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Unprecedented efficacy in the treatment of CML Driving pre-launch awareness Sales performance to date Conclusions: influencers of Gleevec's early success in an immature market Nexium: switching strategy targets physicians and patients Nexium's launch strategy Sales performance to date Conclusions: how did AstraZeneca switch patients and physicians from Losec to Nexium? Cymbalta: targeting the symptoms of depression to fulfil unmet needs in a competitive market Lilly's pre-launch strategy Future sales potential Xigris: suboptimal launch strategy undermines sales growth in potentially lucrative market Sepsis: a large and open market Sales performance to date So what went wrong? Fighting back post-launch Conclusions Best practice recommendations: adjusting to existing market dynamics.

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