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There is not much I can do in that village, " says Sister X, who assists self-help groups of people with HIV. "There, people with HIV AIDS have a difficult time getting organized, because local health centre staff don't welcome them. They miss a place to start from". "We have reflected on the factors involved in our psychological recovery after we had learned that we had HIV, " said a leader of a self-help group. "In each of our experiences, meeting a caring person is the key to our accepting our situation, and our moving on with our lives." 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Pylori ; Allergic Rhinitis Depression Smoking Cessation HIV Diabetes NIDDM, Type II ; Uncomplicated UTI Interventional Therapies Imitrex injection ; , Imitrex S oral ; , Imitrex nasal spray ; , Maxalt rizatriptan ; , Excedrin Extra Strength OTC ; Clotrimazole intravaginal ; 3 day Rx, Diflucan oral ; 1x Rx, Terconazole 0.8% Terazol 3 ; 3 day Rx, Butoconazole Femstat 3 ; 3 day OTC, Tioconazole 6.5% Vagistat-1 ; 1xOTC Lisinopril, Enalapril, Diovan, Cozaar Zocor, Pravachol, Lescol, Lipitor, Baycol, Cholestin Cognex, Aricept, Ginko biloba natural product ; Digoxin, Vasotec, Corge, Isosorbide dinitrate Bactrim, Ceclor, Augmentin, Biaxin, Amoxicillin Posicor, Sular, Procardia XL, Norvasc Proscar, Flomax, Cardura, Hytrin, TURP surgery ; Kytril, Zofran, Dexamethasone Metronidazole Amoxicillin H2 Antagonist, Helidac, Tritec Clarithromycin, Omeprazole Clarithromycin Chlorpheniramine, Claritin, Allegra, Zyrtec Amitriptyline, Paxil, Zoloft, Prozac Nicotrol NS spray ; , Nicorette gum-OTC, Zyban, Nicotrol patch-OTC Ritonavir Norvir ; , Saquinavir Invirase ; , Indinavir sulfate Crixivan ; , Lamivudine Epivir ; , Stavudine Zerit ; Glucophage, Precose, Rezulin, Glucotrol Maxaquin, TMP SMZ, Macrodantin, Floxin. TABLE OF CONTENTS . 2 ACKNOWLEDGEMENTS. 4 SUMMARY . 5 1. INTRODUCTION . 8 2. TARGETS AND MODE OF ACTION OF CURRENT TB DRUGS. 8 3. WHY NEW DRUGS ARE NEEDED? . 9 4. THE NEW TB DRUG PIPELINE . 12 4.1 Novel chemical entities. 13 Diarylquinoline TMC207 Johnson & Johnson ; . 13 Nitroimidazole PA-824 Chiron Corp.-TB Alliance ; . 14 Nitroimidazole OPC-67683 Otsuka Pharmaceuticals, Japan ; . 15 Pyrrole LL- 3858 Lupin Limited, India ; . 16 Pleuromutilins GlaxoSmithKline-TB Alliance Partnership ; . 16 Dipiperidine SQ-609 Sequella Inc. ; . 16 ATP Synthase Inhibitor FAS20013 FASgene ; . 17 Translocase I Inhibitor Sequella Inc. ; . 17 InhA Inhibitors GlaxoSmithKline-TB Alliance ; . 17 Isocitrate Lyase Inhibitors GlaxoSmithKline-TB Alliance ; . 17 4.2 Compounds originating from existing families of drugs . 18 Using existing Fluoroquinolones for TB ? . New Quinolones . 22 Non-fluorinated quinolones. 23 Diamine SQ-109. 23 Macrolides. 23 Thiolactomycin analogs . 23 Nitrofuranylamides . 24 Nitroimidazole Analogs . 24 4.3 Summary of the drug pipeline. 25 5. EXPECTED TIMELINES TOWARDS APPROVAL FOR NEW CANDIDATE DRUGS . 27 6. CRUCIAL GAP: LACK OF EARLY STAGE DRUG DISCOVERY . 29 7. DISCUSSION AND CONCLUSIONS . 32 Pressing needs still remain. 32 Time to sow new seeds now as all the low-hanging fruit have been eaten . 36 APPENDIX A: PROMISES FROM THE BASIC RESEARCH FIELD . 38 Genes involved in energy metabolism and response to oxygen limitation . 39 Genes encoding enzymes of the glyoxylate shunt . 40 Genes involved in the response to nutrients limitation . 41 Genes involved in cell wall and membrane metabolism. 42 Genes involved in transcriptional regulation 43 Genes involved in promoting M. tuberculosis survival inside macrophages 44 Inhibition of phagosome maturation. 44 Resistance to nitric oxide stress . 45 APPENDIX B: UPDATE ON COMPOUNDS IN THE PIPELINE . 46 Malate Synthase Inhibitors GSK, Rockefeller University, Texas A&M ; . 46 Riminophenazines Institutes of Materia Medica BRTI ; . 46 Capuramycins Sankyo Sequella ; . 46 2.Costochondritis 733.6 ; is an inflammation of the costochondral junction between the sternum breastbone ; and the ribs that can sometimes result from an injury or strain to the chest muscles. The etiology can also be unknown. Symptoms include a sharp anterior wall chest pain that can sometimes be similarly described in patients with coronary artery disease. This confusion of the symptoms of costochondritis with those of heart disease can sometimes result in patient admission. However, diagnostic studies such as chest radiograph, electrocardiogram, and blood chemistry e.g., troponin and creatine kinasemyocardial band are laboratory tests that can identify myocardial damage ; typically rule out the possibility of serious cardiac disorders in these cases. Costochondritis is a self-limiting condition. Medical treatment includes NSAIDs, and the pain usually resolves within a short time. |
In my opinion, the Mangosteen extract equals or outperforms the following prescriptions and over-the-counter drugs: Nexium, Prevacid, Aciphex Zantec, Pepcid, other H2 blockers Allegra, Zyrtec, Claritin, other antihistamines Singulair Prednisone Lotrisone, Topicort, Cutivate, other topical corticosteroids Valium, Xanax, other minor tranquilizers Tegretol, Neurontin, other anti-epileptic drugs when used for chronic pain Anusol, other hemorrhoid preparations Prozac, Zyloft, Paxil, Lexapro, other anti-depressants when used for dysthymia or anxiety Vicodin, Percocet, Duragesic patches, other narcotics Celebrex, Vioxx, Bextra, Naproxen, Arthrotec, Ibuprofen, other antiinflammatories Ultram, Talwin, other non-opiod pain preparations Midrin, Fioricet, Imitrex, Amerge, Maxalt, Zomig, other migraine preparations Lupitor, Zocor, Pravacol, other lipidlowering agents Valtrex Aricept, Cognex, other Alzheimer's preparations * Health Journal 44 Number 1 Compliments of Dr. Fred Templeman. 179. Chen, H.W., Leonard, D.A., Fischer, R.T., Trzaskos, J.M. 532. Cmarik, J.L., Inskeep, P.B., Meredith, M.J., Meyer, D.J., Ketterer, B., Guengerich, F.P. 1254. Cook, C.S., Ames, G.B., Smith, M.E., Kowalski, K.G., Karim, A. 212. Covey, D.F., McMullan, P.C., Wixler, L.L., Cabell, M. 161. Crooks, P.A., Godin, C.S., Damani, L.A. 368. Damani, L.A., Shaker, M.S. 404. Damani, L.A., Shaker, M.S., Godin, C.S., Crooks, P.A., Ansher, S.S., Jadoby, W.B. 661. Daubner, S.C., Lauriano, C., Haycock, J.W., Fitzpatrick, P.F. 721. Davis, K.L., Dunn, M.W., Schwartzman, L.S. 1366. DeGeorge, G.L., Heck, D.E., Laskin, J.D. 1018. Delos, S., Iehle, C., Martin, P-M., Raynaud, J-P. 698. Ding, X., Coon, M.J. 699. Ding, X., Coon, M.J. 673. Dix, T.A., Fontana, R., Panthani, A., Marnett, L.J. 397. Eling, T.E., Curtis, J.F., Harman, L.S., Mason, R.P. 210. Elliott, W.J., Morrison, A.R., Sprecher, H., Needlemen, P. 766. Ericsson, J., Runquist, M., Thelin, A., Andersson, M., Chojnacki, T., Dallner, G. 828. Ericsson, J., Thelin, A., Chojnacki, T., Dallner, G. 806. Ericsson, J., Thelin, A., Chojnacki, T., Dallner, G. 1320. Faletto, M.B., Miller, W.H., Garvey, E.P., St.Clair, M.H., Daluge, S.M., Good, S.S. 68. Ferone, R., Singer, S.C., Hunt, D.F. 990. Fisher, C.W., Caudle, D.L., Martin-Wixtrom, C., Quattrochi, L.C., Tukey, R.H., Waterman, M.R., Estabrook, R.W. 28. Fong, K.-L.L., Hwang, B.Y.-H. 326. Foureman, G.L., Harris, C., Guengerich, F.P., Bend, J.R. 221. Gaines, D.W., Friedman, L., McCann, P.P. 789. Garver, W.S., Kemp, J.D., Kuehn, G.D. 485. George, R.J., Haycock, J.W., Johnston, J.P., Craviso, G.L., Waymire, J.C. 667. Gilmour, S.J., Bleecker, A.B., Zeevaart, J.A.D. 666. Gilmour, S.J., Zeevaart, J.A.D., Schwenen, L., Graebe, J.E. 203. Greenspan, M.D., Yudkovitz, J.B., Alberts, A.W., Argenbright, L.S., Arison, B.H., Smith, J.L. 934. Grem, J.L., McAtee, N., Steinberg, S.M., Hamilton, J.M., Murphy, R.F., Drake, J., Chisena, T., Balis, F., Cysyk, R., Arbuck, S.G., Sorensen, J.M., Chen, A.P., Goldstein, L., Jordan, E., Setser, A., Goldspiel, B., DeCarvalho, M., Allegra, C.J. 586. Gruys, K.J., Walker, M.C., Sikorski, J.A. 583. Guengerich, F.P., Kim, D.-H. 270. Guillemette, G., Balla, T., Baukal, A.J., Catt, K.J. 866. Guo, Z., Smith, T.J., Thomas, P.E., Yang, C.S. 540. Haaf, H., Metzler, M., Li, J.J. 273. Hanlon, M.H., Ferone, R., Mullin, R.J., Keith, B.R. 958. Hansbro, P.M., Foster, P.S., Hogan, S.P., Ozaki, Sl, Denborough, M.A. 1099. Hissong, B.D., Byrne, G.I., Padilla, M.L., Carlin, J.M. And more identifiable as an injury. The forensic examiner can then photograph the area. The dye is not systematically absorbed and is thus completely safe. It can be used on pregnant females for the same reason. Colposcope - A special microscope may be used to visualize the hymen, the cervix, and the vaginal walls. It can have a binocular or monocular magnification system that is fixed or adjustable with capability to document through video or still photography. The colposcopic images can be digitally preserved for injury documentation and later reproduction for introducing the injuries into evidence.
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