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Greater extent of Type A "stylistics" observed in diuretic- versus beta-blockertreated patients appeared to be due as much to an increase in Type A-related attributes among individuals receiving diuretics as to a decrease in these characteristics among those administered betablockers. Importantly, this study indicated no effect of beta-blockers on stylistics reflecting hostility and competition, two components of the Type A "syndrome" thought to be particularly pathogenic 33 ; . The second patient investigation 32 ; was a retrospective study of individuals with heart disease and involved 65 patients receiving beta-blockers and 23 receiving other medication; however, there was only a marginally significant difference in Type A rating between groups, with a preponderance of individuals 81 of 88 ; categorized as Type A, regardless of treatment. In the absence of behavioral investigations involving out-of-laboratory assessments of chronically treated patients, it is difficult to determine whether the modest effects reported in the above-referenced patient studies generalize to spontaneous i.e., naturally occurring ; behavior of the type observed among monkeys in the current experiment. It is also not possible to REFERENCES and gemfibrozil.

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INTRODUCTION The need for better cancer treatment is evident. In the developed world, approximately one in three persons contracts cancer and around one in four of these dies from the disease. The worldwide incidence of cancer is predicted to double from 10 to 20 million over the next two decades and the death rate will increase from 6 to 10 million. Advances in treatment with surgery, radiotherapy and chemotherapy have had a limited impact on mortality. Cures can be achieved in childhood cancers, testicular cancer and lymphoma, and improvements in survival rates have been made as a result of the adjuvant drug treatment of breast and colorectal cancer. However, the majority of human cancers are difficult to treat, especially in their advanced, metastatic forms. The need for new and effective forms of systemic therapy is pressing and the discovery of novel, mechanismbased agents directed against the molecular pathology of cancer is of enormous potential[1]. It has been known for many years that cancer has a genetic component and it is clear that there is a multistage progression to malignancy. The application of modern molecular techniques to study cancer over the last 2 decades has led to the identification of 4 major groups of genes which are involved in tumourigenesis oncogenes, tumour suppressor TS ; , cell cycle control CCC ; and mismatch repair MMR ; . Cellular oncogenes proto-oncogenes ; encode proteins, which are important in the control of cell proliferation, differentiation, cell cycle control and apoptosis. Mutations in these genes act dominantly and lead to a gain of function. In contrast, TS genes inhibit!
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