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Figure 6. Longitudinal analysis of Ki-67 antigen expression in CD4 A ; and CD8 B ; T lymphocyte subsets and total populations. Decline of the number of total gray circles ; , naive black circles ; , CD27 memory black triangles ; , CD27 memory black squares ; , and CD27 effector black diamonds ; Ki-67 T cells is shown. Sequential patient values were compared using the Wilcoxon Signed Ranks test, and the Mann-Whitney U test was used for comparison with healthy individuals * P .05.
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Drug overview Coreg and heart failure Coreg in post-myocardial infarction patients Alpha blockers Overview of the global alpha blockers market Key trends in the global alpha blockers market Comparison of key brands in the alpha blocker class Diuretics Overview of the global diuretics market Key trends in the global diuretics market Comparison of key brands in the diuretic class Centrally-acting anti-hypertensives Overview of the global centrally-acting anti-hypertensives market Key trends in the global centrally-acting anti-hypertensives market COUNTRY ANALYSIS Significance of major countries in the global anti-hypertensive market Overview of the global anti-hypertensive market Breakdown of the country markets by class Issues specific to the European markets The role of reference pricing The effects of parallel importing Summary of global market factors The US anti-hypertensive market Environmental drivers in the US Positive impacts Negative impacts Litigation against companies: inflating prescription drug prices Three tier co-payment plans The Japanese anti-hypertensive market Environmental drivers in Japan The French anti-hypertensive market Environmental drivers in France Healthcare reforms The German anti-hypertensive market Environmental drivers in Germany The Italian anti-hypertensive market Environmental drivers in Italy The Spanish anti-hypertensive market Environmental drivers in Spain The UK anti-hypertensive market Environmental drivers in the UK The National Service Framework LIFECYCLE MANAGEMENT Global drug class lifecycle in anti-hypertensives Reformulations in anti-hypertensives Lotrel: successful combination treatment Lipitor + Norvasc: developmental line extension CALM: Atacand and Zestril Patent extensions New indications for anti-hypertensive drugs Additional cardiovascular indications Lifecycle management case studies Norvasc: can it continue to maintain market share? Merck & Co: launching Cozaar to replace Vasotec THE FUTURE DECODED Market forecasting methodology Disease market growth Disease drug class growth Individual drug growth Trends in the anti-hypertensive market to 2008 Global market forecast.
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Gadkari JV; Joshi VD Department of Physiology, L. T. M. Medical College, Sion, Bombay, Maharashtra. J Postgrad Med India ; Jul 1991, 37 3 ; p128-31 The effect of raw garlic on serum cholesterol, fibrinolytic activity and clotting time was studied in 50 medical students of the age group of 17 to years before and after feeding raw garlic . All pre-experimental values ranged within normal limits. The volunteers were then divided into experimental and control groups. The subjects of the experimental group were given 10 gm of raw garlic daily after breakfast for two months. Fasting blood samples of all the subjects were investigated after two months. In the control group, there was no significant change in any of the above parameters. In the experimental group, there was a significant decrease in serum cholesterol and an increase in clotting time and fibrinolytic activity. Hence, garlic may be an useful agent in prevention of thromboembolic phenomenon and oxycontin.
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In response to a perceived need to focus on the fisheries sub-sector the Section was recently renamed and its efforts refocused to include aquaculture and fisheries. This initiative is guided by a National Policy and Development Strategy for the fisheries sub-sector Box 2 ; . Table 4: Fisheries Proje cts in collaboration with the Savannakhet Livestock and Fisheries Section Donor AIT Outreach, Bangkok, Thailand ODA ; MRAG, Imperial College, London, UK ODA ; IDRC, Canada UNDP Project To promote small scale fisheries development in every District Resource management and sampling Counterparts Nick Innes Taylor Notes Institutional strengthening and penicillin.
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Skin lesions may be linked to the biofilm of a bacteria, Stenotrophomonas maltophila, and this possibility requires further histopathologic investigation. In general, pathologists look for signs of known diseases and, thus, may miss clues of Morgellons disease in biopsies. There is preliminary information that Morgellons fibers are made of cellulose, but this information has been neither formally evaluated nor confirmed. In a classic study, Hall et al.[9] identified fibers composed of a cellulose-protein complex as a minor constituent of mammalian connective tissue, and increased amounts of these fibers were noted in tissue from patients with scleroderma and other pathologic skin conditions. More recent research has demonstrated synthesis of cellulose fibers by certain Gram-negative bacteria and fungi.[10-13] Studies using newer carbohydrate microarray technologies may unlock the mystery of these fibers.[14] 6. Differential Diagnosis and Association with Lyme Disease Differential diagnoses of Morgellons disease includes filariasis and the perforating dermatoses. Filariasis is a tropical nematode infestation characterized by pruritic skin lesions and lymphatic obstruction.[15, 16] Eosinophilia is common, and microfilariae are often identified in biopsy samples from skin lesions. In contrast, lymphatic obstruction and eosinophilia are rarely seen in Morgellons patients, and nematodes have not been identified in skin biopsy samples from these individuals. While filariasis may respond to treatment with antiparasitic medications such as ivermectin, [16] antiparasitic therapy does not appear to be useful in treating Morgellons disease. The perforating dermatoses are a group of skin diseases characterized by elimination of elastic or collagen fibers from the upper dermis through the skin.[17-20] There are five members of this group: Kyrle's disease, perforating folliculitis, reactive perforating collagenosis, elastosis perforans serpiginosa, and acquired perforating dermatosis.[17] The perforating dermatoses are associated with hereditary diseases including Ehlers-Danlos syndrome, osteogenesis imperfecta, Down syndrome, and Wilson disease. They may also be seen in patients with brittle diabetes mellitus or dialysis-dependent renal failure.[17-20] These dermatoses are distinct from Morgellons disease because the protruding fibers are made up of elastic or collagenous tissue that is easily identified by histopathology.[18] In addition, Morgellons patients generally do not have the rare hereditary conditions or severe metabolic abnormalities associated with the perforating dermatoses. Conversely and plavix.
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In muscular dystrophy the solvents, xylene and toluene are seen to accumulate in muscles. These also accumulate in brain and nervous tissue! See Alzheimer's page 136 and multiple sclerosis, page 104 ; . Could it be that these solvents are actually present in the nerves of the muscles? Fortunately these solvents will leave your body, by themselves, in five days after you stop consuming them! Stop drinking all store bought beverages, including water and powders that you mix, and including health food varieties. Water claims and health food powder claims sound as convincing and strong as a twelve inch plank to walk on. But if the plank leads out over the side of a ship, would you walk it? Throw all your possible sources of solvents out. Flavored foods are the chief offenders cold cereals, sweets and candy too ; . But of course, you should check in your basement or attached garage for cleaning solvents. Places where painting is done or automobiles are worked on should be off limits to you. If you've been wondering whether you have muscular dystrophy, which I consider to be a fluke disease, search your muscles electronically. Use prepared slides of flukes along with a sample of hamburger meat to represent your muscles. If flukes have already taken up residence.
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Rachel Klein, "How will the Medicare Rx Drug Bill Affect Medicaid?" Families USA "Health Action 2004" Conference. January 23, 2004. Power point presentation available online at : familiesusa site DocServer Rachel %20Klein s Dual Eligibles Presentation t?docID 2612; Federal poverty level data available online at aspe.hhs.gov poverty 04poverty.shtml 2 Kaiser Family Foundation Harvard School of Public Health, "Views of the New Medicare Drug Law: A Survey of People on Medicare, " Summary and Chartpack. August 2004. : kff medicare pomr081004pkg 3 69 FR 46632 August 3, 2004 ; : gpoaccess.gov fr index 4 The recent historical average, 2.38%, was calculated by the Joint Economic Committee Minority Office using the average of the last 10 Social Security COLAs 1994-2003 ; , based on CPI-W. The COLA historical table can be found at : ssa.gov history briefhistory3 #colas; Public Law 108-173: The Medicare Prescription Drug, Improvement, and Modernization Act of 2003. Section 1860D-14. Available online at : thomas.loc.gov . 5 38.15 prescription average includes refills. Agency for Healthcare Research & Quality, 2001 Full Year Consolidated Data File. Generated using MEPSnet HC on August 18, 2004. : meps.ahrq.gov 6 Pharmaceutical Assistance Contract for the Elderly PACE ; , Annual Report to the Pennsylvania General Assembly: January 1 December 31, 2003, Pennsylvania Department of Aging. April 2004. Drugs are in order of volume ; : Lipitor 10 mg ; , Plavix, Fosamax, N9rvasc 5 mg ; , Celebrex, Zocor, Prevacid, Pr otonix, Lipitor 20 mg ; , Norvsac 10 mg ; , Furosemide generic ; , Omeprazole generic ; , Toprol XL, Nexium, Xalatan, Digitek generic ; , Metoprolol Tartrate generic ; , Vioxx, Zocor, Isosorbide Mononitrate generic ; . : aging ate.pa aging lib aging 2003 Annual Report 7 The recent historical average, 2.38%, was calculated by the Joint Economic Committee Minority Office using the average of the last 10 Social Security COLAs 1994-2003 ; , based on CPI-W. The COLA historical table can be found at : ssa.gov history briefhistory3 #colas. 8 John Holahan and Alan Weil, "Block Grants are the Wrong Prescription for Medicaid, " Health Policy Online, No. 6, Urban Institute; May 27, 2003. : urban url ?ID 900624 9 Families USA, "Medicaid: Research Shows the Negative Impact of Out-Of-Pocket Costs on Low -Income People, " August 2001. : familiesusa site DocServer Costsharing2 ?docID 641 10 Rachel Klein, "How will the Medicare Rx Drug Bill Affect Medicaid?" Families USA "Health Action 2004" Conference. January 23, 2004. PowerPoint presentation available online at : familiesusa site DocServer Rachel %20Klein s Dual Eligibles Presentation t?docID 2612; Federal poverty level data available online at aspe.hhs.gov poverty 04poverty.shtml 11 U.S. Bureau of Labor Statistics, Division of Occupational Employment Statistics. "May 2003 State Occupational Employment and Wage Estimates." : bls.gov oes 2003 may oes ca #b00-0000; U. S. Census Bureau, "Housing Costs of Renters: 2000, " Census 2000 Brief, May 2003. : census.gov 12 Kaiser Commission on Medicaid and the Uninsured, "Dual Eligibles: Medicaid's Role in Filling Medicare's Gaps, " March 2004. : kff medicaid 7058 13 Kaiser Family Foundation, State Health Facts Online: "Retail Prescriptions Filled Per Capita by Age, 2003." Accessed on August 30, 2004. : statehealthfacts.kff 14 Jennifer Ryan and Nora Super, "Dually Eligible for Medicare and Medicaid: Two for One or Double Jeopardy, " National Health Policy Forum Issue Brief, No. 794, September 30, 2003. : nhpf pdfs ib IB794%5FDuals%5F9%2D30%2D03%2Epdf 15 Leighton Ku and Matthew Broaddus, "The Six Million Medicare Beneficiaries Excluded from Prescription Drug Benefits Under the Senate Bill are Disproportionately Minority, " Center on Budget and Policy Priorities; September 9, 2003. : cbpp 9-9-03health 16 State-run Medicaid programs generally do not cover prescription drugs for the following medical conditions: cosmetic hair loss, fertility sexual dysfunction, weight control, or smoking cessation. Also, Medicaid programs generally do not cover medications in the "investigative" stage not formally approved by the Food and Drug Administration. Some states require prior authorization for prescription therapies such as treatment for cancer, HIV AIDS and mental illness as well as for addictive medications ie: OxyContin ; . Kaiser Commission on Medicaid and the Uninsured, "Medicaid Outpatient Prescription Drug Benefits: Findings from a National Survey, 2003, " December 2003. : kff medicaid loader ?url commonspot security getfile &PageID 30030 17 Cristina Boccuti, Marilyn Moon, and Krista Dowling, "Chronic Conditions and Disabilities: Trends and Issues for Private Drug Plans, " The Commonwealth Fund. October 2003. : cmwf publications publications show ?doc id 221565 18 Kaiser Commission on Medicaid and the Uninsured, "The New Medicare Prescription Drug Law: Issues for Dual Eligibles with Disabilities and Serious Conditions, " June 2004. : kff medicaid 7119 19 Public Law 108-173: The Medicare Prescription Drug, Improvement, and Modernization Act of 2003. Section 1860D-14. Available online at : thomas.loc.gov . 20 38.15 prescription average includes refills. Agency for Healthcare Research & Quality, 2001 Full Year Consolidated Data File. Generated using MEPSnet HC on August 18, 2004. : meps.ahrq.gov.
Western Health Advantage Formulary Antilipidemic Agents G Niacin.NIACIN NIASPAN G Gemfibrozil .LOPID Fenofibrate.TRICOR Colestipol Bulk Powder.COLESTID G Lovastatin .MEVACOR Lovastatin niacin .ADVICOR G Simvatatin.ZOCOR Simvastatin ezetimibe.VYTORIN G Cholestyramine Resin .QUESTRAN or LIGHT Colestipol tablets.COLESTID TABS Beta-Adrenergic Antagonists "Non-selective" G Propranolol.INDERAL Propranolol LA .INDERAL LA G Nadolol .CORGARD G Sotalol .BETAPACE Beta-Adrenergic Antagonists "Selective" G Atenolol .TENORMIN G Metoprolol Tartrate .LOPRESSOR Metoprolol SR.TOPROL XL Calcium Channel Blockers G Diltiazem RDIZEM G Nifedipine .ADALAT G Nifedipine ER and SR .ADALAT CC G Verapamil LAN G Verapamil SR LAN SR G Felodipine ENDIL G Diltiazem XR .TIAZAC G Amlodipine.NORVASC PA Nimodipine * .NIMOTOP * For Subarachnoid Hemorrhage Cardiac Glycosides G Digoxin .LANOXIN Centrally Acting Antihypertensives G Clonidine TAPRES G Methyldopa .ALDOMET Clonidine Patches TPRES-TTS G Guanfacine .TENEX Combination Alpha-Beta Antagonist G Labetalol .TRANDATE Carvedilol.COREG.
Characteristics of the Prospective Randomised Evaluation of the Vascular Effects of Norvasv Trial PREVENT ; . J Cardiol 1997; 80: 10871090. Nissen SE, Tuzcu EM, Libby P, Thompson PD, Ghali M, Garza D, Berman L, Shi H, Buebendorf E, Topol EJ; CAMELOT Investigators. Effect of Antihypertensive Agents on Cardiovascular Events in Patients With Coronary Disease and Normal Blood Pressure The CAMELOT Study: a randomized controlled trial. JAMA 2004; 292: 22172226. Staessen JA, Thijs L, Birkenhager WH. VALUE: analysis of results. Lancet 2004; 364: 931. Staessen JA, Wang JG, Thijs L. Cardiovascular protection and blood pressure reduction: a meta-analysis. Lancet 2001; 358: 13051315. Teo K, Yusuf S, Sleight P, Anderson C, Mookadam F, Ramos B, Hilbrich L, Pogue J, Schumacher H; ONTARGET TRANSCEND Investigators. Rationale, design, and baseline characteristics of 2 large, simple, randomized trials.
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Per the request of the Trade Policy Staff Committee TPSC ; PhRMA is evaluating draft legislation aimed at ammeding the law of 1960 and will provide this analysis as soon as possible. We have learned thus far that local manufacturers are now being encouraged by the Ministry of Health to launch their copies of major innovative products without permission or authorization by the right holder. Local company Galenica has launched a generic of Pfizer's Zithromax last month November 2002 ; , and at least three other local copy-cat versions of Zithromax are currently under regulatory review. At least two copies of Pfizer's Norvasc, an anti-hypertension treatment, are under regulatory review as well. Both Zithromax and Norvascc are protected by patent until 2007-2008 in major markets.
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1 Central Blood Pressure Better Predicts Cardiovascular Events Than Does Peripheral Blood Pressure The Strong Heart Study Mary Roman, Cornell Univ, et al Epidemiology: Traditional CVD Risk Factors, 4: 00 pm, Sunday November 13. 2 Differential Impact of Blood Pressure-Lowering Drugs on Central Arterial Pressure Influences Clinical Outcomes Principal Results of the Conduit Artery Functional Evaluation CAFE ; Study in ASCOT Bryan Williams, Univ Liecester Late Breaking Clinical Trials 1, 3: 45 Sunday November 13. 3 New Data Show Hypertensive Patients Taking Norvasc-Based Regimen Achieved Better Central Blood Pressure Control. Yahoo Financial New, Sunday 13th November, 2005. 4 Norvaxc better for lowering aortic blood pressure. Reuters, Sunday 13th November, 2005. 5 CAFE: Lower central aortic blood pressures with amlodipine and perindopril. thekidney , Sunday 13th November, 2005.
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The Medicines Control Agency and the Medical Devices Agency will merge in April 2003. Responsible for the regulation of medicines and medical devices, the single agency will have a new chairman and nonexecutive members on its board. An increased amount of crossover between the two fields is the reason for the merger.
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