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According to the The World Health Organization WHO ; , preterm labor PTL ; is defined as labor starting before 37 complete weeks of gestation and with intact fetal membranes WHO 1977 ; . Preterm delivery PTD ; or preterm birth is defined as the birth of a baby before 37 completed weeks of gestation. Rupture of the fetal membranes before the onset of labor is called premature rupture of the fetal membranes PROM ; . Using the word preterm less than 37 weekgestation ; PPROM ; or term more than 37 weeksgestation ; before PROM indicates the presence or absence of fetal maturity at the time of the complication Romero et al. 1999 ; . Traditionally, pediatricians have defined prematurity as a birth weight of 2, 500 g or less; and it is also commonly known as low birth weight LBW ; Schlesinger and Allaway 1955 ; . This list of definitions has been further expanded with the term "very preterm birth" Keirse 1989 ; , or "very low birth weight" VLBW ; which means the birth of a baby before 32 weeks of gestation or at a weight of 1, 500 g or less. "Extremely low birth weight" ELBW ; or "very, very low birth weight" 1, 000 g or less ; also are terms used, and in the literature has also been used the term "incredibly low birth weight" 750 g or less ; Amon 1999 ; . Not all preterm babies are born spontaneously; often labor must be induced before 37 weeks due to maternal or fetomaternal indications: this is defined as "iatrogenic prematurity." Of all women giving birth preterm, 30% to 40% experience PROM, 28% to 64% PTL, and 20% to 29% iatrogenic PTD Meis et al. 1987, Savitz et al. 1991, Romero et al 1999 ; . Furthermore, cervical insufficiency may be associated with 8% to 15% of all preterm births Parisi 1988 ; . Preterm birth is.
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Table 1 Demographic characteristics of study population Characteristic Test Control 23 13 10 value NS .05 NS NS .05. MUCINEX DM MYLERAN N NEXIUM NORVASC NOVOFINE 30 MIS DISP. DIAB. SYRINGE NOVOFINE 31 MIS DISP. DIAB. SYRINGE NOVOLIN 70 30 NOVOLIN N NOVOLIN R NOVOLOG NOVOLOG MIX 70 30 O OMNICEF ONE TOUCH ONE TOUCH ULTRA P PANCREASE PARNATE PAXIL PAXIL CR PLENDIL PRAMOSONE PRANDIN PRECISION XTRA TEST KIT & STRIPS PREMARIN TAB PREMPHASE PREMPRO PRESTIGE SMART TEST KIT & STRIPS PREVACID PREVACID NAPROXEN KIT PREVPAC PRILOSEC PROSCAR PROTONIX PULMICORT PURINETHOL Q QUIXIN R RELAFEN RELENZA RELPAX REMINYL RENOVA REQUIP RESCULA RETIN-A RETIN-A MICROGEL RETROVIR RHINOCORT RISPERDAL RISPERDAL-M RITALIN RITALIN LA RYTHMOL RYTHMOL SR S SENSIPAR SEREVENT SINGULAIR SPECTAZOLE STALEVO STARLIX SURESTEP T TAGAMET TARKA TAZORAC TEGRETOL XR THIOGUANINE THORAZINE TOPAMAX TOPROL XL TRICOR TRILEPTAL TRIZIVIR TRUETRACK TEST KIT & STRIPS TRUSOPT U ULTRACET ULTRAM VAGIFEM V VALTREX VENTOLIN HFA VESICARE VIAGRA VIRACEPT VIVELLE VIVELLE-DOT VOLTAREN W WELLBUTRIN SR WELLBUTRIN XL X XALATAN XOPENEX NEB Z ZADITOR ZANTAC ZELNORM ZIAGEN ZITHROMAX ZOCOR ZOFRAN ZOFRAN ODT ZOLOFT ZOVIRAX ZYBAN ZYMAR ZYRTEC ZYRTEC-D and proscar.
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Claims were invalid. In so ruling, the Federal Circuit answered in the negative the question: "for purposes of 112, 6, is sufficient corresponding structure disclosed when the specification simply recites that a claimed function can be performed by known methods or using known equipment where prior art of record and the testimony of experts suggest that known methods and equipment exist?" The court instructed that under 112, 6, "the applicant must indicate in the specification what structure constitutes the means." "[A] bare statement that known techniques or methods can be used does not disclose structure[, ]" and therefore does not meet the statutory requirements. Instead, "[t]he inquiry is whether one of skill in the art would understand the specification itself to disclose a structure, not simply whether that person would be capable of implementing a structure." Biomedino, LLC v. Waters Technologies Corp., No. 2006-1350, 2007 WL 1732121, * 1- * 6 Fed. Cir. June 18, 2007 ; . Claim Construction In a claim directed to a medical device requiring a "pneumatic cylinder, " the Federal Circuit held that the district court erred in narrowly construing the claim to further require that the cylinder have a pressure activated seal. The district court narrowly construed the claim since the written description only described embodiments of the invention with a pressure activated seal. The Federal Circuit held that under the particular circumstances this was error. Instructing that "[a] patent that describes only a single embodiment is not necessarily limited to that embodiment, " the court noted that the specification, while only describing cylinders with a pressure activated seal, did not describe the presence of the pressure activated seal as being "essential" to the operation of the invention. Accordingly, the specification did not provide a restrictive description that dictated a narrow claim construction. Further, the prosecution history showed that while all the claims from the parent application included the pressure activated seal as an express claim limitation, the inventor had omitted that limitation from the asserted claims issuing from a continuation application while retaining the limitation in other claims of the continuation application. According to the court, this provided strong evidence that the inventor intended to broadly claim the device as not requiring the pressure activated seal in the asserted claims. Further, the inventor had also submitted a petition to make special and in that petition accused products that did not have a pressure activated seal as, for example, side affects. 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Figure 6. Proarrhythmic effect of moxifloxacin in presence of 3 nM ATX-II is reduced by ranolazine, in a female rabbit isolated heart paced at 1 Hz. Representative LV monophasic action potentials MAP, top record in each panel ; and electrocardiograms ECG, bottom record ; recorded during A ; control no drug ; , B ; moxifloxacin 1 M ; alone, C ; ATX-II 3 nM ; alone, D ; ATX-II + moxifloxacin in absence and presence E ; of ranolazine, and after washout of ranolazine in the continuous presence of ATX-II + moxifloxacin F ; . Arrows indicate early afterdepolarizations, extra-ventricular beats and ventricular tachycardias.

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Seated position. Symptoms vary, but include lower back pain, pelvic pain, or groin pain with or without weight-bearing. The pain is usually severe and often makes ambulation extremely difficult to intolerable. Physical examination is commonly unremarkable except for possible sacral tenderness and limited lower back range of motion.1 A clinical clue may be the disparity between the patient's severe symptoms and the nearly absent clinical signs. Laboratory tests are usually normal. However, alkaline phosphatase levels are elevated above normal limits in up to one-third of cases.1 The best method of diagnosis is a high index of suspicion and Nuclear Medicine Imaging in the form of 99mTc-MDP bone scan. While sacral fractures are difficult to detect on plain radiographs due to vessel calcification and overlying bowel, bone scintigraphy is both highly sensitive and highly specific.3 Scintigraphy commonly displays a characteristic H-shaped delayed uptake pattern extending across the sacrum often referred to as the "Honda sign" in reference to the automobile manufacturer's emblem however, partial uptake patterns are also possible.4 Since associated vertebral compression fractures as well as pubic rami and iliac fractures are common comorbidities, whole-body bone scan has the added advantage of uncovering other unsuspected additional foci of injury.2 CT is sensitive but is not practical for extensive regional survey and may fail to detect transversely oriented fractures. MRI is also highly sensitive but has limited availability and its use may be limited in the elderly population since this form of imaging cannot be used for patients who have a pacemaker or other implanted metallic devices. CT and MRI are very useful imaging modalities should bone scintigraphy be equivocal.3 The treatment of sacral insufficiency fractures is conservative. Bed rest and non-narcotic analgesia is recommended until pain control is improved. Since sacral insufficiency fractures are stable, early exercise and ambulation with partial weight bearing using a cane or walker ; is suggested to avoid immobility, deconditioning and formation of deep vein thrombosis.1 Sacroplasty using percutaneous injection of polymethylmethacrylate PMMA ; under fluoroscopic or CT guidance has also been described in the literature.5 Results have been favourable, demonstrating faster pain relief and earlier return to function. Although further evaluation is necessary, sacroplasty may gain broader clinical acceptance in the near future. Once symptomatic improvement is observed, prognosis is good. Most patients return to their normal level of functioning within six to twelve months.1.

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