIV infection. Aptivus should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drug interactions. Aptivus should not be taken with the following: Halcion triazolam ; , Versed midazolam ; , Hismanal astemizole ; , Seldane terfenadine ; , Orap pimozide ; , Propulsid cisapride ; , Pacenone amiodarone ; , Vascor bepridil ; , Tambocor flecainide ; , Rythmol propafenone ; , Quinaglute Quinidex quinidine ; , Rifadin or Rimactane rifampin ; , Antabuse disulfiram ; , Flagyl metronidazole ; , St. John's wort Hypericum perforatum ; , cholesterol-lowering drugs such as Mevqcor lovastatin ; and Zocor simvastatin ; , and ergot alkaloids derivatives medications to treat migraine headaches, for example Ergostat, Cafergot, etc. ; . Because Aptivus lowers the levels of birth control pills, an additional or alternative method of birth control should be used. Also, the following medications may require a dosing change of Aptivus and or the other medicine, and should be used with caution: HIV medications such as Ziagen, Videx EC ; , Retrovir included in Combivir and Trizivir ; , Lexiva or Agenerase ; , Kaletra, and Fortovase or Invirase; Coumadin warfarin antifungals; antimycobacterials such as clarithromycin or rifabutin; calcium-channel blockers, with the exception of Vascor bepridil ; , which cannot be used with Aptivus Norvir at all; medications to treat diabetes such as Amaryl glimepiride ; , Metaglip glipizide ; , Glucovance glyburide ; , Actos pioglitazone ; , Prandin repaglinide ; , and Orinase tolbutamide Lipitor atorvastatin medicines to prevent organ transplant rejection; methadone; Demerol meperidine oral contraceptives; and antidepressants such as Prozac fluoxetine ; , Paxil paroxetine ; , Zoloft sertraline ; , and Norpramin desipramine ; . Levels of Viagra sildenafil ; , Cialis tadalafil ; , and Levitra vardenafil ; may be significantly raised in the presence of Aptivus and dose reductions are recommended.
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DESCRIPTION MEVACOR * Lovastatin ; is a cholesterol lowering agent isolated from a strain of Aspergillus terreus. After oral ingestion, lovastatin, which is an inactive lactone, is hydrolyzed to the corresponding hydroxyacid form. This is a principal metabolite and an inhibitor of A HMG-CoA ; reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate limiting step in the biosynthesis of cholesterol. Lovastatin is [1S-[1 R * ; , 3, 7, 8 * , 4S * ; , 8a]]-1, 2, 3, ; ethyl]-1-naphthalenyl 2-methylbutanoate. The empirical formula of lovastatin is C24H36O5 and its molecular weight is 404.55. Its structural formula is.
Her crash. When even watching TV tired her out, she lost her friends because she didn't have any energy for them, and they didn't know what to do with her. After years of not knowing what she had or what to do about it, and getting gradually worse, Chris was diagnosed with CFS. She turned to alternative medicine and changed her diet. Allergy tests convinced her to give up wheat, dairy and sugar. Sugar was a hard habit to break, and she would slip back to eating it. The resulting numbness and tingling In her hands and feet convinced her to break with sugar for good. Her new diet helped her regain some energy. Gradually, she built up to 3 hours of activity a day, and her brain fog lifted a bit so she could focus. Because of the great delay in getting diagnosed with CFS, it has taken Chris years to get where she is today. Last year, Chris began a weight-lifting class for older women. She increased very gradually and is now at the top weight she wants to lift, as more would be too draining. She lifts weights three times a week, and walks 40 minutes several times a week. Her strength has improved markedly in a year. She has to rest for some hours after a workout, but insists the athletics give her added vitality. A class on partner yoga gave her an opportunity to do something active with her partner. The instructor told them the class would deepen their relationship. Chris and her partner were pleased and surprised to find it was true. She also noticed a great improvement in flexibility and a lack of creakiness. Chris's advice to other CFS FM people is to face the reality of reduced energy and use what energy they do have to do something they love. Chris has become something and rizatriptan, because mevacor muscle.
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THERAPEUTIC DRUG CLASS PREFERRED BRAND NAME AGENTS LIPOTROPICS, STATINS CRESTOR rosuvastatin ; LESCOL fluvastatin ; LESCOL XL fluvastatin ; simvastatin PA NOT Required GENERIC AGENTS STATINS ALTOPREV lovastatin ; LIPITOR atorvastatin ; lovastatin MEVACOR lovastatin ; pravastatin PRAVACHOL pravastatin ; ZOCOR simvastatin ; STATIN COMBINATIONS ADVICOR lovastatin niacin ; VYTORIN simvastatin ezetimibe ; MACROLIDES KETOLIDES Oral ; KETOLIDES KETEK telithromycin ; MACROLIDES BIAXIN XL clarithromycin ; Z-MAX azithromycin ; azithromycin erythromycin BIAXIN clarithromycin ; clarithromycin E.E.S. erythromycin ; ERYC erythromycin ; ERYPED erythromycin ; ERY-TAB erythromycin ; ERYTHROCIN erythromycin ; PCE erythromycin ; ZITHROMAX azithromycin ; CADUET atorvastatin amlodipine ; PA IS Required NON-PREFERRED AGENTS PA CRITERIA.
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The generous gift of cyclin D1 and cyclin E cDNA probes and antibodies from Dr. Liz Musgrove Garvan Institute, Sidney, Australia ; , of human cyclin D1-luciferase reporter genes from Prof. M. Beato IMT, Marburg, Germany ; , of human ER mutant expression vector from Prof. P. Chambon IGBMC, Strasbourg, France ; and of ERE-containing promoter constructs from Prof. D. McDonnell Department of Pharmacology and Cancer Biology, Duke University Medical Center ; are gratefully acknowledged. This work was supported by grants from MIUR PRIN 2001-02 ; and 2001 Universit "Roma Tre" to M.M., from MIUR PRIN 2001-02 ; to F.B and from Associazione Italiana per la Ricerca sul Cancro to A.W and mellaril.
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Class: HIV protease inhibitor PI ; Standard dose: ree 200 mg hard-gel capsules three times a day with food, or within two hours aer a meal. However, should be dosed in combination with Norvir. Invirase 1600 mg + Norvir 100 mg once daily or Invirase 1000 mg + Norvir 100 mg twice-aday. Take a missed dose as soon as possible, but do not double up on your dose. Manufacturer contact: Roche Pharmaceuticals, rocheusa , 1 800 ; 9104687 AIDS Treatment Information Service: 1 800 ; HIV0440 4480440 ; Potential side effects and toxicity: Most common are stomach related: diarrhea, abdominal discomfort and nausea. Because there is low absorption 4 to 6% ; of the drug into the body, there are few other side effects. As seen with all other protease inhibitors are increased levels of cholesterol and triglycerides, except possibly unboosted Reyataz atazanavir ; and these increased levels may be associated with heart disease. Other possible side effects are lipodystrophy body fat changes, including thinning of the face, arms and legs, with or without fat accumulation in the stomach, breasts and sometimes the upper back ; , worsening or new cases of diabetes symptoms include increased thirst and hunger, frequent urination, unexplained weight loss, fatigue, and dry itchy skin; see your doctor promptly ; and increased bleeding in hemophiliacs. Potential drug interactions: Do not take with Tambocor ecainide ; , Rythmol propafenone ; , Versed, Halcion, Hismanol, Seldane, rifampin, ergot derivatives such as Cafergot, Wigraine and Methergine, D.H.E. 45, in any form--serious interactions seen with dilation during gynecological exams ; , garlic supplements, or the herb St. John's wort. Do not use Zocor simvastatin ; or Mevacorr lovastatin lipid-lowering alternatives are Lipitor atorvastain ; , Lescol, and Pravachol parvastatin ; , but they should be used with caution due to potential for liver toxicity. Viramune, Sustiva and Mycobutin rifabutin ; decreases Invirase levels. Invirase may increase dapsone levels. Antifungal Nizoral ketoconazole ; or Sporonox itraconazole ; , used for treatment of candidiasis thrush ; , increases the amount of Invirase in the body. Do not take with birth control pills; Invirase reduces level of ethinyl estradiol by 40%. Prescriber may need to adjust doses accordingly. Rescriptor, Crixivan, Norvir and Viracept all signicantly increase Invirase's concentrations. Protease inhibitors increase blood levels of Viagra sidenal citrate ; , so initially the Viagra dose should be 12.5 mg 1 4 of 50 mg tablet ; and increased as needed and tolerated. It's recommended that people on PIs do not exceed 25 mg of Viagra in a 48-hour period because of potential for serious reaction. Tips: Invirase has made a comeback, due to study results indicating strong efficacy with fewer side effects when taken with a mini-dose of Norvir, as compared to Fortovase Norvir. is older version of saquinavir hard-gel capsules is rarely used except in combination with Norvir low-dose ; to minimize gastrointestinal adverse events. Must be taken with food. ere is also some research supporting Invirase 1000 mg + Kaletra standard dose twice-a-day.
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Mucosa in bronchial asthma-suppression of cytokine mRNA. Arerugi 1998; 47 6 ; : 604-13 in Japanese ; . Cogan E, Schandene L, Crusiaux A, Cochaux P, Velu T, Goldman M. Clonal proliferation of type 2 helper T cells in a man with the hypereosinophilic syndrome. N Engl J Med 1994; 1330: 535-8. Takamizawa T, Iwata T, Watanabe K et al. Elevated production of interleukin-4 and interleukin-5 by T cells in a child with idiopathic hypereosinophilic syndrome. J Allergy Clin Immunol 1994; 93: 10768. Konno S, Asano K, Okamoto K, Adachi M. Inhibition of cytokine production from human peripheral blood leukocytes by anti-allergic agents in vitro. Eur J Pharmacol 1994; 264 3 ; : 265-8. Masuyama K, Ishikawa T, Ohyama M et al. The long-term administration of Azelastine for allergic rhinitis. Jibikatenbou 1992; 35: 95-106 in Japanese ; . Watanabe N. Suppressive effect of Terfenadine on eosinophilia and anaphylactic reaction. Prog Med 1998; 18: 1961-5 in Japanese ; . Simon HU, Plotz SG, Dummer R, Blaser K. Abnormal clones of T cell producing interleukin-5 in idiopathic eosinophilia. N Engl J Med 1999; : 1112-20 and micardis.
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In some cases, if there is still tumor on the scan after the "standard" radiation, an additional dose of a very focused form of radiation, called stereotactic radiosurgery, may be tried. If these treatments do not work, or they may be considered instead of the standard therapy ; , then other therapies are considered. There are 2 general classes of treatment: "FDA Approved" or "Experimental". "FDA approved" treatments have been deemed "safe and effective" for at least 1 disease. Not necessarily for brain tumors. If they were not approved for brain tumors, your doctor may still prescribe it for your brain tumor. This is called "Off Label Use". Many drugs used commonly for brain tumors are used off label. Although legal, and easily available, you sometimes have trouble getting your insurance company to pay for off label usage because they argue it is experimental. In such cases, know that you can fight the insurance company's denial. You should enlist your neuro-oncologist to help get it approved by your insurance company. "Experimental" The treatment has not been approved yet, and may be hard to obtain. A clinical trial defied below ; is the best way of trying experimental therapies as the doctors will watch you very carefully for signs of side effects. Be aware that there is a mechanism for using an experimental drug outside of clinical trials only for those who do not qualify for the usually rigid entrance criteria of clinical trials. This is called "Compassionate Usage.
The doctors have advised her of another medicine, can't recall the name and told her about boniva, but i stil wont to check about side effect known to people who have already taken this treatment besides those effects listed on their official sites and minipress and mevacor, for example, neurontin.
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On discretionary review, the Supreme Court stated three conclusions. First, the appeals court erred in assuming the basis of the finding of negligence at trial. The Court of Appeals was not in a position to make that finding without a clear showing in the record. Second, the court held that proximate cause does not require the defendant to present medical expert testimony in all cases of contributory negligence. Finally, the court held that there was sufficient evidence for a jury to find a causal connection between missed appointments and the spread or increased rate of spread of cancer. Cobo v. Raba, 347 N.C. 541, 495 S.E.2d 362 1998 ; dealt with a claim by a psychiatric patient against his psychiatrist. The patient, Cobo, had a history of psychiatric problems for which medication had not been, to him, satisfactory. Dr. Cobo also had engaged in high-risk behavior including drug abuse, alcohol abuse and unprotected homosexual sex with paid prostitutes. Defendant had discussed all of this with Cobo, who acknowledged the risky nature of his life style. Nevertheless, he continued these activities and, in addition, he ignored defendant's recommendation that he seek medical attention for HIV. In the suit, Cobo alleged that defendant had negligently failed to prescribe medication and continued him in psychotherapy which was ineffective. It is important to note that plaintiff was, himself, a psychiatrist and, independently of anything defendant said or did was well aware of the risks inherent in his behavior. The court noted that in McGill it had held that plaintiff's passive conduct in failing to keep appointments was sufficient to constitute contributory negligence and in Cobo the plaintiff's negligence was active and sufficient to support a jury verdict of contributory negligence. Finally, in Andrews v. Carr, 135 N.C. App. 463, 521 S.E.2d 269 1999 ; , the court again dealt with the defense of contributory negligence. Here, defendant Carr performed hernia surgery on plaintiff. During the surgery, defendant lost his anatomical point of reference, confusing the penis for the spermatic cord and dissected along the shaft of the penis, cutting it. Then, instead of pulling the spermatic cord away for placement of a drain, he pulled the penis away, pulling the penile structure out of the dissected skin. Realizing the error, Carr replaced the penis and closed the wound. Following the surgery, Carr told plaintiff he had injured the penis, but did not tell him that the cut was from the.
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Abstracts were scanned by two reviewers RT and HB ; and potentially eligible studies were retrieved in hard copy. Assessment of each study against the inclusion criteria and extraction of data was done independently by two of three reviewers RT, HB, SDC ; using the forms in appendix 1 and 2. In addition, two panellists contributed to the selection of studies and data extraction for papers in languages other than English or French Uwe Gross, Francis Deroin ; . Quality of the studies was assessed by a quality assessment form, which was especially built for this work Appendix 3 ; . We recorded the following characteristics of the study quality: i ; design of the study randomization, masked evaluation ; , ii ; selection procedures inclusion, exclusion ; , conduct of the study withdrawal, outcome measurement ; , analysis adjustment for confounding factors ; . In addition, an overall assessment was noted 0 for unacceptable, 1 for weak but acceptable, 2 for good and 3 for very good quality. This notation was performed by the reviewer helped by the specific items checked in the quality assessment form. The final quality score was the result of a personal reviewer evaluation and not a combination of item results. For each study, the evaluation was performed by two reviewers and a third one if necessary, because drug interactions.
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