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Note that the 2001 numbers are significantly higher than the other years in most categories; that is because FDA issued nearly twice as many letters in 2001. Why is not clear. It may reflect a shift in enforcement emphasis; the FDA issued several letters relating to promotion at medical conferences in 2001, but very few in the other years. The change may reflect the change of administration in Washington D.C. and a resulting shift in resources and priorities. The sharp decrease between 2001 and 2002 may also reflect a decrease in false advertising by drug marketers, however, the year to year changes among 2002-2005 are nowhere near as great, so it is hard to imagine that a change in marketing practices represents the whole shift between those or any other years, for instance, hhydrocodone and acetaminophen.
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26 August The Miami Herald reported that Chinese officials tried to deflect possible criticism of their decision not to publicize their discovery of a deadly bird flu strain in pigs last year, saying the animals weren't sick and the cases were not a threat to humans. The pigs carried a flu strain - H5N1 - found in ducks rather than a new version that might be more dangerous to people, said Jia Youling, China's chief veterinary official. He said the pigs were quickly isolated. Jia insisted Beijing had no obligation to tell international agencies about it. The World Health Organization has appealed for more information following China's disclosure that it found two strains of avian flu in pigs. Pigs are genetically similar to humans and experts worry that a version of bird flu that can infect pigs might spread to people more easily. China's government insisted earlier that the discovery of the virus in pigs had been reported in scientific journals. It says it informed WHO of the results of a later study of 1.5 million pigs and poultry that found no sign of the virus. View Article registration required and levothroid and hydrocodone, because norco hydrocodone.

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17.3; table 7 ; of developing prostate cancer over a period of 615 years. No CYP3A4 * 1B homozygotes were observed in this study group; however, heterozygotes occurred in excess in the case group Hardy-Weinberg 2 4.8, p 0.02 ; . In a second cohort study of 400 men with benign prostatic hyperplasia, for 21 men who developed prostate cancer, the relative risk associated with inheritance of CYP3A4 * 1B was 2.7 95 percent CI: 0.77, 7.66 ; table 7 ; 83 ; . study of Caucasians n 816 ; and African Americans n 76 ; , in which a family-based case-control design was used sibling pairs: 440 cases and 480 controls ; , investigated the CYP3A4 * 1B and CYP3A5 * 1 genotypes and the CYP3A4 * 1B CYP3A5 * 3 haplotype for associations with prostate cancer risk and tumor aggressivity 23 ; . Consistent with findings from previous studies, those for comparison of CYP3A4 * 1B frequencies between prostate cancer cases and controls showed no simple associations OR 0.9, 95 percent CI: 0.6, 1.4 for Caucasians and OR 1.0, 95 percent CI: 0.4, 2.5 for African Americans ; . However, when stratified by aggressivity, results indicated that CYP3A4 * 1B was a risk factor for more aggressive prostate cancer in Caucasians OR 1.9, 95 percent CI: 1.0, 3.6 ; but not African Americans OR 0.5, 95 percent CI: 0.2, 1.4 ; . The CYP3A5 * 1 variant was inversely associated with prostate cancer in Caucasians with less aggressive disease OR 0.4, 95 percent CI: 0.2, 0.8 ; but not in African Americans OR 0.9, 95 percent CI: 0.1, 8.7 ; . The CYP3A4 * 1B CYP3A5 * 3 haplotype was positively associated with prostate cancer when data from African Americans and Caucasians were combined OR 2.9, 95 percent CI: 1.4, 6.2 ; . Overall, the data from the five prostate cancer studies described above do not provide convincing support for a direct role of CYP3A4 * 1B in prostate carcinogenesis 25, 26, 38, ; . However, the apparent association of CYP3A4 * 1B with other factors such as age and clinical stages of disease will likely make this role difficult to define. In the studies from Scotland, CYP3A4 * 1B appears to play a role in high-risk benign prostatic hyperplasia ; patients. Two studies of Caucasians suggest an association with advanced disease only, whereas findings from studies of African Americans are inconsistent. A major gap is the dearth of robust, but basic case-control studies; future studies might consider gene-environment and gene-gene interactions in seeking an association between prostate cancer and CYP3A4 polymorphisms.
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Reagents--DHT Sigma ; was dissolved in highly refined ethanol Gold Shield Chemical Co., Hayward, CA ; at 1 mM concentration as stock solution. Serial 10-fold dilutions were made from this stock solution to prepare DHT solutions of different concentrations, which were diluted 1: 1000 to make the final concentrations of DHT needed to treat cells. BI was a gift from Zeneca Pharmaceuticals Plankstadt, Germany ; and was dissolved in 100% ethanol at a concentration of 10 mM and stored at 20 C. Cycloheximide Sigma ; was prepared as a 10 mg ml solution in ethanol. Human Prostate Cell Cultures--Primary cultures of normal human prostate epithelial cells PrEC ; were purchased from Clonetics Walkersville, MD ; and cultured in serum-free prostate epithelial cell growth medium following the vendor's directions. The prostate carcinoma cell lines LNCaP-FGC LNCaP ; , DU145, and PC-3 were obtained from the American Type Culture Collection Manassas, VA ; . LNCaP is an androgen-dependent prostate cancer cell line expressing AR and prostate-specific antigen and was maintained in RPMI 1640 medium supplemented with 10% fetal bovine serum FBS ; from Invitrogen. 22Rv1 is an AR-positive prostate cancer cell line derived from a relapsed xenograft, kindly provided by Dr. Thomas G. Pretlow and Dr. James W. Jacobberger 26 ; , and was cultured in RPMI 1640 medium supplemented with 10% FBS. Although its growth no longer requires androgen, the 22Rv1 cell line is still androgen-responsive. DU145 and PC-3 are androgen-independent prostate cancer cell lines that do not, because hydrocodone compound. First Do No Harm" is a cornerstone of modern medicine. "I think the practice of combining acetaminophen Tylenol is one popular brand ; and an opiate, such as hydrocodone bitartrate, together as a single drug as Vicodin does ; defies logic, if not common sense." Acetaminophen is a "potent dose-dependent poison for the liver; simply stated, if you take too much, your liver dies." Acetaminophen overdose is the "leading cause of acute liver failure in the United States today." On the other hand, opiates, such as hydrocodone bitartrate and codeine, while safe for the liver, are highly addictive. "Vicodin is currently the most popular prescription drug in the United States." Some patients become addicted to the opiate component of Vicodin and consume increasing amounts of acetaminophen, "ultimately leading to acute liver failure." "With overwhelming liver injury from acetaminophen, what follows is a particularly grisly death punctuated by bleeding, confusion, coma and, for still largely unclear reasons, brain swelling, damage and death." "Patients typically take too much acetaminophen for fever or pain over several days, not realizing the potential for liver damage." "Many are unaware that acetaminophen is contained in dozens of over-the-counter cold and flu preparations." "This situation is particularly tragic in young children accidentally overdosed with acetaminophen, typically in the setting of a flu-like illness, by well-intentioned but misinformed parents." Acetaminophen packaging should have better warning labels, and should not be sold in 1, 000 pill mega-bottles. Acetaminophen-opiate combinations [like Vicodin] should be removed from the market. "The prescription rules in California have made it far easier for physicians to prescribe an acetaminophen-opiate combination, such as Vicodin, than a pure opiate, such as codeine, although the former is far more dangerous." The FDA banned Ephedra, which "contrasts with its puzzling, relatively meager efforts to prevent acetaminophen hepatotoxicity, which kills far more Americans each year than Ephedra and hyzaar.
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