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Lamotrigine
Nature-throid 180 mg tablet * . 108 nature-throid 30 mg tablet * . 108 nature-throid 60 mg tablet * . 108 NATURETIN-5 TABLET * . 61 NAVANE 10 MG CAPSULE * . 65 NAVANE 2 MG CAPSULE * . 65 NAVANE 20 MG CAPSULE * . 65 NAVANE 5 MG CAPSULE * . 65 nava-sc 4% cream * . 93 ND-GESIC 300 MG TABLET * . 153 ND-STAT 10 MG ML VIAL PA . 157 NEBCIN 1.2 GM VIAL PA . 18 NEBCIN 100 MG DEXTROSE 5% PA . 18 NEBCIN 40 MG ML VIAL PA . 18 NEBCIN 60 MG DEXTROSE 5% PA. 18 NEBCIN 80 MG DEXTROSE 5% PA. 18 NEBCIN PED 10 MG ML VIAL PA . 18 NEBUPENT 300 MG INHAL POWDER * QL . 28 necon 0.5 35-21 tablet * . 138 necon 1 35-28 tablet * . 138 necon 1 50-21 tablet * . 138 necon 10 11-21 tablet * . 138 necon 7 7-28 tablet * . 138 NEGGRAM 1 GM CAPLET * . 168 NEGGRAM 250 MG CAPLET * . 168 NEGGRAM 500 MG CAPLET * . 168 neo bacit poly eye ointment * . 147 neo bacit poly hc eye oint * . 145 neo poly dexamet eye oint * . 145 neo polymyxin dexameth drop * . 145 neo polymyxin hc ear soln * . 95 neocidin eye drops * . 147 NEOCIDIN EYE OINTMENT * . 147 neocin-pg eye drops * . 147 NEO-FRADIN 125 MG 5 ML SOLN * . 18 neofrin 2.5% eye drops * . 149 neomyci poly gram ophth sol * . 147 neomycin 500 mg tablet * . 18 neomycin poly hc eye drops * . 145 neoptic eye drops * . 147 NEORAL 100 MG GELATN CAPSULE * . 122 NEORAL 100 MG ML SOLUTION * . 122 NEORAL 25 MG GELATIN CAPSULE * . 122.
Conclusions: adolescents with bipolar depression appeared to respond to lamotrigine treatment, whether as adjunctive therapy or monotherapy, with decreases in depression , mania, and aggression.
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And if anyone had their depression treated with tegretol , dilantin, neurontin, depakote lamotrigine, or the.
Valproate [IV] Usual dose range 1000 to 2500 mg; serum concentration 350700 mol L ; OR Lamotriglne [IV] Usual dose range 50300 mg; serum concentration not useful ; OR Carbamazepine [IV] Usual dose range 600 to 1200 mg; serum concentration 17 50 mol L ; OR Lithium [V-I] Aim for serum concentration of 0.6 0.8 mmol L.
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Corresponding Author: Steven C. George, M.D., Ph.D. Department of Biomedical Engineering 3120 Natural Sciences II University of California, Irvine Irvine, California 92697-2715 Telephone: 949 ; 824-3941 Fax: 949 ; 824-2541 Email: scgeorge uci.
WISHA has adopted a PEL of an eight-hour TWA of 85 dBA for noise, which is designed to guard against unnecessary hearing damage. Values equal to or below these levels are considered acceptable for industrial noise exposure without the use of hearing protection. Maximum exposure level: Any exposure above the ceiling level mandates the use of hearing protection regardless of the exposure duration. For continuous noise, the ceiling level is anything above 115 dBA; and for impact impulse noise, the ceiling is at or above 140 dBA. 6.5 Noise Evaluation and Control Procedures and levothyroxine.
AED Carbamazepine 11.1 ; Phenobarbital 14.6 ; Phenytoin 8.5 ; Valproate 205 ; Lamltrigine 5.9 ; Topiramate 28.9.
| Lamotrigine tablets 100mgChildhood absence epilepsy is an autosomal dominant disorder with incomplete penetrance [see Figure 1]. The age of onset is 4 to years. These patients have normal development and a normal neurologic examination. The syndrome consists of classic absence seizures, which typically occur multiple times a day; 50% of patients also experience generalized tonic-clonic seizures. Childhood absence epilepsy responds well to ethosuximide, valproate, or lamotrigine. The prognosis is good, with spontaneous remission after 2 to 3 years in most patients.10 and lithobid.
Address for correspondence and reprint requests: Yasuhito Uezono, M.D., Ph.D., Department of Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan Phone: + 81-95-849-7047 Fax: + 81-95-849-7048 E-mail: uezonoy alpha.med.nagasaki-u.ac.jp.
58. Schapel GJ, Beran RG, Vajda FJE, et al. Double-blind, placebo controlled, crossover study of lamotrigine in treatment resistant partial seizures. J Neurol Neurosurg Psychiatry. 1993; 56: 448 Besag FMC, Wallace SJ, Dulac O, Alving J, Spencer SC, Hosking G. Lamotriginr for the treatment of epilepsy in childhood. J Pediatr. 1995; 127: 991997 Brodie MJ, Yuen AWC, 105 Study Group. Lamotigine substitution study: evidence for synergism with sodium valproate? Epilepsy Res. 1997; 26: 423 Brodie MJ, Richens A, Yuen AWC. Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. Lancet. 1995; 345: 476 Buchanan N. Lamotrigine: clinical experience in 93 patients with epilepsy. Acta Neurol Scand. 1995; 92: 28 Buchanan N. The efficacy of lamotrigine on seizure control in 34 children, adolescents, and young adults with intellectual and physical disability. Seizure. 1995; 4: 233236 Motte J, Trevathan E, Arvidsson JFV, et al. Lamot4igine for generalized seizures associated with the Lennox-Gastaut syndrome. N Engl J Med. 1997; 337: 18071812 Sander JWAS, Hart YM, Patsalos PN, Duncan JS, Shorvon SD. Lamotrigine and generalized seizures. Epilepsia. 1991; 32 suppl 1 ; : 59. Abstract 66. Reunanen M, Dam M, Yuen AWC. A randomised open multicentre comparative trial of lamotrigine and carbamazepine as monotherapy in patients with newly diagnosed or recurrent epilepsy. Epilepsy Res. 1996; 23: 149 Buchanan N. The use of lamotrigine in juvenile myoclonic epilepsy. Seizure. 1996; 5: 149 Timmings PL, Richens A. Efficacy of lamotrigine as monotherapy for juvenile myoclonic epilepsy: pilot study results. Epilepsia. 1993; 34 suppl 2 ; : 160. Abstract 69. Veggiotti P, Cieuta C, Rey E, Dulac O. Lamotrigine in infantile spasms. Lancet. 1994; 344: 13751376 Uldall P, Hansen FJ, Tonnby B. Lamotrigine in Rett's syndrome. Neuropediatrics. 1993; 24: 339 Ferrie CD, Robinson RO, Knott C, Panayiotopoulos CP. Lamotrigine as an add-on drug in typical absence seizures. Acta Neurol Scand. 1995; 91: 200 Guerrini R, Dravet C, Genton P, Belmonte A, Kaminska A, Dulac O. Lamotrigine and seizure aggravation in severe myoclonic epilepsy. Epilepsia. 1998; 39: 508 Uvebrant P, Bauziene R. Intractable epilepsy in children. The efficacy ` of lamotrigine treatment, including non-seizure-related benefits. Neuropediatrics. 1994; 25: 284 Battino D, Buti D, Croci D, et al. Lamotrigine in resistant childhood epilepsy. Neuropediatrics. 1993; 24: 332336 Buchanan N. Lamotrigine: clinical experience in 200 patients with epilepsy with follow-up to four years. Seizure. 1996; 5: 209 Schlumberger E, Chavez F, Palacios L, Rey E, Pajot N, Dulac O. Lamotrigine in treatment of 120 children with epilepsy. Epilepsia. 1994; 35: 359 Mims J, Penovich P, Ritter F, Frost MD. Treatment with high doses of lamotrigine in children and adolescents with refractory seizures. J Child Neurol. 1997; 12: 64 Donaldson JA, Glauser TA, Olberding LS. Lamotrigine adjunctive therapy in childhood epileptic encephalopathy the Lennox-Gastaut syndrome ; . Epilepsia. 1997; 38: 68 Farrell K, Connolly MB, Munn R, Peng S, MacWilliam LM. Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy. Pediatr Neurol. 1997; 16: 201205 Oller LFV, Russi A, Oller Daurella L. Lamotrigine in the LennoxGastaut syndrome. Epilepsia. 1991; 32: 58. Abstract 81. Timmings PL, Richens A. Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome. Eur Neurol. 1992; 32: 305307 Eriksson A-S, Nergrdh A, Hoppu K. The efficacy of lamotrigine in children and adolescents with refractory generalized epilepsy: a randomized, double-blind, crossover study. Epilepsia. 1998; 39: 495501 Dooley J, Camfield P, Gordon K, Camfield C, Wirrell E, Smith E. Lamotrigine-induced rash in children. Neurology. 1996; 46: 240 Brodie MJ. Tiagabine pharmacology in profile. Epilepsia. 1995; 36 suppl 6 ; : S7S9 85. Sachdeo RC, Leroy RF, Krauss GL, et al. Tiagabine therapy for complex partial seizures: a dose frequency study. Arch Neurol. 1997; 54: 595 Richens A, Chadwick DW, Duncan JS, et al. Adjunctive treatment of partial seizures with tiagabine: a placebo-controlled trial. Epilepsy Res. 1995; 21: 37 and lithium.
| Rebecca ephraim is a registered dietitian, certified clinical nutritionist and a nutrition reporter specializing in integrative medicine issues.
Safety of Intravitreal Voriconazole: Electroretinographic and Histopathologic Studies When voriconazole was used for systemic fungal infections through either oral or intravenous administration, adverse effects were observed, including transient visual disturbance, hepatotoxicity, and skin reactions. The most frequent side effect is transient visual disturbance, described as enhanced light perception, blurred vision, photophobia, or color vision changes. These visual events occurred in 23% to 35% of patients, 12 generally within 30 minutes of dosing, and most frequently during the first week of therapy. These events were usually mild and resolved within 30 minutes. Electroretinographic study has shown that retina is the site of these events, with decreased amplitude of ERG waveforms in human and dogs.31 Histologic examination showed no alterations in the retina or visual pathways in dogs as a result of voriconazole administration. No human histopathology has been found, and ocular examination has not detected any lesions.12 No potential mechanism of this visual disturbance has been described.14 It is possible that rats might experience similar early transient visual disturbance in our studies, but this would be very difficult to determine, since visual changes have to be tested subjectively. However, we did not observe any electroretinographic or histologic abnormalities 3 weeks after intravitreal voriconazole 25 g mL ; injection. Thus, our results confirm previous studies of systemic voriconazole that found that electroretinographic changes, if any, occur in early stages, are transient, do not last more than 3 weeks after voriconazole administration, and do not cause permanent damage to the retina. Pharmacokinetic studies showed that tissue concentration of voriconazole after systemic administration was highest in liver, followed by the retina.12 Based on this fact, we studied oral voriconazole penetration to human vitreous and aqueous humor to determine if systemic voriconazole can be used for treatment of fungal endophthalmitis. After two dosages of 400 mg oral voriconazole, vitreous and aqueous humor specimens of 14 patients were obtained from vitrectomy and analyzed with highperformance liquid chromatography. Intravitreal and intracameral concentrations of voriconazole were 0.81 0.31 g mL and 1.13 0.57 g mL, respectively, and were 38.1% and 53.0% of plasma concentration, respectively.32 Since the MIC90 of voriconazole for most of the yeast and molds is low, systemic voriconazole is a good choice for endogenous fungal endophthalmitis. For those systemic fungal infections known to be sensitive to voriconazole, oral or intravenous administration can be used to treat both the systemic infection and endophthalmitis. Supplementary intravitreal injection of the drug can be used if needed. For those fungi, such as Fusarium species, in which MIC is higher than the intraocular level achieved by systemic administration, intravitreal voriconazole injection is an excellent choice for treatment. Since and loxitane!
There is some evidence for the effectiveness of lamotrigine in central post-stroke pain and in the subgroup of hiv-related neuropathy.
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SSOV1 TCAM1 TCAM2 TCLB1 TCLB2 TCLZ1 TCLZ2 TLMT1 TLMT2 TOXC1 TOXC2 TOXC3 TPHB1 TPHB2 TSOV1 TTPR1 TTPR2 TTPR3 07.01.0 IMTZ1 TMTZ1 07.02.0 TALB1 07.03.0 CAMP1 CAMX1 CCEP1 CCHL1 CCLA1 CCLX1 ECFL1 ECHL1 EGEE1 EMUP1 ENSO3 IAMK1 IAMP1 IAUG1 SODIUM VALPROATE SYR 110ML CARBAMAZEPINE TAB CARBAMAZEPINE TAB CLOBAZAM TAB CLOBAZAM TAB CLONAZEPAM TAB CLONAZEPAM TAB LAMOTRIGINE TAB LAMOTRIGINE TAB OXCARBAZEPINE TAB OXCARBAZEPINE TAB OXCARBAZEPINE TAB PHENOBARBITONE SODIUM TAB PHENOBARBITONE SODIUM TAB SODIUM VALPROATE TAB TOPERAMATE TAB TOPERAMATE TAB TOPERAMATE TAB AMOEBICIDES METRONIDAZOLE I.V 100ML METRONIDAZOLE TAB ANTI HELMENTIC DRUGS ALBENDAZOLE TAB ANTI BACTERIAL DRUGS AMPICILLIN CAP AMOXYCILLIN CAP CEPHALEXIN CAP CHLORAMPHENICOL CAP AMPICILLIN WITH CLOXACILLIN CAP CLOXACILLIN CAP CIPROFLOXACIN EYE EAR DROPS CHLORAMPHENICOL APPLICAPS GENTAMICIN EYE EAR DROPS MUPIROCIN OINT 5GM NEOSPORIN SKIN OINT 15GM AMIKACIN SULPHATE INJ AMPICILLIN SODIUM INJ. AMOXYCILLIN + CLAVULANIC ACID INJ 500 MG 500 MG 1.20 GM 250 MG 5 ML 250 MG 5 ML 2%W W and loxapine.
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Despite the fact that interventions and effective approaches to controlling pain have been well documented, health care professionals need to be diligent in the management of pain at the end of life. Unrelieved pain for the patient at the end of life is dehumanizing and an ethical issue.25 Although there are several barriers to effective pain management at the end of life, these can be avoided. Needed medications should not be withheld because of a fear that the patient may become an addict or that death may be induced by respiratory depression. Documented studies validate the exaggerated fear of addiction, particularly in patients at the end of life. Also, the likelihood of inducing respiratory depression in a patient with pain is minimal, but the ethical principle of the "double effect" allows for the administration of opioids to control pain even though the dying process may be hastened. Nearly all pain in patients who are dying can be controlled if current management strategies are utilized. Therefore, the inability to control pain at the end of life is not a valid argument for advocates of physician-assisted suicide and euthanasia. Physicians play a critical role in effective pain management at the end of life; incorporating these strategies for pain management in clinical practice can allow their patients to die in comfort and with dignity.5, because lamoyrigine bipolar depression.
B. Oral Presentations Biotechnology i Microbiology, Biochemistry, Fermentation and Gene Engineeringj Physical, Organic and Analytical Chemistry Pharmacology, Pathology and Immunology Food Science and Nutrition Process Engineering and lyrica.
The AstraZeneca Psychiatric Pharmacy Practice Award is presented at the CPNP Annual Meeting and is given to a practicing pharmacist who presents a case study on a challenging, rewarding, or otherwise noteworthy patient management experience in mental health or psychopharmacology. The case study should cover some aspect of pharmaceutical care related to schizophrenia or other psychotic disorder and the winner was chosen out of 5 cases submitted. The recipient of the 2005 Psychiatric Pharmacy Practice Award is Sandra Dirks, Pharm.D. Dr. Dirks is an Assistant Professor in the Department of Pharmacy Practice at Drake University and the psychiatry clinical pharmacist at Broadlawns Medical Center, Des Moines, Iowa. Dr. Dirks presented the case study "Lamotrigine-Induced Lupus: A Case Report" at the Awards Banquet on Friday March , 2005. An award for honorable mention was also presented to Natalie Boruch, Pharm.D. for her case study "A Probable Case of Zolpidem-Induced Auditory and Visual Hallucinations." The case presented by Dr. Dirks involved a 46-year-old morbidly obese Caucasian woman who was admitted to the hospital for medication evaluation and stabilization prior to placement in a supervised group home. Her past medical history included schizoaffective disorder, borderline personality disorder, and a seizure associated with highdose clozapine. Medications included risperidone 3mg twice daily, benztropine 2mg twice daily, chlorpromazine 50mg three times daily, pantoprazole 40mg daily, ranitidine 50mg twice daily, levothyroxine 0.075mg daily, furosemide 80mg daily, metoclopramide 5mg daily, spironolactone 25mg daily, potassium chloride 20 mEq twice daily, docusate sodium 200mg twice daily, and lamotriginee 25mg at bedtime. Lamotrigine was stopped for an unknown reason 3 months prior to admission while the patient was incarcerated. Lamotrigine was restarted for mood stabilization on admission at 25mg at bedtime with the plan to titrate the medication to a therapeutic dose. On day 6 of this admission, the chlorpromazine was increased to 50mg four times daily. On day 2, chlorpromazine was changed to 200mg at bedtime to resolve complaints of poor sleep. On day 6, lanotrigine was increased to 50mg at bedtime. The following day, an additional 50mg of chlorpromazine twice daily was added to the regimen. The patient had complaints of arthralgias throughout her admission, especially in the knees and ankles. Rofecoxib 25mg daily was started on day 2. Shortly thereafter, the patient.
A variety of substituents are acceptable. Potency and selectivity are altered Disposition of aromatic rings about the central ring best when on adjacent positions and pregabalin.
12 Canadian Journal of Herbalism.
Remember you're an active player in your health care and labetalol.
Research report: lamotrigine in first trimester may pose risk to fetus apr 2, 2007 nursing center a preliminary analysis of data from the north american antiepileptic drug pregnancy registry suggests that fetuses exposed to lamotrigine during the first 3 months of pregnancy may have a higher chance of being.
Legislation that would establish a uniform guardianship system throughout the state of Florida has gained two prominent backers. In September, the Florida Guardianship Education Coalition and the Florida State Health and Human Services Board both passed resolutions supporting a bill that is expected to be reintroduced in the Florida Legislature in 1999. Last year, state Rep. Larry Crow, R-Dunedin, sponsored a bill that would have created the Statewide Public Guardianship Office. The bill did not pass; however, Crow intends to refile it for the upcoming legislative session. The statewide office would be administratively housed within the Department of Elder Affairs, and would be charged with finding innovative ways of assisting local governments in meeting the need for public guardians. In addition, the office would provide needed oversight of existing programs, thus addressing a criticism of a 1995 report by the Office of Program Policy Analysis and Government Accountability. The bill requires the new office to provide training for public and lercanidipine and lamotrigine, because lamotrigine lithium.
Ily planning services, especially for groups that are underserved. The words in the ICPD Plan of Action 5, para 74 ; continue to be as true today as they were in 1994: Since unsafe abortion is a major threat to the health and lives of women, research to understand and better address the determinants and consequences of induced abortion, including the effects on subsequent fertility, reproductive and mental health and contraceptive practice, should be promoted.
Repeated Transcranial Magnetic Stimulation rTMS ; and Patients with Depression The NIMH Site continues to need volunteers 18 years or older ; with a diagnosis of unipolar or bipolar depression who wish to participate in studies evaluating the comparative efficacy of high 20 Hz ; and low 1 Hz ; rTMS vs. sham rTMS. We continue to observe differential effects on mood and brain activity with low versus high frequencies of rTMS see table, p. 4 ; , and are attempting to ascertain which patients respond best to which frequencies. A new study at a higher intensity of stimulation will test 3 weeks of 1 Hz vs. 20 Hz rTMS vs. sham over the left frontal cortex. Each patient will have an opportunity for another 3 weeks of continued rTMS if they respond, or they can cross over to the other frequency should they fail to respond in the first phase. If you are interested in the rTMS study, please call Nadine Khoury or Dr. Andy Speer at 301 ; 402-2294. Six-Week Comparison of Lamotrigine, Gabapentin and Placebo The NIMH Site also continues to recruit bipolar patients with affective disorders who have not been treated with gabapentin or lamotrigine so that we can continue to examine the efficacy of these agents compared with placebo, and establish potential clinical and biological predictors and correlates of response. Currently, the data suggest that lamotrigine monotherapy is more effective than that of gabapentin or placebo. However, many of the add-on trials in bipolar illness with gabapentin show it to be effective, and the overall clinical utility of this agent remains to be further delineated. If you are interested in pharmacological intervention with lamotrigine and gabapentin, please call Dr. Robert Dunn at 301 ; 402-2293 or Gabriele Leverich, MSW, at 301 ; 496-7180. Omega-3 Fatty Acid Protocol The final details of a protocol comparing the efficacy of 6 grams of omega-3 fatty acids compared with an identical-looking placebo were completed at the Dallas Network meeting in October. This study will start with a 4-month randomized, blind phase in which omega-3 fatty acid or placebo capsules would be added to existing ineffective regimens for patients with persistent depression or cycling. After this 4-month randomization, an 8month open extension phase with omega3 fatty acid will be available, so all patients can be reassured that they will receive a substantial exposure to the active compound. We are very excited about this first placebo-controlled clinical trial to be organized in the Network. All of the other Network trials have been comparisons of one drug to another. It is necessary to include a placebo in this trial in order to definitively demonstrate effectiveness of omega-3 fatty acids in bipolar illness, and in bipolar illness prophylaxis. Stoll et al. 1998 ; reported that omega-3 fatty acids, but not an olive oil control, were effective in preventing recurrent episodes in a small group of otherwise nonresponsive bipolar patients, in a 4-month, prospective, double-blind, placebo-controlled study see BNN Vol. 4, Issue 1 ; . This compound was particularly effective in the depressive component of the illness and produced few side effects. We are thus looking for patients who wish to participate in this double-blind, randomized study at the Network Sites see box, right ; . These studies will be conducted as outpatient clinical trials with detailed daily longitudinal life chart methodology LCM ; ratings as well as cross-sectional measures and prinzide.
In clinical trials in patients with bipolar disorder, 2 patients experienced seizures shortly after abrupt withdrawal of lamotrigine.
NB: On addition of antiepileptics psychotropics whose pharmacokinetic interaction with lamotrigine is currently unknown, the dose should be adjusted according to the recommendations applying to addition of valproate. Withdrawal of Lamotrigin Copyfarm in bipolar disorder There was no increase in incidence, degree of severity or undesirable effects after abrupt withdrawal of lamotrigine in clinical studies. Patients with bipolar disorder may therefore discontinue treatment without gradual dose reduction. Special patient groups Children below 2 years of age There is insufficient information available about the use of lamotrigine in children under 2 years. Elderly patients 65 years of age ; : No dose adjustment from recommended schedule is required. The pharmacokinetics of lamotrigine in this age group do not differ significantly from a non-elderly population. Hepatic impairment Initial, escalation and maintenance doses should be generally reduced by approximately 50% in patients with moderate Child-Pugh grade B ; and by 75% in severe Child-Pugh grade C ; hepatic impairment. Escalation and maintenance doses should be adjusted according to clinical response. Depending on the dose, the recommended dose may not be performable in patients with hepatic impairment with the current strengths of this medicinal product see section 5.2 ; . Renal impairment: Caution should be exercised when administering lamotrigine to patients with renal failure. For patients with end-stage renal failure, initial doses of lamotrigine should be based on patients' concomitant medicinal products; reduced maintenance doses may be effective for patients.
FIGURE 7-55 Resistant hypertension. Causes of failure to achieve or sustain control of blood pressure with drug therapy are listed [6, 9].
Lamotrigine combined with tegretol, dilantin, phenobarbital, or mysoline one 50-milligram dose of lamotrigine per day for weeks 1 and 2, then 50 milligrams twice a day for weeks 3 and 4, then 100 milligrams twice a day for week after that, your doctor will have you take a total of 300 to 400 milligrams a day, divided into 2 doses.
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