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Drs. Goldstein and Kung are honored for their discovery of Orrho Biotech's monoclonal antibody to prevent transplant rejections, ORTHOCLONE OKT3. In the late 1970s, about half of all kidney transplants failed, even when patients were given standard immunosuppressive therapy to prevent rejection. To find out whether the therapy was actually reaching the white blood cells--called "T" lymphocytes--that were attacking the donated kidney, Drs. Goldstein and Kung of Johnson & Johnson's Ortno Pharmaceuticals Corp. created a series of synthetically created, identical antibodies known as the OKT series that would tag and identify these "T"cells. They suspected that one of their novel antibodies, OKT3, might even clear these cells from the bloodstream and reverse the rejection. Although many in the scientific community doubted monoclonal antibodies could be used for therapy, in August 1981 the New England Journal of Medicine reported that transplant surgeons at the Massachusetts General Hospital in Boston had successfully treated two patients suffering acute rejection of their donor kidneys with the Ortho's experimental product, later trademarked ORTHOCLONE OKT3. When FDA received the product licensing application for ORTHOCLONE OKT3 in June 1986, the agency had approved only one biotechnology product--human insulin--as a therapeutic agent. Now, more than a dozen biotechnology drugs and vaccines are on the market. Ocufen . Ocuflox . Ocupress Ortho-Cept Ortho-Cyclen Oxybutynin OxyContin. Steps for women who want to become pregnant a woman who wishes to become pregnant and has been seizure-free for two or more years may attempt to discontinue drugs under her physicians supervision.

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At a brook which pill dance in the fitness, wild sees reflux the tops, and the comps birth the pharmaceuticals just closerring the fingers buy. Rees Cameron, Murray Barclay, Bruce Dobbs Abstract Aims Patients with chest pain of uncertain origin are often referred to gastroenterology to assess for possible oesophageal causes. Oesophageal spasm is difficult to ascertain with stationary manometry, as pain seldom occurs during this brief study. Twenty-four-hour ambulatory manometry and oesophageal pH recording AMP ; offers the opportunity to correlate pain symptoms with abnormal motility or acid reflux for more definitive diagnosis. AMP has been available at Christchurch Hospital since 2000 and we describe our experience. Methods Thirty-seven patients 23 female, 14 male ; underwent AMP between January 2000 and January 2004. Tracings were analysed by automated software and manually by an experienced scientist and gastroenterologist. Case-notes were reviewed for history and drug data. Results Thirty-three patients 89% ; experienced typical pain and or dysphagia symptoms during AMP. Twenty-one had no correlation between symptoms and pH or manometric abnormalities, excluding reflux disease or an oesophageal hypercontractile disorder as a cause of symptoms. Only one patient had oesophageal spasm proven. One patient's pain correlated strongly with acid reflux. Seven others had reflux episodes during AMP with less consistent pain correlation. At least six patients required treatment for ischaemic heart disease after a negative AMP result. Conclusions AMP has been a useful additional investigation for chest pain and was able to exclude oesophageal causes of pain in most patients studied. Oesophageal spasm appears to be a rare cause of chest pain in Christchurch. When a diagnosis was made on AMP, it was most often gastro-oesophageal reflux disease. Patients who have recurrent chest pain with an apparently normal coronary angiogram, dynamic echocardiogram, or treadmill electrocardiogram ECG ; test, are often referred to Christchurch Hospital's Gastroenterology Service for assessment. Studies have shown that 2060% of patients with recurrent noncardiac chest pain NCCP ; have oesophageal abnormalities when assessed by endoscopy, manometry, provocation tests, and or 24 hour oesophageal pH testing.1 In the majority of cases, the disorders are gastroesophageal reflux disease and oesophageal dysmotility. The presence of these abnormalities does not imply causation, however, unless they occur at the time of symptoms. A difficulty with stationary manometry is that symptoms occur rarely during the procedure, and provocation tests such as intravenous edrophonium provoke non-specific motor responses that do not differentiate symptomatic from asymptomatic individuals.2 These tests also have the potential to provoke chest pain from organs other than the oesophagus.3 Accordingly, the American Gastroenterology Association asserts that.

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