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Hypersensitivity reactions to paclitaxel have been reported to occur in approximately 10% of patients; however, less than 1% of patients experience severe hypersensitivity reactions 1 ; . We report only the second published case of a generalized seizure occurring in the context of a paclitaxel reaction. In 1989, McGuire et al. 2 ; described a patient who developed a grand mal seizure 2 hours after the commencement of the first infusion of paclitaxel. The infusion was subsequently recommenced, resulting in prolonged seizures. The adverse effect was presumed to be caused by paclitaxel in view of the temporal relationship. We now describe a 57-year-old woman who was diagnosed with a primary peritoneal cancer. She underwent debulking surgery, with the histology confirming serous papillary carcinoma. Her postoperative recovery was unremarkable apart from a mild wound infection requiring oral antibiotic therapy. The only clinically significant problem in her medical history was mild asthma. On the tenth postoperative day, she commenced chemotherapy with carboplatin and paclitaxel. She was given 20 mg of dexamethasone 12 hours and 6 hours before receiving the paclitaxel. She also received 10 mg of dexamethasone, 50 mg of ranitidine, 12.5 mg of phenergan, and 5 mg of tropisetron before receiving the paclitaxel infusion. She was to receive paclitaxel at a dose of 175 mg m2 268 mg total dose based on a body surface area of 1.53 m2 ; . Five minutes after the start of the paclitaxel infusion, the patient reported chest tightness and flushing, followed shortly by a generalized tonic clonic seizure. The patient's blood pressure dropped from the baseline level of 140 70 to 80 mmHg. The seizure was associated with urinary incontinence and tongue biting. The paclitaxel infusion was stopped immediately, and the patient was given oxygen. The seizure. Statins are the drugs that are known to lower bad cholesterol levels, because phenergan elixir.
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PHENERGAN ; Pharmacology and Actions Promethazine is a phenothiazine and acts as an antiemetic. Indications Promethazine is indicated for the prophylaxis and treatment of nausea and vomiting. Contraindications and Precautions Contraindicated in patients with central nervous system depression. Administration and Dosage 1. Adults: 12.5-25mg slow IV, or 25-50mg IM. Rapid IV administration may cause hypotension. Initial doses of 6.25 mg should be used in the elderly. Children: 6.25-12.5mg slow IV, or 12.5-25mg IM.
Some cases yes but it won't always protect you. It can slip and break." Then Barber adds, "If you're having sex using a condom is better than not." In and of itself those statements are at odds with each other and can confuse students and lead them to believe that since a condom "can't always protect them from HIV and STDs, " why bother. But SEICUS notes that those statistics on condom slippage and breakage are from a study published in Family Planning Perspectives that was conducted to determine failure rates for condoms. The study, says SIECUS, "actually found that 7 out of 405 condoms, or 1.7 percent, broke. This study did, however, report that 7.9% of the condoms EITHER broke or slipped off and that of the remaining condoms, 7.2% slipped off during withdrawal. The investigators attribute the slippage during withdrawal to user failure. In addition, they state that some participants reported that the condom did not remain on the penis during intercourse because it was deliberately removed, and they acknowledge that poorly worded questions could have allowed the participants to answer that the condom did not stay on without indicating that it was intentionally removed." It is crucial that we are completely honest with our children. We should be honest and accurate about the difference between the product failure rate of a condom and the user failure rate so they come to understand that condom users are in control of the condom's effectiveness a minimum of 98% of the time. SEICUS says, "If students were trained to negotiate condom use and to use condoms properly every time they have intercourse, these problems could be significantly reduced." SIECUS also expressed great concern because the curriculum is fear-based, uses shame and scare tactics "to promote" says SIECUS, "the message that abstinence until marriage is the only acceptable choice for adolescents." Information about contraceptives is for the most part omitted or portrayed as difficult to use or ineffective. SIECUS is also concerned because the 75 slides contain "erroneous statistics, exaggerated and erroneous medical information. information in the text is often not footnoted, making verification of sources difficult." SIECUS says that studies that are cited, "are often misquoted and medical misinformation about STDs and HIV AIDS is prevalent." SIECUS is concerned too because while the name of the organization suggests it carries out original research, "the Institute's publications are based largely on anecdotal data gathered by Dr. McIlhaney." The 75 slides include 40 discussing STDs including HIV AIDS that portray severe advanced cases of these diseases designed, says SIECUS, to scare teens instead of "helping them to recognize the signs of these diseases." I did witness several of these types of slides. SEICUS notes McIlhaney's curriculum also says that pre-marital sexual activity WILL result in certain negative outcomes, including damaged family relationships, lower self-esteem and poor emotional health, inability to be normal or healthy, and infertility as an inevitable result of STDs. SEICUS also found that McIlhaney's curriculum attempts to convince teens that they are more susceptible to STDs than adults, stating, "The cervix of a teenage girl has a lining called ectropian.that nourishes STD germs; as women reach their 20's or have a baby, the ectropian is replaced by the tougher lining of the vagina." text accompanying slide 41 ; . In fact, in Mr. Smith's class at Lesher Junior High on May 9, as Andrea Barber of the Alpha Center presented McIlhaney's STD slides, she said that, "teens are at a higher risk for STDs differences in immunity. A girl's cervix is more susceptible to an STD than older women in their 20's and 30's because it is moist, glossy, and tender." That does not even sound reasonable. SIECUS notes that such statements reveal several misunderstandings about female anatomy and inaccurately suggests that all teenage girls have a cervix with an ectropian lining. While some teenage girls do, SIECUS says, it is a normal condition that is found in pregnant women; women who have been exposed to DES in utero; women who take birth control pills; and very young women who have never been pregnant. An extropian lining occurs when cells from the canal of the cervix spread to the and premarin. The skin penetrative properties of the solvent-free nanoemulsion delivery technology and its low irritancy make this novel topical nanovehicle a promising candidate for effective transcutaneous delivery of lipophilic drugs, for example, phenerga suppositories.

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