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PHASE I TRIAL OF CPT-11 PLUS BCNU IN MALIGNA NT GLIOMA Friedman HS, Quinn JA, Tourt-Uhlig S, Albergo G, Rich JN, Cokgor I, Stewart E, Affronti ML, Provenzale JM, McLendon RE, Gururangan S, Buchanan W, Parker R, Colvin OM, Bigner DD, Beason R, Sampson J, Haglund M, Friedman AH, Miller L; Duke University Medical Center, Durham, NC; Pharmacia and Upjohn, Nashville, TN CPT-11 Irinotecan ; is a topoisomerase I inhibitor previously shown to be active in the treatment of malignant glioma MG ; Friedman et al, J Clin Oncol. 1999; 17: 15161525 ; . Irinotecan has attracted much attention as a new type of cancer chemotherapeutic agent due to its unique mechanism of action, the inhibition of DNA topoisomerase I, an enzyme thought to be necessary for DNA replication. Furthermore, treatment of human MG xenografts in athymic nude mice with CPT-11 and BCNU has revealed enhanced activity Coggins et al, Cancer Chemo Pharmacol. 1998; 41: 485; Castellino et al, Cancer Chemo Pharmacol. In press ; . These results suggested that a combination of these two agents may produce enhanced anti-neoplastic activity against human glioma and provided the rationale for the current phase I trial. We now report interim results of a phase I trial of CPT-11 plus BCNU for patients with recurrent MG. Patients were stratified into anti-convulsant dilantin, tegretol or phenobarb ; or no anti-convulsant use. BCNU is administered at a dose of 100 mg m2 over 1 hour every 6 weeks on the same day as the first irinotecan dose i.e. week 1, 7, etc. ; . Irinotecan is administered intravenously over 90 minutes once weekly. A treatment cycle consists of 4 weekly administrations of irinotecan followed by a two week rest. Every effort is made to eliminate delays between treatments. The dose of CPT-11 escalates in cohorts of 36 patients, starting at 25 mg m 2 . Sixty-one patients have been treated, 44 with anti-convulsant use and 17 with no anti-convulsants. The maximal tolerated dose MTD ; for patients not on anti-convulsants appears to be 125 mg m 2 . The MTD. Received Aug. 1, 1974; revision accepted Sept. 19, 1974. For reprints contact: Ray R. Quinto, Nuclear Medicine Service, VA Hospital, 3350 La Jolla Village Dr., San Diego, for instance, dilantin and alcohol. What You Should Do If You Think You Or A Friend Might Have Bacterial Meningitis? Seek prompt medical attention. For More Information: Your school nurse, family doctor and the staff at your local or regional health department office are excellent sources for information on all communicable diseases. You may also call your local health department or Regional Texas Department of Health office to ask about meningococcal vaccine. Additional information may also be found at the web sites for the Centers for Disease Control and Prevention: cdc.gov and the Texas Department of Health: tdh ate.tx.

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The end points of uterine wet weight and uterine adenocarcinoma at these ages. To emphasize this point, previous work from Newbold's group has demonstrated that exposure of neonatal mice to a 10-fold lower dose of genistein 5 mg kg ; resulted in the development of multi-oocyte follicles by 2 months of age 5 ; , an effect that is likely to compromise fertility. Yet, a 3-day exposure of prepubertal mice days 1719 ; to 50 mg kg genistein was insufficient to induce a uterotrophic response 6 ; . Thus, for the parameter of multi-oocyte follicles, the uterotrophic assay is not predictive. Third, induction of adenocarcinoma is the most extreme of biological end points to consider, particularly in a field that is attempting to tease out the subtleties of biological perturbations due to chemical exposure in populations characterized by variation. Again, to emphasize this point, Newbold 7 ; demonstrated that exposure of CD-1 mice to 100 g kg DES on gestational days 916 induced uterine adenocarcinoma; yet a dose of DES that was 10, 000-fold lower 0.01 g kg ; resulted in reduced reproductive capacity. By using the uterotrophic assay to establish the estrogenicity of bisphenol A BPA ; , it can be concluded that exposure to a dose 100 mg kg day is not detrimental to CD-1 mice. However, exposure of the same strain of mice during gestational days 920 to doses of BPA 4, 000 times lower 25 g kg day ; induced profound proliferative changes in the lobuloalveolar network of the adult mammary gland 8 ; . We also observed the persistence of epithelial structures that have been shown to be sites of neoplasia in rodents and humans, and an alteration in DNA synthesis between the epithelium and stroma, which is the substratum of neoplasia in this tissue 8 ; . Ashby's statement that there is "insufficient genistein in soy-based infant formula to trigger a uterotrophic response in rodents" which "indicates the probable absence of a carcinogenic hazard" leads him to conclude that the dose of genistein found in infant formula is not of biological concern. This rationalization clearly demonstrates the dangerous misuse of the uterotrophic assay that we pointed out in our paper in Environmental Health Perspectives 9 ; . Newbold et al. support our findings that "many cellular and biochemical end points in the uterus . are often more sensitive end points than wet weight increase, " yet they disagree with our purported conclusion that the uterotrophic assay has limited value. We concluded that "the uterotrophic assay is of limited value in assessing the estrogenicity of a suspected environmental estrogen" 9 ; , and we maintain this position on the basis of our and effexor, for example, dilantin syndrome.
Knees Neck Jaw Arms 46. Have you awakened with an injury to yourself that was not there when you went to bed, or have bed partners said you injured them in your sleep, but you have no recollection of such behaviors? Yes Have you discovered or been told you were up recollection of having done so. Do you often have trouble falling asleep? If yes, how many nights a week? How long does it take you to fall asleep? Once asleep, do you have trouble staying asleep? Approximately how many times a night do you remember waking up? Do you have trouble going back to sleep if you wake up? What remedies have you tried to help you sleep? REMEDY Sleeping pills YES How often? What kind? Yes No Yes No walking, or. Patrice chemotherapy via midline long lines 2 person vs 1 person picc teams » login or register to post comments submitted by cheryl kelley, picc nurse, west virginia university hospi on december 5, 2006 - 19: 1 dilantin has nearly the same ph as draino and elocon. Trade balance: Regarding trade trends for the pharmaceutical industry, it is important to stress the fact that the active ingredients are the trade items. This is because for final pharmaceutical products trade is heavily obstructed by the health regulatory environments of a country and, the final stages of production not being complex, the general strategy followed by MNCs has been to develop the final stages - packaging and formulation - in the country in which the product is to be sold. Therefore, the bulk of trade flows is concentrated on active ingredients. However, this characteristic of the pharmaceutical trade may have been changing in Europe in recent years due to the increased harmonisation in the regulatory framework concerning the authorisation of pharmaceutical products.

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It is especially important to check with your doctor before combining ec-naprosyn with the following: ace inhibitors such as the blood-pressure drug zestril aspirin beta blockers such as the blood-pressure drug tenormin blood-thinning drugs such as coumadin furosemide lasix ; lithium eskalith, lithobid ; methotrexate naproxen sodium aleve, anaprox ; oral diabetes drugs such as diabinese and micronase phenytoin dikantin ; probenecid benemid ; sulfa drugs such as the antibiotics bactrim and septra ec-ec-naprosyn should not be used with antacids, h 2 blockers such as tagamet, or sucralfate carafate. Reference Books: 1. 2. 3. Bassett J, Denny R C, Jeffery G H, Mendharn J, Vogel's Textbook of Quantitative Inorganic Analysis, ELBS Longman, London. Grant- Statistical Quality control McGraw Hill ; . Beckett A H and Stenlake J B, Practical Pharmaceutical Chemistry Vol. I and II., The Anthlone Press of University of London. Connors K A, A Textbook of Pharmaceutical Analysis, Wiley Interscience, New York. Gary Christian- Analytical Chemistry John Wiley ; . Instrumental methods of Analysis- Ewing. Higuchi & Brochmann- Hanssen- Pharmaceutical Analysis- Interscience ; . Garrat- The quantitative analysis of Drug Toppan & Co. ; Vogel Text Book of Practical Organic Chemistry 5th edition and gemfibrozil. These foods include fruits, milk and yogurt, sweets, rice, pasta, beans, and starchy vegetables such as corn, potato, and green peas. It is especially important to check with your doctor before combining sporanox with any of the following: acid-blocking drugs such as tagamet, pepcid, and zantac alprazolam xanax ; atorvastatin lipitor ; blood-thinning drugs such as coumadin buspirone buspar ; busulfan myleran ; calcium channel blockers such as cardene, norvasc, and procardia carbamazepine tegretol ; clarithromycin biaxin ; cyclosporine sandimmune, neoral ; diazepam valium ; dofetilide tikosyn ; digoxin lanoxin ; docetaxel taxotere ; erythromycin e-mycin, ery-tab, and others ; indinavir crixivan ; isoniazid lovastatin mevacor ; methylprednisolone medrol ; midazolam versed ; nevirapine viramune ; oral diabetes medications such as diabeta, diabinese, glucotrol, micronase, orinase, and tolinase phenobarbital phenytoin dilantin ; pimozide orap ; quinidine quinidex ; rifabutin mycobutin ; rifampin rifadin, rimactane ; ritonavir norvir ; saquinavir invirase ; simvastatin zocor ; sirolimus rapamune ; tacrolimus prograf ; triazolam halcion ; trimetrexate neutrexin ; vinblastine velban ; special information if you are pregnant or breastfeeding the effects of sporanox during pregnancy have not been adequately studied.

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Family Interview with Moira Moira's family is made up of her father, mother and brother. Her parents are divorced and her mother has remarried. Moira lives with her mother, stepfather, brother and stepsister. Her brother and stepsister are both four years older than her. Moira was 12 years old and in grade 7 when diagnosed with leukemia. During the course of her chemotherapy treatment, her mother and stepfather separated. Moira is now 18 years old and is providing information about her health care experience. Salient Themes: V Support 1. Multidisciplinary support for patient and family h. social worker Learning Elements: Teaching to meet the needs and level of the audience Aiding patient transition back to school "Something I believe a social worker did do was to come and talk to my class at school. I very grateful for that. When kids hear about cancer there will be a lot of rumors. Even after the social worker came in to talk, there was the rumor that if you hugged me, you would get cancer. It was good that she could answer other people's questions. That way when I went back to school it was not as bad." Health Provider Discussion Questions: 1. What family centred care concepts were put into play in this family story? 2. As a professional, what experiences have you had in providing support to your patient in their school, work or community setting? Parent Discussion Questions: 1. What type of support did your teen receive from health care professionals in their school, work or community setting? How was it beneficial? 2. What other places would your teen have benefited a health professional's support?, because dilantin albumin.

About This Brief Issue 2006 Judge David L. Bazelon Center for Mental Health Law, Washington D.C. Reproduction of this issue brief all or in part is hereby authorized for non-commercial advocacy or educationalpurposes, with full attribution to the Bazelon Center for Mental Health Law. The brief was written by Chris Koyanagi, the Bazelon Center's policy director, with assistance by Katy Blasingame, and was edited and designed by publications director Lee Carty. Its development, production and distribution were funded by the JEHT Foundation, with additional support provided through the Bazelon Center's general program by the John D. and Catherine T. MacArthur Foundation. The Bazelon Center.
229. Bradford, H.F.: Glutamate, GABA and epilepsy. Prog Neurobiol 47, 477-511 1995 ; 230. Chapman, A.G.: Glutamate and epilepsy. J Nutr 130 Suppl 4S, 1043S-1045S 2000 ; 231. Holland, K.D., A.C. McKeon, D.J. Canney, D.F. Covey & J.A. Ferrendelli: Relative anticonvulsant effects of GABAmimetic and GABA modulatory agents. Epilepsia 33, 981-986 1992 ; 232. Balme, R.H.: Early medicinal use of bromides Sir Charles Locock ; . J R Coll Physicians Lond 10, 205-208 1976 ; 233. Joynt, R.J.: The use of bromides for epilepsy. J Dis Child 128, 362-363 1974 ; 234. Friedlander, W.J.: Who was "the father of bromide treatment of epilepsy?" Arch Neurol 43, 505-507 1986 ; 235. White, H.S.: Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. Epilepsia 38 Suppl 1, S9-S17 1997 ; 236. Avanzini, G.: Animal models relevant to human epilepsies. Ital J Neurol Sci 16, 5-8 1995 ; 237. Deyn, P.P.: Animal models of focal epilepsy. Acta Neurol Belg 99, 222-225 1999 ; 238. Merritt, H.H. & T.J. Putnam: Sodium diphenyl hydantoinate in the treatment of convulsive disorders. JAMA 111, 1068-1073 1938 ; 239. Merritt, H.H. & T.J. Putnam: A new series of anticonvulsant drugs tested by experiments on animals. Arch Neurol Psych 39, 1003-1015 1938 ; 240. Merritt, H.H. & T.J. Putnam: Landmark article Sept 17, 1938: Sodium diphenyl hydantoinate in the treatment of convulsive disorders. By H. Houston Merritt & Tracy J. Putnam. JAMA 251, 1062-1067 1984 ; 241. Friedlander, W.J.: Putnam, Merritt, and the discovery of Dilantin. Epilepsia 27 Suppl 3, S1-S20 1986 ; 242. Goldensohn, E.S.: Merritt-Putnam: the legacy. Epilepsia 33 Suppl 4, S3-S5 1992 ; 243. Glazko, A.J.: Discovery of phenytoin. Ther Drug Monit 8, 490-497 1986 ; 244. Swinyard, E.A.: Experimental models of epilepsy. A manual for the laboratory worker. Raven Press, New York, NY 1972 ; 245. White, H.S., M. Johnson, H.H. Wolf & H.J. Kupferberg: The early identification of anticonvulsant activity: role of the maximal electroshock and subcutaneous pentylenetetrazol seizure models. Ital J Neurol Sci 16, 73-77 1995 ; 246. Matagne, A. & H. Klitgaard: Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man. Epilepsy Res 31, 59-71 1998 ; 247. Lscher, W.: Animal models of intractable epilepsy. Prog Neurobiol 53, 239-258 1997 ; 248. Della Paschoa, O.E., M.R. Kruk, R. Hamstra, R.A. Voskuyl & M. Danhof: Seizure patterns in kindling and cortical stimulation models of experimental epilepsy. Brain Res 770, 221-227 1997 ; 249. Shandra, A.A., A.M. Mazarati, L.S. Godlevsky & R.S. Vastyanov: Chemical kindling: implications for antiepileptic drugs--sensitive and resistant epilepsy models. Epilepsia 37, 269-274 1996 ; 250. Velisek, L., J. Veliskova & S.L. Moshe: Developmental seizure models. Ital J Neurol Sci 16, 127133 1995 ; 251. Fariello, R.G.: Critical review of the animal models of generalized epilepsies. Ital J Neurol Sci 16, 69-72 1995. Personality and Post-Traumatic Symptomatology in Battered Women Bguena, M.J., Daz, A., Belea, A., Roldn, C., and Villarroya, E. Faculty of Psychology, Department of Personality, Assessment and Psychological Treatments, University of Valencia, Spain This research compares the results obtained in two groups: the first consist of 85 women age range 18-60, M : 36, 87, SD : 8, 96 ; with record of physical violence that had denounced their couple before the police; the second consist of 139 women without record of violence age range 18-41, M : 41, 80 and SD : 8, 96 ; The women fulfilled the following instruments: i ; The SVEAD Pelechano, 1998 ; which assess life events unrelated with domestic violence during the last ten years; ii ; The Impact of Event Scale Horowitz, Wilner and Alvarez, 1979 ; in the revised version EIE-R ; of Weiss 1996 ; which tapped the three groups of symptoms that identify the post-traumatic stress disorder intrusive, advoidance and hyperarousal symptoms iii ; The Questionnaire Patient QP ; of PRIME-MD Spitzer et al., 1994 ; , particularly the first 15 items relatives to physical symptoms; iv ; The Eysenck Personality Questionnaire Revised S.B.G. Eysenck, H.J. Eysenck and Barret, 1985 ; , specifically the extraversion and neuroticism scales; v ; The COPE brief Carver, Scheier and Weintraub, 1989 ; that in a previous factorial analysis with a Spanish sample Bguena et al., 2002 ; groups the coping strategies in two factors: COPE 1 active coping, planning, acceptance, positive reframing, use of humor, use of emotional support ; and COPE II denial, behavioral disengagement, self-distraction, alcohol drug use, religion, venting ; . Are presented the results related to internal consistency Cronbach's alpha ; , bivariated and multivariated analysis discriminant ; . The last show that the best variables discriminating battered and non-battered women are the number of life events unrelated with domestic violence, the hyperarousal symptoms, and neuroticism. These variables classified correctly the 81, 3% of the women 78, 8% and 82, 7% for battered and non battered women respectively ; . 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