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Jim, this girl had had a long history of disease. Perianal disease in children, 6MP. Are you successful in controlling it? JAMES MARKOWITZ, MD: Well, I guess it depends on the kind of perianal disease. I think that florid ulcerating tags don't respond all that well to 6-MP. There is some data to suggest that 6-MP prevents the development of new abscesses and fistulas, although you certainly can still see them. I think it's the treatment that we would all use, although often the perianal disease will progress despite that. WILLIAM J. TREMAINE, MD: Certainly, this girl's disease predated infliximab. Now we've seen infliximab around for five years or more. Is your enthusiasm for using it in children tempered any by risks? What's your threshold for when you decide to add infliximab with a child who's not doing well with 6-MP? JAMES MARKOWITZ, MD: Well, I think as pediatricians we're all very concerned about the potential long-term risks of the drug, especially because we don't yet have published data to tell us much about that age group. On the other hand, we. If an overdose of arava is suspected, the patient should receive prompt medical assessment and axid. The provisions of this Act shall also apply to loans granted in accordance with the Acts of December 15, 1989 and December 21, 1990 on Amending the Housing Production Act 1140 89 and 1185 90 ; and the Act on Granting Purchase Loans under the Housing Production Act in certain cases 412 92 ; . The provisions in sections 12, 20, 25, and 37 of this Act concerning a competent authority shall apply, regardless of what may have been provided in a promissory note in these respects, to all loans granted under the following laws: a 1 ; Act on Housing Loans, Guarantees and Grants of March 29, 1949 224 2 ; Act on Supporting Housing Construction in Population Centres with State Funds of March 29, 1949 226 3 ; Housing Production Act issued on December 4, 1953 488 4 ; the 1966 Housing Production Act, except for loans referred to in paragraph 1; 5 ; Housing Renovation Act of January 19, 1979; and 6 ; Act on the Redemption of Rental Housing of January 25, 1982 82 ; . The right under the acts referred to in paragraph 2 above to alter the interest rates on housing loans by decree or Council of State decision shall still remain in force. What has been provided on each loan in a promissory note shall otherwise apply to the terms of these loans. Any restrictions on use and assignment of housing financed by loan that are entered in land and mortgage registers and articles of association, share certificates and promissory notes concerning owner-occupied ARAVA housing and dwellings subsidized under the Act on interest subsidy for loans for home purchase granted in place of a State loan 76 89 ; shall not, however, apply once this Act comes into force. If a State guarantee or other comparable obligation as referred to in section 13 or 13a of the 1966 Housing Production Act has been granted or concerns a loan referred to in this section, it shall remain in effect as such. Section 46 Amortization of, interest on and postponements of certain loans The maximum loan period for a renovation loan and a personal State housing loan granted in accordance with the laws referred to in section 45, paragraph 2, is 25 years unless. 3 crossed the Dead Sea Transform DST ; in the A4ava valley about 70 km south of the southern end of the Dead Sea. From an analysis of the compressional P ; wave data, a 2-D P-wave crustal model beneath the profile has been derived Weber et al. 2004 ; . The purpose of this study is to present a 2-D shear S ; wave model from an analysis of the S-wave data. Having information about both the P and S-wave crustal velocities provides much better constraints on the gravity and petrological models, which have been derived by El-Kelani et al. 2003 ; and Frster et al. 2004 ; respectively, in the region of the profile. The DESERT 2000 wide-angle reflection refraction experiment comprised on the source side two large quarry blasts of 8500 kg shot 10 in Fig. 1 ; and 12000 kg shot 31 in Fig. 1 ; , five large borehole shots of 720-950 kg shots 1, 3, 5, and 9 in Fig. 1 ; and six small borehole shots of 30-80 kg shots 2, 4, 41, and 8 in Fig. 1 ; . Whereas the purpose of the large shots and the quarry blasts was to obtain arrivals from the whole crust including the Moho reflection and, if possible, the first arrival refraction through the uppermost mantle, the purpose of the small shots between the large shots was to obtain extra information on the structure of the top of the seismic basement and the overlying cover rocks. The 13 shots were recorded by 99 three-component instruments spaced 1-4.5 km apart along the whole length of the profile and 125 vertical-component geophone groups spaced 100 m apart along a 12.5 km section of the profile between shots 5 and 51 in the Arvaa valley Fig. 1 ; . For the 99 threecomponent instruments, the closest station spacing of 1 km was achieved in the Aravz valley where high ambient noise levels were expected. On the shoulders adjacent to the Qrava valley where the reflection from the crust-mantle boundary Moho ; was expected to be well recorded at around the critical distance, the station spacing was about 2.5 km. Further out, at the ends of the profile the station spacing was 4-4.5 km. As the sources were quarry blasts and borehole shots on land and as three-component recordings were made along the whole profile, good quality S-wave data were recorded in addition to the P-wave data. From the distribution of observation distances Fig. 2 ; , it can be seen that all the large borehole shots and the two quarry blasts recorded the S-wave reflection from the Moho. Previous crustal-scale wide-angle reflection refraction profiles in the region include those in Israel in 1977 Ginzburg et al. 1979a, b ; , the onshore-offshore profile between the NW end of the DESERT profile and Cyprus in 1978 Makris et al. 1983; Ben-Avraham et al. 2002 ; and those in Jordan in 1984 El-Isa et al. 1987a, b ; . The majority of these profiles trended approximately N-S and none of them crossed the DST. Those in Israel, including the N-S profile along the Jordan-Dead Sea-Arava valley associated with the DST, used sea shots as the main source of energy, whereas those in Jordan used quarry blasts as the main source of energy. As a result, whereas it was possible to derive a crustal-scale S-wave model for Jordan El-Isa et al. 1987b ; , no crustal-scale S-wave model was derived from the 1977 and 1978 profiles for the region west of the DST. Thus the DESERT profile provides for the first time and azelaic. 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Kocaeli University Faculty of Medicine, Department of [1] Physiology, Department of [2] Biochemistry, Kocaeli, Turkey. gonulgurol superonline Although the effects of acute and chronic administration of ethanol on the generalized convulsive epilepsy are well known, its effects on the nonconvulsive generalized epilepsy are not well known. Therefore, we aimed to investigate to the acute and subchronic administration of alcohol on SWD spike-wave discharges ; in genetically absence epileptic WAG Rij rats. Following a one-hour-record of basal EEG electroencephalogram ; activity in all groups, 50 mg kg, 250 mg kg, and 1 g kg, i.p. alcohol was injected to the rats in acute alcohol groups, and %0, 09 serum physiologic was injected to the rats in control group. Then the EEG records were continued for three hours. Ethanol was injected i.p. intraperitoneal ; subchronically to the group, on which the effects of subchronic alcohol were investigated, twice daily during the periods of 13 days. After an hour, the EEG records were done. Following an abstinence period of 12 hours, EEG records were done for an hour at fourteenth day. After the last alcohol injection fourteenth day EEG records were done and analyzed for the evaluation of the number and total duration of SWD. Spontaneous behaviors of rats were also observed before and after an alcohol administration. Their horizontal locomotor activities were recorded automatically. After the records, blood samples were taken to determine their blood alcohol levels. According to our results, acute and chronic administrations of alcohol significantly decrease to the occurrence of the SWD. However, abstinence period of twelve hours increase both of the number and duration of SWD significantly. On the other hand, our results also showed that administration of low level alcohol increased locomotor activity, whereas high dose and chronic alcohol administration reduced locomotor activity p 0, 05 ; . Our results showed that, alcohol can induce a decrement in absence epileptic seizure by changing the consciousness level and modulating excitatory neurotransmitter system. Key words: electroencephalogram; epilepsy, absence ; ethanol; models, genetic P69 Isolation and culture of adult mouse medial vestibular nucleus neurons Him A, Altuntas S, Ozturk G. Yuzuncuyil University, Medical School, Department of Physiology, Van, Turkey. ahim yyu .tr Primary culture of vestibular nucleus neurons has only been successfully described in embryonic and early postnatal ages. This study describes a method for culture of vestibular nucleus neurons from young adult 6-8 weeks ; mice. The culture system is based on Neurobasal medium supplemented with antioxidant rich B27. Neuronal survival was optimized by replacing glutamine with GlutaMaxI and by using ice-cold culture medium to increase neuronal survival during tissue dissection. Density gradient was used for enrichment of neurons and to separate neurons from debris and nonneuronal cells. Neuronal survival was increased in culture supplemented with fetal calf serum FCS while neuronal survival in culture without the serum was 69%, 11% and 5% at 1, 2, and 3 days in vitro div ; , respectively, neuronal survival in culture with %20 FCS were 92%, 68% and 33% at 1, 2, 3 div, respectively. Supplementing the medium with 10% FCS was less effective; neuronal survival in culture with %10 FCS was 92%, 29% and 1% at 1, 2, 3 div, respectively. From the first day in culture some neurons grew neurites. Using FCS in medium increased the number of neurons with neuritis; while 2% of the neurons grew neurites in the medium without FCS at 24 h culture, 8% of the neurons grew neurites when 20% FCS supplement was used. The neurons with neurites survived longer in culture. Key words: medial vestibular nucleus, neuron, culture, mouse, adult. 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If, however, the object of the loan is a building of historical or architectural value or the loan was granted for the conversion into a residential building of a building previously used primarily for purposes other than residential, the rate of interest shall, until further notice, be the change in the consumer price index plus 2 percentage points. Section 38a. 8.12.1995 1403 ; Maximum interest charged on ARAVA loans for rental housing. These groups call for the local or worldwide ban or discontinuation of arava. 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NEWS FROM EUROPE European Section Surveillance of Wildlife Diseases on the European Scale. M. ARTOIS1, T. MORNER2, P. DUFF3 and D. SIBARTEE4. In recent decades the movement and translocation of wildlife, including zoo animals, domestic and free-ranging wildlife, has increased worldwide. To reduce the risk of introducing new diseases into new areas and animal populations, significant diseases of wildlife in different parts of the world have been reported annually to a permanent Working Group of the OIE. The OIE, Office International des Epizooties or World Animal Health Organisation, is an intergovernmental international organisation based in Paris, France. Its main duty is to secure international trade in animals and their products by harmonisation of regulations and by informing the OIE Delegate of each Member Country often the Chief Veterinary Officer of the country ; of outbreaks of disease. In 1992, on the initiative of its former Director General, Dr Jean BLANCOU, an ad hoc group of experts on diseases of wildlife was created. This group has sent a questionnaire to all OIE Delegates asking them to report on the main diseases that were occurring in their country. Animal diseases are listed by the OIE according to their seriousness and contagiousness. Among list A diseases, classical swine fever CSF ; in European wild boar, foot and mouth disease FMD ; in hoofed mammals, and paramyxovirus PMV1 ; serological traces were regularly reported. Among list B diseases, bovine tuberculosis TB ; and rabies are also reported frequently in a wide range of species across Europe. The Working Group has also established a `Wildlife list' including diseases that cause, or can cause, serious problems for wildlife conservation. It is noteworthy that in Europe, wild boar CSF and carnivore rabies still cause significant morbidity, as does sarcoptic mange in many species. The reporting of wildlife diseases in Europe is mainly based on a collection of data carried out by members of the European section of the Wildlife Disease Association EWDA ; , through a network of contacts in each country. In 2002 information has been collected from 24 countries. The individual country reports are increasingly detailed with referencing of incidents and comment on significant incidents. Important events this year included the Phocine Distemper virus outbreak in Common Seals in the North and Baltic seas and the mass mortality of Schreiber's long fingered bat Miniopterus schreibersi ; , from an, as yet, unknown cause. Wildlife disease may also be important for preservation of game resources and an example of this was a previously un-reported condition affecting the nervous system and skin of Pyrenean chamois, again of unknown cause. `Emerging diseases' in wildlife, for example, West Nile Fever and Lyme borreliosis are increasingly recognized by statutory authorities across Europe as being of growing importance. Surveillance for these wildlife diseases increases our global knowledge and allows comparisons of the monitoring and control Ecole Nationale Veterinaire de Lyon, France The national veterinary institute, Uppsala, Sweden 3 Veterinary Laboratories Agency, Merrythought, Penrith, Cumbria, UK 4 Office International des Epizooties, Paris.
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