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The speakers indicated that FDA or Congress may consider past Agency actions as precedents upon which to guide future administrative actions or lawmaking efforts: "Either administrative discretion or legislation has the ability to draw on regulatory precedents and policies to create a system capable of yielding a biologic that is comparable to the originator biologic and whose approval likely is based primarily on a single clinical trial." This observation was drawn from an evolutionary assessment of FDA's previous approval decisions concerning biologics. Because active ingredients in biologics are larger and more complex than those in drugs derived through chemical processes, it is scientifically challenging to determine the "sameness" of biologically active products. Prior to 1996, CBER defined a biologic by its manufacturing process, according to Sasinowski and Karst. This position had been validated in the finding in 1993 that two different manufacturing processes for a specific biologic Activase ; had and levoxyl, because levaquin levofloxacin. Aranesp $1, 371, 105, 482.21 Procrit 1, 296, 168, Lovenox 1, 276, 041, Neulasta 860, 663, 090.97 Remicade 749, 934, 062.40 Zofran 743, 332, 856.45 Rituxan 706, 619, 953.83 Levaauin 647, 254, 779.46 Zocor 574, 976, 949.71 Revlimid 532, 689, 250.00 Zosyn 519, 206, 339.73 Avastin 490, 261, 750.00 Neupogen 442, 497, 359.00 Propofol 419, 219, 749.37 Eloxatin 386, 784, 608.90 Protonix IV 376, 123, 056.00 Diprivan 375, 405, 650.36 Integrilin 350, 368, 803.15 Herceptin 325, 936, 394.66 Advair Diskus 317, 747, 010.41 Omnipaque 310, 327, 519.15 Protonix 300, 702, 365.57 Zyvox Ceftriaxone 296, 310, 137.46 Taxotere 286, 624, 362.00 Ultane 284, 418, 649.68 Cancidas 275, 150, 690.26 Thrombin-JMI 254, 922, 999.49 Sodium Chloride 252, 097, 230.90 Seroquel 234, 842, 481.60 Primaxin 234, 108, 900.65 Angiomax 230, 247, 952.00 Gamunex 221, 287, 666.50 Carimune NF Nanofiltered 219, 074, 629.16 Gemzar 214, 768, 035.96 Zometa 213, 505, 675.64 Erbitux 211, 631, 520.00 Prevacid 201, 534, 906.98 Morphine Sulfate 199, 872, 998.68 Risperdal 191, 137, 629.92 Epogen 184, 952, 297.76 Zyprexa 182, 400, 930.17 Plavix 175, 517, 586.70 Camptosar 172, 463, 877.90 Nexium 170, 975, 234.30 Aciphex 165, 918, 818.43 Lipitor 165, 139, 808.10 Lupron Depot 162, 729, 021.12 Maxipime 160, 256, 077.93 ReoPro 154, 802, 615.01 Suprane Adenoscan 149, 479, 540.05 Trasylol 148, 814, 993.44 Synagis 144, 522, 451.59 Vancomycin HCl 142, 330, 455.16 Paclitaxel 142, 287, 250.92 Carboplatin 141, 079, 017.49 Optiray 320 Normal Saline Flush 138, 985, 420.67 Zoladex 127, 558, 327.93 Kytril 127, 152, 953.47 Zemuron 126, 545, 924.57 Combivent 125, 968, 343.44 Cefazolin 125, 239, 581.82 Sodium 124, 187, 157.00 Ambisome 122, 871, 828.57 Fentanyl Azithromycin 122, 427, 236.01 Isovue-300 120, 810, 525.62.
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THE LEARNING STYLES OF ANESTHESIOLOGISTS AUTHORS: I. T. Cohen AFFILIATION: Children's National Medical Center, Washington, DC. INTRODUCTION: Do anesthesiologists, as a group, have a learning style profile? Learning styles and strategies are the strengths and preferences that form our educational experience. Numerous investigators including Myers-Briggs, Koch, Strenberg and Felder have examined these characteristics. Myers and Briggs observed that their indicators often correlated with academic and professional pursuits. In this study, the learning styles and strategies of anesthesiologists were assessed to determine if any trends exist in our medical specialty. Method: At the 2002 Spring Meeting of the Society for Education in Anesthesia, attendees were surveyed using the Index of Learning Style Questionnaire1. The questionnaire, initially designed to assess engineering students, consists of forty-four questions and scores the respondent in four dichotomous areas: Active vs. Reflective, Sensory vs. Intuitive, Visual vs. Verbal, and Sequential vs. Global. Individual scores range along a continuum 0 to 11 ; for each area. A score of 4-7 signifies an essentially balanced condition, 2-3 and 8-9 reflects a moderate preference towards one pole, 0-1 and 10-11 reflects a strong preference towards one pole. The results were assessed using descriptive statistics and chi square analysis. RESULTS: Of the 139 registered attendees, 59 42.4% ; returned the questionnaire. Three questionnaires were incomplete and were not included in the group data. A review of the scores showed a strong polarization towards Reflective and Visual learning styles and a more balanced result in the Sensory-Intuitive and Sequential-Global areas. 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Abstract: OBJECTIVE: A diverse diet is recommended in many dietary guidelines. However, because there are no unified standards for measurement methods, objective comparisons across different populations or time points is difficult. This report proposes a new dietary diversity index based on quantitative distribution of consumed foods to allow objective measurement of dietary diversity. METHODS: A Quantitative Index for Dietary Diversity QUANTIDD ; is proposed: QUANTIDD 1-summation operatorjn prop[j]2 ; 1-1 n ; , where prop j ; is the proportion of food group s ; j that contributes to total energy or nutrient intake, n is the number of food groups, and j 1, 2, ., n. The numerator is the probability that the two foods taken out of an aggregation of consumed foods belong to different food groups. The denominator is its maximum value. The index ranges from 0 to 1. using the officially released average data from the National Nutrition Survey in Japan from 1957 to 2000, we investigated annual changes in the QUANTIDD. We also investigated the distribution of the index by using individual data from the National Nutrition Survey in Japan in 1996. RESULTS: The QUANTIDD increased from the 1960s to the 1970s. This was the era of rapid economic growth in Japan, during which the dietary habits of the Japanese underwent rapid changes. The distribution of the QUANTIDD was skewed to the left, but logit-transformation decreased this asymmetry and made it similar to a normal distribution. CONCLUSION: Because this index can measure dietary diversity objectively and is suitable for statistical handling, it is useful as a method to compare dietary patterns across different populations or time points. 6, for example, levaquon leva pak.

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Levofloxacin exerts its antibacterial actions by preventing the synthesis of bacterial DNA through inhibition of the enzyme DNA gyrase. Levofloxacin has a wide range of activity against gram-negative and gram-positive bacteria, including H. influenzae, M. catarrhalis, S. pneumoniae, S. aureus, H. parainfluenzae, S. pyogenes, E. coli, E. cloacae, C. pneumoniae, M. pneumoniae, L. pneumophila, K. pneumoniae, P. aeruginosa, E. faecalis, P. mirabilis. 24 to 38% is serum protein bound. 87% is excreted unchanged in the urine. The remaining is metabolized to inactive metabolites. Serum half-life is 6-8 hours. Peak serum levels are reached in 1-2 hours after an oral dose. Interactions Antacids, sucralfate and iron products reduce the absorption of levofloxacin. Nonsteroidal anti-inflammatory agents may lower seizure thresholds and predispose patients to convulsive seizures when taking levofloxacin. Other quinolones have been shown to have mild drug interactions with warfarin and theophylline therefore appropriate monitoring is recommended. Disturbances of blood glucose has occurred in patients taking quinolones and antidiabetic agents. Precautions Contraindicated in patients with a hypersensitivity to quinolones. Use with caution in patients with known or suspected CNS disorders, especially those which predispose to seizures. Convulsions, increased intracranial pressure and psychosis have been reported in patients receiving quinolones. Quinolones have been reported to cause serious and sometimes fatal hypersensitivity reactions - therapy should be discontinued at the first sign of a skin rash or other allergic reaction. Quinolones have been shown to cause ruptures of the shoulder, hand, and Achilles tendons. Lveaquin should be discontinued if the patient experiences pain, inflammation or rupture of a tendon. Use with caution in patients with impaired liver function. Periodic liver function tests should be performed during prolonged therapy. Use with caution in nursing mothers. Not indicated for treatment of infections in patients under the age of 18 years. Pregnancy Category C. Adverse Effects Nausea 7% ; , diarrhea 5% ; , headache 5% ; , constipation 3% ; , and taste perversion 1% ; . Patient Consultation Store in a cool, dry place away from sunlight and children. If a dose is missed, take it as soon as possible. If it is closer to the time of your next dose than the dose you missed, skip the missed dose and return to your dosing schedule. Do not double doses. Contact a physician if the above side effects are severe or persistent. Discontinue use and contact a physician if a rash develops or you experience pain, inflammation, or rupture of a tendon. Finish medication unless otherwise instructed by a physician. Drink a full glass of water 240 ml ; after each dose. May be taken without regards to meals. Do not take antacids, sucralfate, metal cations such as iron, and multi-vitamins containing zinc within 2 hours of each dose. Avoid prolonged exposure of skin to sunlight. Continually monitor blood glucose if taking an antidiabetic medications and stop Leavquin if a hypoglycemic reaction occurs and contact a physician. Today best offers for levaquin best levaquin in web for you - levaquin general save money - best levaquin many discounts levaquin trusted and approved resource guaranted low price and medroxyprogesterone.

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Fatty liver may lead to insulin resistance and diabetes, and may even lessen the anti-hiv effects of any drug combination you take, for example, levaquin interaction.

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