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Agenix is a Brisbane-based biotechnology company. The company's wholly owned subsidiary, AGEN Biomedical, was a spin out from the Queensland University of Technology on the basis of the discovery of the D-dimer monoclonal antibody, 3B6. D-dimer is generated when the body develops and breaks down blood clots. Agenix is developing ThromboView, an innovative blood-clot imaging technology targeting a global unmet medical need in the diagnosis of blood clots. A Phase II clinical trial for ThromboView in detection of PE is due to commence in early FY08 in the US. Promising results have been demonstrated in earlier phase studies for detection of both PE and DVT. Agenix has recently acquired, for A$16.5M, Chinese biopharmaceutical company SHRG, which has a pipeline of anti-viral drugs in development. The most advanced of these, an anti-hepatitis B virus drug YHD, has successfully completed Phase III clinical trials and is awaiting market launch. Revenue is expected to commence in the second half of calendar year 2007. Agenix completed a fully underwritten rights issue in May 2006, raising A$6.7M for the sales and marketing launch of YHD. Agenix has an independent valuation of SHRG, including a GMP manufacturing facility, of around A$56M. The valuation does not include pre-clinical products in development, which include an anti-colon cancer drug, a second generation hepatitis B virus drug, an anti-HIV drug and an anti-liver cancer drug. The GMP manufacturing facility has the capacity to manufacture 50 million tablets per annum. Do you take birth control pills? . No Yes, for example, drug interaction. 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NOTE: INH Syrup should not be refrigerated keep at room temperature ; . INH tablets can be crushed for oral administration. INH tablets are also scored. Table 2. Pharmacokinetic PK ; parameters geometric least squares means, treatment ratios and 90% confidence intervals [CIs] ; of TMC278 with and without tenofovir disoproxil fumarate TDF ; n 15 and ascorbic. After oral administration, the drug kinetics was linear in the administered dose range and the pharmacokinetic parameters were as follows: c max 30 mg ; , 4 1 8 ng ml; c max 60 mg ; , 8 7 1 ml; c max 90 mg ; , 13 6 1 ml; auc 30 mg ; , 119 25 ng h ml; auc 60 mg ; , 256 48 ng h ml; and auc 90 mg ; , 389 54 ng h.

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Peak plasma concentrations for Ccaduet are achieved within six to 12 hours. For amlodipine and atorvastatin, peak plasma concentrations are reached within one to two hours. All remaining parameters are the same as for the products individually and chlorthalidone.

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Cheng, X.L., et al: Chinese Acupuncture and Moxibustion, Foreign Language Press, Beijing, 1987 Weith, I.: The Yellow Emperor's Classic of Internal Medicine, University of California Press, 1972 Yang, Y.Y.: The History of Chinese Medicine, Hebei Scientific Press, China, 1994 In Chinese ; Wang, Samuel: The Research Methodology of TCM, Acupuncture & Herbal Center Publications, 1999 Chen, Y. et al: Essentials of Contemporary Chinese Acupuncturists' Clinical Experiences, Foreign Language Press, Beijing, China, 1989 Liu, G.W., et al: Clinical Acupuncture & Moxibustion, Tianjing Science & Technology Translation & Publishing Corp., 1998 Maciocia, G.: The Foundations of Chinese Medicine, Churchill Livingstone, 1989 Pernoll, M, et al: Current Obstetric & Gynecologic Diagnosis and Treatment, 7th Ed., Appleton & Lange, 1991 Shangdong College of TCM: Selected Historical Theories of TCM, Shangdong Scientific Press, 1983 In Chinese ; Zhou, F.W., et al: Interpretations of Huang Di Nei Jing, Shangdong Scientific Press, 1985 In Chinese ; Chin, S.D., et al: Lecture Notes of Neijing, Shanghai Scientific Press, 1988 In Chinese ; Meng, J.C., et al: Introduction to TCM, People's Health Press, 1987 In Chinese ; Wang, Z.M.: Zhuyuntang in the Treatment of Infertility, Journal of New TCM, P 35, Vol 9, 1984 In Chinese ; Zhang, Z.X., et al: Treatment of Infertility in 3 stages of the menstrual scycle, Journal of New TCM, P 40, Vol 11, 1998 In Chinese ; Liu, M.C., et al: Essentials of TCM treatment of Modern Difficult Diseases, Guangdong Scientific Press, 1996 In Chinese ; Yu, J., et al: Clinical Studies of Electro Acupuncture in the Promotion of Ovulation, Symposiums of the 3rd National Conference of Integration of TCM and Western Medicine in Ob & Gyn, P44-49, 1990 In Chinese ; Xiao, Y.J., et al: Acupuncture Treatment of 62 different Joint Diseases, Chinese TCM Press, 1997 In Chinese ; Wang, F.C., et al: A Complement Work of Contemporary Therapeutics of Micro Acupuncture, Scientific Literature Press, 1997 In Chinese ; Hu, X.L., et al: A Complete Work of Special Acupuncture points, Jiangshu Scientific Press, 1997 In Chinese ; Xuai, X.Z., et al: Chinese-English Terminology of TCM, Hunan Scientific Press, China, 1983 Yang, J.Z., et al: Great Compendium of Acupuncture and Moxibustion, Edited by Heilongjiang TCM Research Institute, People's Health Press, 1984 In Chinese. 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Medical authenticity by: Gabriel G. Nahas MD, PhD Department of Anesthesiology College of Physicians and Surgeons Columbia University Robert H. Heath MD Psychiatry and Neurology Tulane University Medical Center Akira Morishima MD Division of Pediatric Endocrinology College of Physicians and Surgeons Columbia University Forest S. Tennant Jr. MD, DPH Director community Health Projects West Covina, California, for example, patient information. Insulin-Like Growth Factor-I Although rhIGF-I seems to be a logical treatment for growth failure in pediatric CRF, because of the increased IGFBP in this condition, clinical studies with rhIGF-I have not been performed in children outside of patients with GH insensitivity syndrome GHIS ; . Studies in animal models of CRF 5 6 nephrectomy ; show that the growth response after rhIGF-I treatment is almost comparable to that after GH treatment 56 ; . Besides effects on stature, rhIGF-I has direct anabolic effects and improves renal function. In normal subjects, rhIGF-I rapidly increases GFR and renal plasma flow by approximately 30% 57 ; . Acute Renal Failure. No drug has been approved as a stimulator of renal function in acute renal failure ARF ; 58 ; . However, there is an obvious need for new treatments, as morbidity and mortality remain high after ARF. In animal models, rhIGF-I can improve both functional and histologic recovery after renal ischemia and reperfusion damage 59 ; . These beneficial effects may be due to a variety of actions, such as increasing anabolism and hemodynamic effects in the glomerulus and the preglomerular vessels. RhIGF-I decreases both afferent and efferent arteriolar resistance in the glomeru-lus and increases renal blood flow by dilation of preglomerular vessels. These effects most likely are mediated by nitric oxide and vasodilatory prostaglandins 15 ; . Recent studies also have shown that rhIGF-I can reduce the inflammatory process after renal ischemia and reperfusion by inhibiting apoptosis 60 ; . Early timing of treatment may be crucial for these effects, although other studies have shown that rhIGF-I treatment can enhance renal repair when administered up to 24 after injury 59 ; . These advantageous effects of rhIGF-I administration in animals have led to two randomized, doubleblind, placebo-controlled trials 61 ; . Franklin et al. 62 ; examined the effects of rhIGF-I on recovery of renal function in 58 patients who underwent vascular surgery of the renal artery or the aorta, and Hirschberg et al. 63 ; tested rhIGF-I in 72 intensive care unit patients with confirmed ARF from different causes. Overall, both studies failed to show clinically significant effects on renal function or outcome. The disappointing results of these clinical studies in ARF are in contrast to the very positive results in equivalent animal models. These differences are difficult to explain. It seems unlikely that there will be additional studies to test rhIGF-I in human ARF, although the lack of other candidate drugs suggests that IGF-I does deserve additional testing in humans. Chronic Renal Failure. No drug has been approved for use in patients with CRF and ESRD to stimulate renal function or to delay the need for dialysis 64 ; . The positive effects of rhIGF-I on renal function in healthy subjects led to several studies in CRF patients. Initial studies with high doses of rhIGF-I 100 g kg twice a day ; increased renal function for several days but caused serious side effects 65, 66 ; . Recently, studies by Vijayan et al. 67 ; showed in patients with ESRD that efficacy could be maintained and side effects could be reduced with the use of an intermittent treatment regimen 4 d on treatment, 3 d off treatment ; for rhIGF-I 50 g kg per d ; . This approach was well tolerated and resulted in a sustained improvement in renal function, which may be related to the IGFBP's being relatively unaffected by this mode of delivery. In other human studies, large rises in IGFBP-2 seem to be related to overdosing and the occurrence of side effects 68 ; . Additional rhIGF-I treatment studies, particularly in CRF in children, seem justified. However, the current limited interest by pharmaceutical companies and the lack of availability of clinical grade rhIGF-I make this unlikely. Combination Treatment with GH Plus IGF-I or IGF-I Plus IGFBP-3 Studies of combinations of hormones, in animals with the use of GH plus rhIGF-I 29, 56 ; or in humans with rhIGF-I plus IGFBP-3 69 ; , suggest that there may be advantages in terms of efficacy and safety for combination therapy. The combination of rhGH plus rhIGF-I has been tested in catabolic states in and azathioprine.

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3. Plaisant, P., Rose, A. 1996 ; Exploring LifeLines to Visualize Patient records. Poster summary in 1996 American Medical Informatics Association Annual Fall Symposium, pp. 884, AMIA, Bethesda MD. 4. Whiting-O'Keefe, Q.E., Simbork, D.W., Epstein, W.V., Warger, A. 1985 ; A Computerized summary medical record system can provide more information than the standard medical record. JAMA, 254, pp. 11851192 5. Factor, M., Gelernter, D.H., Kolb, C.E., Miller, P.L., Sittig, D.F. 1991 ; Real-time data fusion in the intensive care unit. IEEE Computer, November 24, pp. 45-54. 6. Tufte, E.R., 1983 ; The Visual Display of Quantitative Information. Graphics Press. Cheshire, Connecticut. 7. Powsner, S.M., Tufte, E.R., Graphical summary of patient status. The Lancet, 344 Aug 6, 1994 ; 386-389 8. Kilman, D., Forslund, D. 1997 ; An international collaboratory based on virtual patient records, Comm. of the ACM, Vol. 40, 8 Aug. 97 ; , pp. 111-117. 9. Cousins, S., Kahn, M. 1991 ; , The visual display of temporal information, Artificial Intelligence in Medicine 3 , 341-357 10. Plaisant, C., Milash, B., Rose, A., Widoff, S., Shneiderman, B. 1996 ; LifeLines: Visualizing Personal Histories. Proc. of Human-Factors in Computing Systems, CHI' 96, ACM, New York. 11. Lindwarm D., Rose, A., Plaisant, C., and Norman, K. 1998 ; Viewing personal history records: A comparison of tabular format and graphical presentation using LifeLines, Behaviour & Information Technology to appear ; . 12. Rose, J.R., Gapinski, M., Lum, A., Pote et, J., Hushka, G. 1998 ; The Rocky Mountain Kaiser Permanente Clinical Information System, a computerized ambulatory electronic health record in large scale: strategy, vision, functionality, architecture, management, implementation, impact, and lessons learned, accepted for presentation at TEPR, San Antonio, TX, May 9-16, 1998 ; . 13. Plaisant, C., Shneiderman, B., Mushlin, R., 1998 ; An information architecture to support the visualization of personal histories. International Journal of Information Processing and Management to appear, 1998. Functional class formulations tablet, capsule, inhaler, etc. ; duration of use chronic vs. acute ; drug age in 2001 generic availability in 2001 degree of DTC promotion manufacturer.
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