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RT-09. RESULTS OF WHOLE BRAIN RADIATION THERAPY FOR PATIENTS WITH BRAIN METASTASES FROM EXTENSIVE STAGE SMALL CELL LUNG CANCER Aimee L. Quan, 1 Timothy J. Campbell, Glen H.J. Stevens, Shih-Yuan Lee, 2 Thomas W. Rice, 3 David J. Adelstein, 4 and John H. Suh2; 1 Department of Radiation Oncology, 2Brain Tumor Institute, 3Department of Thoracic Surgery, 4Department of Medical Oncology, Brain Tumor Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA Purpose: This study was conducted to evaluate the results of whole brain radiation WBRT ; for patients with brain metastases from extensive stage small cell lung cancer SCLC ; . Materials and Methods: A retrospective review of extensive stage SCLC patients with brain metastases treated with WBRT from January 1986 to July 2002 was performed. Patients who underwent prior surgery, stereotactic radiosurgery, or WBRT were excluded from this study. After excluding these patients, 93 patients median age 65 ; were available for analysis. Various prognostic factors were evaluated to determine the factors that influenced survival and radiographic response rate. Survival was measured from the initial date of diagnosis of brain metastases. Results: The overall median survival was 4.6 months m ; , with a 1-year survival of 13%. On univariate analysis, the factors that were found to significantly influence survival were KPS 70 vs. 70, P 0.039 ; and the time interval from initial diagnosis of the primary tumor to the development of brain metastases 3 m vs. 3 m, P 0.039 ; . On multivariate analysis, median survival was found to be significantly improved for patients whose lung primary was under control 9.2 m vs. 3.8 m, P 0.017 ; . In addition, a time interval from initial diagnosis of the primary tumor to the development of brain metastases of 3 m was also found on multivariate analysis to result in an improvement in median survival 5.8 m vs. 3.5 m, P 0.0095 ; . For the 48 patients who had radiographic follow-up median 2.6 m, range 0.325.3 m ; , 12 patients 25% ; had an initial complete response, and 14 29% ; had a partial or minimal response. Conclusions: Patients with brain metastases from extensive stage SCLC have a poor survival despite the use of WBRT. Further studies are needed to improve on these results. to 86 years median, 61 ; . The most common tumor was nonsmall-cell lung cancer. Median baseline KPS was 90, Fact-BR 132. The most common location of tumor was the frontal and or parietal lobes. Median cross-sectional tumor diameter was 2.5 cm range 15 ; . Implanted balloon sizes were 2 cm 30 patients ; , 3 cm 16 ; , and 4 cm 5 ; More than 1 implant was attempted in 3 patients. The median fluid volume was 5 ml. There were no complications resulting directly from balloon implantation, and all balloons were left inflated after implantation. Median radiation dose delivered to 10 mm from the balloon surface was 60 Gy 5664 the median dwell time was 114 hours 93162 ; . Patients were hospitalized 4 to 7 days median, 5 ; for brachytherapy. The device was explanted in all but 6 patients. Serious adverse events considered treatment-related include radiation necrosis 4 ; , CSF leak 1 ; , hydrocephalus 1 ; , and seizure 1 ; . Discussion: Our preliminary results indicate that GliaSite implantation and brachytherapy is well tolerated in brain metastasis patients, and there are few acute device-related adverse events. 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Undergraduate: 1967-1971 University of North Carolina Chapel Hill, North Carolina B.A. Degree; Chemistry 1974-1978 The Medical University of South Carolina Charleston, South Carolina M.D. Degree 1978-1979 Internship - Internal Medicine Department of Medicine The Medical University of South Carolina Charleston, South Carolina Residency - Internal Medicine Department of Medicine The Medical University of South Carolina Charleston, South Carolina Fellowship - Department of Medicine Division of Allergy and Clinical Immunology The Johns Hopkins University School of Medicine Baltimore, Maryland.

Drug Name doxepin hcl [CARE] DOXIL [INJ] doxorubicin hcl [INJ] doxycycline hyclate doxycycline hyclate, monohydrate doxy-lemmon drihist sr [CARE] DRITHO-SCALP drixomed droperidol [INJ] DROXIA drysec [CARE] DRYSOL, DAB-O-MATIC D-TAB d-tann DTIC-DOME IV [G][INJ] DUAC DUET DHA EC STUARTNATAL, DHA STUARTNATAL DUETACT duomax duotan pd [CARE] DURABAC, FORTE DURACLON [INJ] duradryl [CARE] DURAGESIC adh. patch 12 mcg DURAGESIC adh. patch 25 mcg, 50 mcg, 75 mcg, 100 mcg [G] DURAHIST, D, PE [CARE] DURAMORPH [G][INJ] DURAPHEN 1000 DURAPHEN II DURATAN PE [CARE] DURATUSS, A, GP, PE DURICEF [G] DYAZIDE [G] dyflex-g dy-g liquid dygase dylix DYNACIN [G] DYNACIRC CR dynahist er [CARE] Tier 1 4 1 Restrictions. NEW YORK STATE DEPARTMENT OF HEALTH 09 14 2007 LIST OF MEDICAID REIMBURSABLE DRUGS PRICING ERRORS ARE NOT REIMBURSABLE PRICES EFFECTIVE 09 14 2007 MRA COST -5.92998 5.92998 0.69660 0.73386 -0.64380 0.31770 0.54240 -1.95750 3.25500 3.44114 -0.02529 0.00218 0.00458 0.00138 -0.19200 0.07731 0.07270 0.66800 COST ALTERNATE -FORMULARY DESCRIPTION 30-2 MG TABLET DUETACT 30-4 MG TABLET DUONEB 2.5-0.5 MG 3 ML SOLN DUONEB 2.5-0.5 MG 3 ML SOLN DUONEB 2.5-0.5 MG 3 ML SOLN DURACLON 0.1 MG ML VIAL DURACLON 500 MCG ML VIAL DURICEF 250 MG 5 ML ORAL SU DURICEF 250 MG 5 ML ORAL SU DURICEF 500 MG 5 ML ORAL SU 500 MG 5 ML ORAL SU DYAZIDE 37.5 25 CAPSULE DYAZIDE 37.5 25 CAPSULE DYGASE CAPSULE DYNACIN 100 MG CAPSULE DYNACIN 100 MG CAPSULE DYNACIN 100 MG TABLET DYNACIN 100 MG TABLET DYNACIN 50 MG TABLET DYNACIN 75 MG CAPSULE 75 MG CAPSULE DYNACIN 75 MG TABLET DYNACIN 75 MG TABLET DYNACIRC CR 10 MG TABLET SA DYNACIRC CR 5 MG TABLET SA DYNACIRC 5 MG CAPSULE DYPHYLLIN GG TABLET DYPHYLLINE GG ELIXIR DYPHYLLINE GG ELIXIR DYPHYLLINE-GG ELIXIR ELIXIR D5-1 2NS KCL 20 MEQ L IV SO D5-1 2NS KCL 20 MEQ L IV SO D5%-1 2NS SOLN EXCEL CONT D5W KCL 40 MEQ L IV SOLUTIO E.E.S. 200 MG 5 ML GRANULES E.E.S. 200 MG 5 ML GRANULES E.E.S. 200 MG 5 ML SUSPENSI E.E.S. 200 MG 5 ML SUSPENSI E.E.S. 400 FILMTAB 400 FILMTAB E.E.S. 400 MG 5 ML SUSPENSI E.E.S. 400 MG 5 ML SUSPENSI EC-NAPROSYN 500 MG TABLET E ECONAZOLE NITRATE 1% CREAM PA CD -0 0 A A A -8 8 0 0 -8 8 0 0 -0 0 0 0 0 -0 0 0 8 0.
That the accused is not found guilty of unprofessional conduct during the period of suspension. Also ordered to attend rehabilitation and report to the Health Committee monthly and cefdinir. SHAUN O'KEEFFE, GILL HARVEY, MICHAEL LYE Department of Geriatric Medicine, Royal Liverpool University Hospital, PO Box 147, Prescot Street Liverpool L69 3BX, UK Address correspondence to: M. Lye. Fax + 44 ; 151 706 4064. E-mail: m.lye liverpool.ac.

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