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Excessive intake of fats, oils, starches, sugars can create the imbalances and nutritional deficiencies that cause an unhealthy scalp and, in turn, dandruff and lovastatin. Cooperation * Psychologische Methodenleer, Faculteit der Maatschappij- en Gedragswetenschappen, Universiteit van Amsterdam Abstract To gain insight into cancer patients' health related quality of life QL ; during their disease and treatment trajectory, we need to assess changes in QL validly and sensitively. However, as a result of the disease, people may shift their internal criteria, values, and conceptualisation of life quality. This `response-shift' phenomenon poses an extra challenge to assessing QL, since it may obfuscate true change. Whereas response-shift has been described by various researchers, the proposed definitions, operationalizations and detection procedures vary widely. We propose a `psychometric' typology of 11 types of change based on Item Response Theory IRT ; and factor analysis. In this way we develop a Structural Equation Modelling SEM ; procedure to detect response-shifts and true change. The objective is of the present study is to use the method to investigate prevalence and impact of response shifts on the QL of cancer patients. Keywords patient reported outcomes, measurement of change, response shift Funding Dutch Cancer Society.
TABLE 5. SUMMARY OF MANN-WHITNEY U-TESTS * COMPARING THE PAIN THRESHOLD AND TOLERANCE OF HIGH VS. LOW HYPNOTIZABLE S S DURING HYPNOTIC AND PLACKBO ANALGESIA Time group score A Threshold pumped Tolerance Water pumped cc ; Threshold Tolerance and mevacor, because zestoretic. Isolado em casos de falhas do tratamento endodntico. A irrigao com gluconato de clorexidina tem sido sugerida em funo do seu efeito antimicrobiano e substantividade. O hidrxido de clcio - Ca OH ; 2 - tambm um efetivo agente antimicrobiano devido ao seu pH alcalino 12, 2 a 12, 8 ; . O objetivo deste trabalho foi comparar o efeito antimicrobiano do Ca OH ; associado clorexidina gel a 2% contra o E. faecalis em relao a dois outros veculos utilizados rotineiramente. Para o teste de difuso em gar, 16 placas de Petri foram inoculadas com a suspenso microbiana atravs de esfregao. Discos de papel foram saturados com as medicaes a serem testadas: Grupo I - Ca OH ; clorexidina gel a 2%; Grupo II - Ca OH ; Propilenoglicol + Paramonoclorofenol canforado; Grupo III - Ca OH ; 2 Propilenoglicol; Grupo controle - soluo salina. As placas foram incubadas por 24 horas tempo 1 ; a 48 horas tempo 2 ; . O dimetro do halo de inibio foi medido em mm, sendo os dados submetidos anlise estatstica anlise de varincia e teste de Tukey, alfa 0, 05 ; . Os resultados mostraram que o Grupo I 16, 70; A ; foi estatisticamente superior ao Grupo III 12, 05; B ; e o Grupo II 13, 57; AB ; no diferiu dos demais grupos. No houve diferena em relao ao fator tempo p 0, 516 ; . Conclui-se que a clorexidina gel pode ser associada ao hidrxido de clcio, sendo vantajosa em relao aos demais veculos em funo do seu maior potencial antimicrobiano, requerido no tratamento das leses endodnticas refratrias.
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Age: The pharmacokinetics of amphotericin B, administered as AMPHOTEC, were not related to the age of the patient. The median range ; age for the population in this study was 32 3 to years. INDICATIONS AND USAGE AMPHOTEC is indicated for the treatment of invasive aspergillosis in patients where renal impairment or unacceptable toxicity precludes the use of amphotericin B deoxycholate in effective doses, and in patients with invasive aspergillosis where prior amphotericin B deoxycholate therapy has failed. DESCRIPTION OF CLINICAL STUDIES Clinical Studies in Aspergillosis Data from 161 patients with proven or probable aspergillus infection were pooled from 5 non-comparative open label studies, one of which included emergency use patients. The patients were treated with AMPHOTEC because of failure to respond to amphotericin B deoxycholate n 49 ; , development of nephrotoxicity while receiving amphotericin B deoxycholate n 62 ; , preexisting renal impairment n 25 ; , or other reasons n 25 ; . The median age of these 161 patients 92 males and 69 females ; was 41 years range 2 months to 85 years ; . For the 155 patients with baseline neutrophil data, 33 patients 21% ; had neutrophil counts of 500 mm3. The underlying diseases included bone marrow transplant, 69 43% hematological malignancy, 51 32% solid organ transplant, 25 15% solid tumor, 3 2% and other diagnoses, 13 8% ; including surgery, 4; HIV infection, 3; immunosuppression for autoimmune disease, 3; diabetes, 2; and no known underlying disease, 1. Pulmonary involvement was the primary infection site, 118 patients 73% ; , followed by sinus, 14 9% ; , CNS, 9 6% ; , skin wound, 9 6% ; , and others, 10 6% ; including 3 with bone involvement, 2 with hepatic involvement, 2 with disseminated disease and 1 each with endocarditis, ophthalmitis, otitis, and involvement of the hard palate. The 49 patients enrolled due to failure to respond to amphotericin B had received amphotericin B deoxycholate prior to AMPHOTEC for 7 days 11 patients ; , 8 - 14 days 16 patients ; , and 14 days 22 patients ; . Patients were defined by their physicians as being refractory to amphotericin B deoxycholate therapy based on overall clinical judgment after receiving either a minimum of 7 days of amphotericin B deoxycholate or a minimum total dose of 15 mg kg of amphotericin B deoxycholate. Nephrotoxicity was defined as a serum creatinine that had doubled from baseline, increased by 1.5 mg dL or increased to 2.0 mg dL. Preexisting renal impairment was defined as a serum creatinine that had increased to 2.0 mg dL due to reasons other than amphotericin B deoxycholate administration. Classifications of diagnosis and response were based on the definitions previously developed by the Mycoses Study Group.1 A retrospective response analysis was conducted in which a "complete response" was defined as resolution of all attributable symptoms, signs, and radiographic abnormalities present at enrollment, and a "partial response" was defined as major improvement of the abovementioned parameters. The total number of responders was the sum of the number of "complete" and "partial" responses. Of the 161 patients, 80 were considered evaluable for response. Eighty-one 81 ; were excluded on the basis of inadequate diagnosis, confounding factors, or receiving 4 doses of AMPHOTEC. In the evaluable patients, the median daily dose was 4 mg kg day range 0.73 - 7.5 mg kg day ; and the cumulative median dose was 6.3 g range 0.36 - 34.4 grams ; . Median duration of treatment was 24 days range 5 - 129 days ; . Response Rates for Evaluable Patients Patient Group n ; Complete Partial Total Response Response Response Responders Rate [a] 3 5 1.

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Fifty-eight Sprague-Dawely rats were anesthetized with pentobarbital given by an intraperitoneal injection 50 mg kg ; . Each animal was also given atropine sulfate 0.8 mg kg ; to reduce tracheal secretions. Using a surgical microscope, the right femoral artery and vein were catheterized and the trachea was intubated. Pancuronium bromide 0.4 mL ; was then perfused through the femoral vein to induce muscle relaxation. Each rat was then artificially respired using a small animal respirator Harvard Apparatus, South Natik, MA, U.S.A. ; and expiratory CO2 was maintained within the physiological range using a capnometer Model 2200, Traverse Medical Monitors, Saline, Michigan, U.S.A. ; . Each animal was then placed on the stereotaxic device Narishige Scientific Instrument Laboratory, Setagaya-Ku, Tokyo, Japan ; and the rectal temperature was maintained between 36.5-37.5 using a feedback controlled heating blanket Harvard Apparatus, South Natik, MA, U.S.A. ; . To stimulate motor cortex, a metal electrode NE-120, Rhodes Medical Instruments, Inc., distributed by David Kopf Instruments, Tujunga, California, U.S.A. ; which was originally designed for recording the sensory evoked potentials in the cerebral cortex was used. The pointed tip of the electrode, with a 0.5 mm long exposed area, was inserted into the cerebral cortex perpendicular to the cortical surface. This enabled gentle contact of the round flat surface with the cortical surface. During cortical stimulation, the round area of the electrode was the anode and the pointed tip was the cathode. This electrode was designed to keep the cathode and the anode close together in order to prevent current spread. In addition, there was also a large enough surface for the activation of a large number of pyramidal neurons with a low intensity electrical current. Furthermore, the direction of the current flow was designed to be the same as the projection of the pyramidal cell bodies. A single square pulse 0.1 msec duration ; of electrical stimulus was delivered by a stimulus isolator A365D or A365, World Precision Instruments, Inc., New Heaven, Connecticut, U.S.A. ; , which was driven by a pulse generator Pulsemaster A300, World Precision Instruments, Inc., New Heaven, Connecticut, U.S.A. ; . A laminectomy was performed at L1 of the spinal cord of each rat for the placement of the epidural recording electrodes. The shape and specifications of the recording electrodes were the same as those of the stimulating elecrodes. Following the laminectomy, the electrode was inserted into the contralateral gray matter at L1 of the spinal cord. The pointed tip of the electrode was used for activation and the rounded part of the electrode was used as a reference electrode. The analog signals of the evoked potential were amplified AC amplifier, Model RPS 107, Grass Instrument Co., W. Warwick, RI, U.S.A. ; , filtered bandpass 300-1, 000 Hz ; , and averaged on an IBM-compatible personal computer system equipped with Spike 2 software CED, Cambridge, U.K. ; . Each MEP con.

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WASHINGTON The U.S. Office of Personnel Management is working to make veterans' preference for federal jobs available to more veterans, including a new revised application that allows federal agencies to accept veterans' disability letters. The revised Application for 10Point Veteran Preference, Standard Form 15, is being posted directly on OPM's Web site so agencies immediately can accept Veterans Affairs Department letters of disability, officials said. Agencies, OPM examining offices and agency appointing officials use the online application to evaluate claims for veterans' preference on applications for government jobs. The new revisions to the veterans' preference form bring it in line with VA policy, which generally considers disability letters issued since 1991 as proof of a permanent disability. To further encourage veterans into the federal system, OPM is continuing its Veterans' Invitational Program, visiting military bases and medical centers to explain veterans' preference and outline the procedures for applying for federal jobs. OPM Acting Director Dan G. Blair, who announced the initiatives in late March, said they reflect OPM's "strong emphasis on the rights of veterans, including employment opportunities." "We must ensure those who are eligible for veterans' preference receive the benefits to which they are entitled, " he said. Veterans of the armed forces have received some degree of hiring preference for federal jobs since the Civil War. Today's law, reflected in Veterans' Preference Code of 1944, as amended, and in Title 5 of the U.S. Code, ensures that veterans who are disabled or served on active duty in the military during certain specified time frames or campaigns receive preference in hiring from competitive lists of eligible applicants. It also gives these veterans preference in keeping their jobs during reductions in force. The purpose of veterans' preference, officials explained, is to recognize the economic loss suffered during military service, restore veterans to a favorable competitive position for government jobs, and acknowledge the debt owed to disabled veterans. More details about veterans' preference are posted on the OPM Web site. Several studies have established a link between PPAR activation and epidermal differentiation. Fibrates, which are PPAR ligands, induce differentiation and inhibit proliferation of human keratinocytes in vitro 42 ; , and in normal 43 ; and hyperproliferating 44 ; mouse skin in vivo, but are inactive in PPAR -deficient mice 43 ; . Farnesol also stimulates PPAR dependent differentiation in epidermal keratinocytes 45 ; . Topical PPAR agonists have weak preventive effects on tumor promotion in mouse skin, despite up-regulation of PPAR in untreated tumors compared with normal epidermis 46 ; . In this regard, PPAR expression is also up-regulated in human prostate adenocarcinomas 47 ; . The significance of this observation is as of yet unknown.
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