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71 ; ETABLISSEMENTS ROCHAIX NEYRON [FR FR]; Route de la Tuilerie, F01100 Arbent FR ; . for all designated States except pour tous les tats dsigns sauf US ; 72, 75 ; DUPRAZ, JeanFranois [FR FR]; 66, route de Geovresset, F01100 Veyziat FR ; . DUPRAZ, JeanLuc [FR FR]; 67, avenue de la Libration, F39200 SaintClaude FR ; . 74 ; RHEIN, Alain; Cabinet BlegerRhein, 10, rue Contades, F67300 Schiltigheim FR ; . 81 ; ZW; AP GH GM KE Published Publie : c.
As used in this description, the total of base salary, annual cash incentive compensation and equity incentive compensation for each executive is referred to as "Total Direct Compensation". We believe that the elements of our compensation program are important components of a well-designed, balanced, competitive compensation program. Determination of Competitive Compensation The Compensation Committee has retained Towers Perrin, a nationally-recognized compensation consulting firm, to assist the Committee in designing and assessing the competitiveness of our executive compensation program. In determining the relative weighting of salary, annual cash incentives and equity incentive elements of the compensation program and the target level of these elements of compensation for our executives, the Compensation Committee considers survey data from companies in the water utility industry, the broader utility industry and general industry the "Composite Market" ; compiled by Towers Perrin. The water utility industry data was drawn from the SAJE Consulting Compensation Survey, and the broader utility industry and general industry data was drawn from Towers Perrin's executive compensation database. The Composite Market represents an equal blending of the utility and general industry data. Due to the relatively limited number of investor-owned water utility companies, the Compensation Committee believes that this broad survey data approach provides reasonable and reliable data for use in determining competitive compensation levels. Towers Perrin develops competitive compensation benchmarks for each of the named executive officers using this survey data. Towers Perrin uses regression analysis to size-adjust the survey data for each named executive officer's scope of responsibilities, where possible. The Compensation Committee has targeted competitive compensation levels for salaries and annual cash incentive awards at the 50th percentile of compensation levels for utility companies and competitive compensation levels for equity incentives at the 50th percentile of a 50 mix of utility companies and general businesses in the Composite Market. We believe that a blended approach is appropriate for equity incentives in order to place a strong focus on creating value for Aqua America's shareholders and to enable us to compete for talent both within and outside of the traditional utility industry. We emphasize pay for performance, especially for our higher level executives. Therefore, the named executive officers tend to receive a sizable portion of their total annual compensation from annual cash incentives and equity incentives. For 2006, the portion of the target annual Total Direct Compensation for the named executive officers attributable to base salary ranges from 29% for our Chief Executive Officer to 62% for other executives, and the portion attributable to cash and equity incentives ranges from 71% for our Chief Executive Officer to 38% for other executives. Since it is impossible to predict the extent to which performance objectives and financial targets will be achieved, annual cash incentives are valued at their target value and equity awards are valued at their fair market value at the time of grant for purposes of setting the portion of the executive's total compensation package represented by these elements. Payouts of prior cash incentives and changes in the value of equity incentives granted in previous years are not taken into account in determining the amounts of current awards, for example, relafen 750.
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So when it comes to the issue of weight regain following bariatric surgery, I tell the surgeons to expect it. "Now, don't give up. Don't start yelling at the patient." I've looked here at the things that we do that can help. Number one is look for the addition of medicines that could cause weight gain. Because we know the medicines can cause weight gain, and it is a straightforward problem to manage. In this case, we didn't see it. So even though they have surgery, that can have an impact, can stimulate appetite, and start this vicious cycle rolling. We get back to basics. We have the patient keep food records. That has always been shown to be of value. We review their diet, behavior and activity program with them again, like they've never been here. And we see them more frequently because surgery patients typically are seen only once or twice a year. We say, "Look, we've got to go back into relapse prevention, and we want to see you at least once a month." We see them more frequently until we get things under control, for example, relafen prescribing.
ARTICLE XII. BENEFITS AND SERVICES NOT INCLUDED ARTICLE XIII. OTHER HEALTH PLANS AND BENEFIT PROGRAMS ARTICLE XIV. OTHER PROVISIONS ATTACHMENT A, PRESCRIPTION DRUG COVERAGE ATTACHMENT B, MENTAL HEALTH AND SUBSTANCE ABUSE ATTACHMENT C, USABLE ATTACHMENT D, RATES.
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Tract. Investigation of a patient suspected of having LCH should therefore include skeletal survey radionucleide bone scan is less helpful than plain X-rays ; full blood count and film, liver function tests and early morning urine osmolality proceeding to water deprivation test if indicated. Other tests e.g. lung function tests, bone marrow aspiration should only be added if clinically indicated [3]. The definitive diagnosis should then be established by biopsy of a suitable and accessible lesion - usually a bony lesion, skin rash or lymph node. Histology of a typical LCH lesion shows an infiltrate of histiocytes together with varying proportions of macrophages, lymphocytes, eosinophils and giant cells with occasional neutrophils and plasma cells. The 'LCH cells' express the phenotype of normal Langerhans' cells which are dendritic antigen-presenting cells derived from bone marrow.The 'LCH cell' is thought to be less capable of antigen presentation than its normal counterpart and is presumed to be a Langerhans' cell frozen' in an early stage of activation. Both contain characteristic Birbeck granules which are tennis racketshaped intracytoplasmic organelles.The cells can also be identified by a number of surface antigens of which the CD la glycoprotein is the most specific. Immunophenotypic markers include S-100 protein, ATP-ase, aD-mannosidase, peanut agglutinin PNA ; , interferon Y receptor and placental alkaline phosphatase PLAP ; . The last three molecules appear on 'LCH cells' but not normal Langerhans' cells [4]. In 1987 the Histiocyte Society established 'confidence levels' for diagnosing LCH [5] .The appearance of conventional histological characteristics allows a 'presumptive diagnosis' to be made. If stains for at least two of S-100 protein, ATP-ase, aD-mannosidase or PNA are positive the term 'diagnosis' is used. The highest level of significance is attached to either the presence of Birbeck granules on electron microscopy and ritalin.
The incidence of birth defects following COC exposure is no higher than expected among any group of women having a planned baby Bracken 1990 ; . The advice that a pregnant woman should avoid all drugs, especially in the first trimester, remains the ideal. Exposure to COC during pregnancy should never be used as grounds for recommending therapeutic abortion.
The arthritis of SLE and RA is sometimes initially approached with a category of drugs called NSAIDs, or non-steroidal anti-inflammatory drugs. These drugs do exactly what their name implies: reduce symptomatic inflammation. However, they do not have any effect on underlying disease processes. Many drugs fall into the NSAID category, including naprosyn Naproxen ; , nabumetone Relsfen ; , celecoxib Celebrex ; , melocicam Mobic ; and aspirin, to name a few. An advantage of NSAIDs is that they do not necessarily have to be taken daily for arthritis that flares up or is transient comes and goes ; . Though helpful for many, these drugs are not appropriate for everyone due to their potential to cause gastrointestinal, heart, and blood pressure problems as well as other adverse side effects and rohypnol.
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Basel, January 19, 2006 Commenting on the results, Dr. Daniel Vasella, Chairman and CEO of Novartis, said, "It gives me great pleasure to present once again a strong performance and record results in 2005. We gained market share and concluded strategic acquisitions to strengthen our leadership position in areas with high growth potential and unmet patient needs. Our strong performance has allowed us to increase our access-tomedicines programs to reach 6.5 million people in 2005 with USD 696 million of products donated or sold at cost. We are confident of delivering in 2006 another year of dynamic growth with record sales and earnings and serevent.
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SCENARIO D3 - 10% OF INTERNATIONAL TRAFFIC ROUTED VIA THEINTERNET .45 TABLE 6.1: .48 SUMMARY OF SIMULATIONS.48 TABLE 6.2: .49 COMPARISON OF ADVANTAGES: SYMMETRICAL ASYMMETRIC TERMINATION CHARGE.49 and serzone.
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Aortofemoral bypass for aorto-occlusive disease has at best a 60 to 70% patency because of progression of the disease at the groin, and in the SFA and profunda. Moderator: A 60% five year patency? Dr. Ascher: I would say 60 to 70%, for aortofemoral occlusive disease. On patients with extensive atherosclerotic disease these patients are not the common variety of single lesion, you know hypertensive. Moderator: The SSAs are open? Dr. Ascher: Yes, they are. He has a proximal stenosis on the right SSA, but otherwise they are open. I would have to review the current data on aortofemoral, but I wouldn't say it was 80 to 90%. On the other hand, a balloon angioplasty in the iliac system is reported to be up 75% patency at 5 years and better with stents, so I not so sure that it is that much better. I mean the operation is that much better than balloon angioplasty and stenting the iliacs. I also would be cautious about the extent of iliac angioplasty. Moderator: I would agree with Dr. Jordan. I have become less enthusiastic about endovascular treatment for diffuse aortoiliac disease, especially when the external iliac arteries are involved. Our vascular surgeons here at Pennsylvania Hospital have been performing iliac balloon angioplasties for several years and we have been extremely disappointed with the long-term results of external iliac balloon angioplasty. And for that reason, we discussed that as an option, however, I clearly told him that I would favor a more aggressive approach, which is what he was more in favor of also. Dr. Ascher: What if you had done the angioplasty with a stent and waited 2 to 3 years? What have you basically lost? You have to agree that there is a possibility that it may work, long-term. Dr. Jordan: I would agree with that, Enrico. I think it is very acceptable to go with a balloon approach first, but the ones that I think have the most success are the focal segmental common iliac lesions, not the ones that are long and diffuse. You now have an angry patient because he has endured 3 to 4 months with minimal improvement and he wants definitive improvement. That is why I would be more aggressive, rather than take an intermediate approach. Dr. Ascher: The reason is, not that I do angioplasties every day, and not arterial constructions, but I mostly concerned about the distribution of his mesenteric circulation. I a little bit concerned about clamping the aorta without addressing his mesentery vessels, the chance of damaging the mesenteric circulation is real. I think the chance of embolizing from such an atherosclerotic aorta is also real. Dr. Jordan: Does your MRA routinely evaluate the mesenterics and the renals? Are the results accurate? Dr. Ascher: No, we don't. The MRA is very accurate. And for the viscera an MRA is excellent, really excellent!
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HB, LC and BT, undergoing primary EBV infection showed that most colonies expressed a single productively rearranged TCR transcript confirming their clonality Fig. 5 ; . Considerable heterogeneity was observed in the T cells responding to RAKFKQLLQ both within and among the three different donors. Although for mixed colonies that expressed more than one productively rearranged TCR chain, the specific antigen receptor could not be assigned, heterogeneity selection was also evident from the non-recurrence of the transcripts. Of the RAKFKQLLQ-specific TCR, no preferential usage of specific TCRV or TCRJ genes was found; five of seven used unique TCRV gene elements and three of seven used unique TCRJ gene elements. Of the few clones that shared either TCRV [LC50 and BT I ; 173] or TCRJ [LC5 and BT I ; 142; LC34 and BT I ; 173] gene usage, none were found to share both TCRV or TCRJ usage. The complementarity determining region 3 CDR3 ; , that directly contacts the peptide epitope 3941 ; , was also unique to each T cell clone having no structural motifs in common with any other chain. However, a CDR3 length restriction of 913 amino acids was observed in all of the clones, indicating structural constraints on the molecular interactions between the TCR and the peptideMHC target [reported CDR3 lengths range of 517 amino acids 42 ; ]. Another notable feature of the RAKFKQLLQ memory response in these donors was the lack of detection of recurrent clonotypes, reinforcing the heterogeneity of the responding repertoire. Maintenance of TCR diversity in the RAKFKQLLQ-specific CTL response following acute infection and in healthy virus carriers Having established TCR diversity selection during primary infection for the RAKFKQLLQ response we next monitored the effects of persistent virus infection on chain development. RAKFKQLLQ-specific colonies were generated at two addi.
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Chairman CEO Eugene N Melnyk Dr Douglas J P Squires To retire June 2007. Previously Executive Chairman Joined November 2004. Previously President and CEO, MDS Pharma Services Promoted December 2006 from VP, Finance & Corporate Affairs. Joined 1997. Also worked for Pharma Patch, SmithKline Beecham, Bencard Allergy Laboratories Joined May 2005. Previously V-P, Global Business Development, Sanofi-Aventis. Also worked for Johnson & Johnson J&J ; Appointed July 2006. Previously with BMO Financial Group Appointed May 2006. Previously CMO, Global IQ Appointed April 2006. Previously with MDS Pharma Services, for instance, relafen back pain.
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Experience with tests of insulin resistance but HOMA is a well regarded technique and taken in conjunction with previous work the approach used seems reasonable. %B should be included in Results, even if only to show it doesn't vary with Fokl, since this is a measure of islet cell function in terms of insulin secretion. In the revised manuscript, we have added a new paragraph in the Discussion section to address the issues raised by Dr. McDermott. It is in page 8, lines 8-20. In addition to showing the results of ANOVA, we not only discuss the rationale for pooling, which is a common practice in this type of genetic study, but also provide the reference 20 ; , which shows no demonstrable difference in the function between the Ff and ff genotypes. We are considering looking at the Taq I and other polymorphisms at the VDR gene locus. We did include the results of beta cell function in the Result section Page 6, line 22 and page 7, lines 14-15 ; , and Discussion section page 7, line 21 ; , as well as in Tables 1 and 2. Suggested additional reference Pani Ma et al. Vitamin D receptor allele combinations influence genetic susceptibility to type I diabetes in Germans. Diabetes. 2000; 49 3 ; : 504-7. The reference has been added on page 9, lines 18-10 as reference 23. Typos Pg 2 "glucose challenge" It has been corrected. Pg 8 - The sentence beginning "However, it was less certain" might be expanded to indicate that in ref 18 "there was excess transmission of bT and bAT extended haplotypes to affected individuals but no evidence for excess transmission of Taq I and Apa I alleles alone". Restriction enzymes are usually italicised e.g Bsml. The reference and statement have been added on page 9, lines 18-10 as reference 23. The name of restriction enzyme is in Italic. Pg 9 - Last sentence - "Furthermore additional studies in Caucasians and other .etc. Pg 10 - In Study Subjects "the study has complied" might. It has been corrected. Pg 11 - DNA extraction " PCR ; was carried out ?? reaction 11 ul ; " - the volume used is unclear, as with other volumes referred to. It has been corrected. In summary I enjoyed reading this paper and I think the authors deserve credit for having studied the Fokl VDR polymorphism in glucose tolerant subjects; with some modifications, provided the findings with Fokl are not confounded by variation in 25 OH ; vitamin D with genotype, this could be an important contribution to the literature.
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