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The anklebrachial pressure index at the end of treatment increased on average from 060 to 067 in the sulodexide group and from 058 to 062 with placebo. The difference in the time course of anklebrachial pressure index changes approached statistical significance in favour of sulodexide P 0053 ; data not shown ; . Approximately 25% of the patients enrolled had type II diabetes. The average gain in pain-free walking Table 2 Serious adverse events.
The work area should be clearly designated for drug preparation and access restricted to authorised staff. Preparation is most appropriately undertaken by trained staff using a negative pressure pharmaceutical isolator with externally ducted exhaust filters. If such an isolator is not present than a suitably modified Class 2B Biological Safety Cabinet BSC ; may be used. These facilities should at least be annually validated. For details on BSC see Appendix 5 ; Notes: 1 ; Select a ventilated cabinet depending on the need for aseptic processing. Aseptic technique is important for protecting hazardous drugs from possible contamination. However, it is also important to consider worker protection and to assure that worker safety and health is not sacrificed. Therefore, when asepsis is required or recommended, use ventilated cabinets designed for both hazardous drug containment and aseptic processing. 2 ; When asepsis is not required, a Class I BSC or an isolator intended for containment applications a "containment isolator" ; may be sufficient. 3 ; Regardless of type, equip each ventilated cabinet with a continuous monitoring device to confirm adequate air flow before each use 4 ; Use a high-efficiency particulate air filter HEPA filter ; for the exhaust from these controls, and where feasible, exhaust 100% of the filtered air to the outside. 5 ; Install the outside exhaust so that the exhausted air is not pulled back into the building by the heating, ventilating, and air conditioning HVAC ; systems or by the windows, doors, or other points of entry. 6 ; Place fans downstream of the HEPA filter so that contaminated ducts are maintained under negative pressure. 7 ; Do not use a ventilated cabinet that recirculates air inside the cabinet or exhausts air back into the room environment unless the hazardous drug s ; in use will not volatilize evaporate ; while they are being handled or after they are captured by the HEPA filter. Information about volatilization should be supplied by the drug manufacturer. 8 ; Let a certified company check the safety cabinet annually to ensure proper working order. Eating, drinking, smoking, chewing gum, applying cosmetics and storing food in or near the preparation area should be prohibited. Closed or semi-closed systems should be used to prevent aerosol forming and control exposure to carcinogenic compounds. Note: 1 ; Special spike systems like those of Codan and Braun ; can be used. Other systems specially developed for the use of cytotoxic agents are recommended e.g. Oncovial and PhaSeal ; . Manipulation of oral or topical medicines containing cytotoxic drugs should be avoided if possible. If unavoidable, tasks such as dividing or crushing tablets should be restricted to a controlled environment such as a BSC, ideally within a pharmacy department. Carrying out these procedures on wards or in clinics should be actively discouraged. Note and imuran, for example, adderall xr.
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