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Salbutamol

At bedtime. Symptom scores were recorded daily by the patients and included salbutamol use 15 points ; , night asthma 15 points ; , day asthma 15 points ; , and exercise-induced asthma 15 points ; . For basophil releasability tests, blood was withdrawn around 8 a.m. on the day before the treatment began and 48 hours, 1 week and 4 weeks following the start of the treatment. The withdrawn blood was divided into two equal parts one for histamine releasability and the second for cysLT release. Spirometry was performed before the treatment period and 4 weeks later, at the same time of day. No other treatment was given, except for salbutamol on demand with the last dose given more than 12 hours prior to the blood test. The patients' medical condition was stable throughout this period and they did not require any additional therapy. 1. Amoxicillin Syrup Caps 2. Amoxicillin Caps Cloxicillin 3.Cloxicillin Caps 4. Azithromycin Caps 5. Cefadroxil Tabs 6. Cefalexin Caps 7. Ciprofloxacin Tabs 8. Cotrimoxazole Sus Tabs 9. Doxycycline Tabs Caps 10. Tetracycline Caps 11. Erythromycin Tabs 12. Norfloxacin Tabs 13. Tinidazole Tabs 14. Ofloxacin Tabs 1. Ethambutol Tabs 2. Rifampicin Caps 1. Chloroquine tabs 1Griseofulvin Tabs 2.Fluconazole Caps 3. Ketoconazole Tabs 1. Acyclovir Tabs 2. Lamivudine Tabs 3. Zidovudine Tabs 4. Stavudine Caps Aminophylline Tabs Dalbutamol Tabs Terbutaline Tabs Cetrizine Tabs Chlorpheniramine Tabs Loratadine Tabs. Studies in both acute and chronic conditions had quality scores of 3 or more on a scale of 15 in over 75% of reports see Table 33 ; . This is important, since trials of lower methodological quality 2 or less using the same validated scale as here ; have been shown to have a more favourable outcome.16. 60. Lipworth, B. J. New perspectives on inhaled drug delivery and systemic bioactivity. Thorax 1995; 50: 105-110. MHRA. Beclometasone dipropionate pressurised metered dose inhaler. Medicines and Healthcare Regulatory Agency 2006; 62. Ivax Pharmaceuticals. Qvar. Summary of Product Characteristics 2003; 63. Trinity Chiesi Pharmaceuticals Ltd. Clenil Modulite. Summary of Product Characterisitics 2006; 64. Selroos, O., Backman, R., Forsen, K. O., et al. Local side-effects during 4-year treatment with inhaled corticosteroids--a comparison between pressurized metered-dose inhalers and Turbuhaler. Allergy 1994; 49: 888-890. CMO. CFC-containing salbutamol metered dose inhalers. Letter 2003; CEM CMO 2003 9: 66. Hughes, D. A., Woodcock, A. and Walley, T. Review of therapeutically equivalent alternatives to short acting beta 2 ; adrenoceptor agonists delivered via chlorofluorocarbon-containing inhalers. Thorax 1999; 54: 1087-1092. Anon. Inhaler devices for asthma. Drug Ther.Bull. 2000; 38: 9-14. Brocklebank, D., Ram, F., Wright, J., et al. Comparison of the effectiveness of inhaler devices in asthma and chronic obstructive airways disease: a systematic review of the literature. Health Technol.Assess. 2001; 5: 1-149. Ram, F. S., Wright, J., Brocklebank, D., et al. Systematic review of clinical effectiveness of pressurised metered dose inhalers versus other hand held inhaler devices for delivering beta 2 ; agonists bronchodilators in asthma. BMJ 2001; 323: 901-905. O'Callaghan, C. and Barry, P. Spacer devices in the treatment of asthma. BMJ 1997; 314: 1061-1062. James, R. W. and Masters, I. B. Single breath versus panting technique in salbutamol delivery through a 750 mL spacing device. Pediatr.Pulmonol. 1990; 8: 263-267. Ward, M. J. Nebulisers for asthma. Thorax 1997; 52 Suppl 2: S45-S48.

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Pennsylvania state university college of medicine, hershey, pennsylvania 17033 received july 26, 200 accepted october 17, 200 address all correspondence and requests for reprints to: andrea dunaif division of endocrinology, metabolism, and molecular medicine, northwestern university feinberg school of medicine, 303 hast chicago avenue, tarry building 15– 709, chicago, illinois 60611-300 e-mail: a-dunaif northwestern this work was supported by the national institutes of health national institute of child health… you are currently viewing a preview of md consult for full access to this content, log in or start a subscription!
We also reported on our latest initiatives with the public consultations on proposed amendments to the Patented Medicines Regulations, 1994, and on our Discussion Paper on Price Increases for Patented Drugs. Our review of both Prices of existing patented series of submissions received drugs fell by 0.2% from 2003. from stakeholders is ongoing, Analysis of prices by therapeutic and next steps are scheduled class demonstrated considerfor initial discussion at the able variability in price changes. September Board meeting. The Canadian to foreign price For additional information, see comparison showed Canadian "2005 Consultations" on page 5 Ral Sureau, Vice-Chairperson prices at 91% of the median of of this publication. Further foreign prices in the seven coundevelopments on these initiatives will be tries used for price comparison purposes. published in our October NEWSletter. With the exception of 2002, Canadian prices, on average, have been 5% to 12% It is our hope that our more in-depth analysis below median foreign prices since 1995. of key indices in our 2004 Report will foster a better understanding of the current pharmaNinety four new drug products came under ceutical context as we strive to work in the the PMPRB's jurisdiction in 2004, including best interest of all Canadians. 25 new active substances. At the time of the release of this NEWSletter, 19 remained Before closing, I would like to take this under investigation. Since January 2004 to opportunity to thank my colleagues on the date, enforcement activities resulted in ten Board and Staff. As I near the end of my Voluntary Compliance Undertakings VCUs ; second and final term as Vice-Chairperson by patentees ensuring that prices of patented of the Patented Medicine Prices Review Board in October, I want to thank everyone medicines are within the Guidelines. The for their contribution to this organization. hearing into the price of the patented mediThe PMPRB plays a significant role in cine Dovobet, initiated with the release of a protecting the interests of Canadians by Notice of Hearing in November 2004, is set ensuring that prices of patented medicines to resume on September 12. are not excessive. It has been both a Patentees reported total R&D expenditures pleasure and a privilege for me to serve as of $1.17 billion in 2004, a decrease of Vice-Chairperson of the PMPRB and I wish 2% over the $1.19 billion in 2003. The you all success in your endeavours and to R&D-to-sales ratio continued its downward the organization as a whole. trend with the ratio for all patentees declining to 8.3% from 8.8% last year and Rx&D members' contribution declining to 8.5% from 9.1%. Spending on basic research increased by 23%, reaching $221.7 million, and representing 19.7% of current R&D. Ral Sureau Vice-Chairperson and alfacalcidol. Fig. 8. Development of use-dependent block after internal diffusion of control pipette solution CTRL, plain line ; , or pipette solution supplemented with 1 mM nadolol , ; , 1 mM salbutamol ; , or 300 M QX-314 F ; . The hSkM1-transfected tsA201 cells were held at 120 mV and received a 25-ms depolarizing pulse to 30 mV every 10 s to elicit INa. This protocol was applied about 5 min after achieving whole-cell configuration to allow pipette solution to diffuse well within the cell. Peak INa measured at each test pulse was normalized with respect to the first pulse INa. Each data point is the mean S.E.M. from five cells in each condition. The S.E.M. bars are omitted for CTRL, nadolol, and salbutamol to improve clarity. Melting point: salbutamol melts at approximately 155 c, with decomposition and calciferol. Ad.l. theoretical detection limit as calculated from lowest standard, recovery and dilution factors. 'c.v.1 coefficient of variation of measured samples spiked with 5 ng of salbutamollg. 'c.v.2 coefficient of variation of measured samples spiked with 25 ng of salbutamoUg. dNanograms milliliter.
RELATED ARTICLES IN ARCHIVES OF INTERNAL MEDICINE In This Issue of Archives of Internal Medicine Arch Intern Med. 2005; 165: 1454. FULL TEXT Quality: The Need for Intelligent Efforts Lawrence Baruch and Robert A. Phillips Arch Intern Med. 2005; 165: 1455-1456. EXTRACT | FULL TEXT Adherence to Heart Failure Quality-of-Care Indicators in US Hospitals: Analysis of the ADHERE Registry Gregg C. Fonarow, Clyde W. Yancy, J. Thomas Heywood, and for the ADHERE Scientific Advisory Committee, Study Group, and Investigators Arch Intern Med. 2005; 165: 1469-1477. ABSTRACT | FULL TEXT and alpha-lipoic.
Make people not want drugs, no amount of legal manoeuvring will make the problem go away. But changes in the law could do much to mitigate the damage; even if just the suggestions regarding cannabis were to be implemented, the result would be a massive release of resources to address the other issues. 1997 cough and congestion mescolor tablets and amantadine. 2. Inter jurisdictional cooperation 3. Suitable receiving and sending sites 4. Suitable Incentives for receiving site developers and sending area landowners 5. Use of Banks and Other "Market-Making" Mechanisms We analyzed the potential for a TDR program involving both the Santa Barbara Ranch MOU proposal 54 units ; and ALT 1 72 units ; pursuant to the County's Local Coastal Plan Policy 2-13, which requires the County to examine the possibility of transferring development off of Naples Townsite before approving development there. We concluded that the main program goal under Policy 2-13 appears to be moving urban development from the Santa Barbara Ranch Project to a location inside the existing urban boundary line. This analysis examines several options. First, we examine the feasibility of transferring the maximum number of building envelopes off the site, no matter where on the site they are located. Secondly, we examine the feasibility of transferring only those building envelopes within the public viewshed of Highway 101. Thirdly, we examine the feasibility of eliminating lots from the coastal bluff. We conclude that if some, but not all, the development can be transferred, the main program goal would appear to be transfers of the development envelopes that are the most visible from Highway 101. No 1 2 Drug Paracetamol Ibuprofen Sodium choride Chlorhexidine - oxybuprocaine Amoxicillin Oxomemazine - guaifenesin Co-amoxiclav Salnutamol Mefenamic acid Xylometazoline n 370 246 168 % 23.6 15.7 10.7 and amiloride.
Summary This laboratory study compares the total mass of active ingredient delivered by the LeverHaler and two devices AeroChamber and OptiHaler ; , plus a throat model. The result is a table of the average amount of drug per spray ; that would be delivered to a patient who uses the device as directed. The results are also presented in graphical form. For the MDI drug tested--Alupent--the LeverHaler delivers at least as much total active ingredient as the two devices. Method Three devices were compared, LeverHaler, AeroChamber and OptiHaler. The LeverHaler was used in ten trials n 10 ; . Ten different AeroChambers and ten different OptiHaler were used n 10 ; . Each device was used in a breathing simulation where the device was attached to a throat model and filter. The assembly was attached to a Harvard Breathing Machine, which was able to breathe through the assembly, subjecting the device to the same breathing patterns that a patient might exhibit. Any medication inhaled from the device would impact on the filter for analysis. The breathing machine was set at 5 breaths per minute and a volume of 750 mL. The MDI canister was actuated at the start of inhalation, as directed by the drug and device manufacturers. After delivery of the MDI doses, the filter was washed and analyzed by HPLC ; for dose output. For HPLC methods see the following section. For each type of device, the average and standard deviation of the ten dose output measurements was calculated. The Student t-test was used to compare dose output performance among the three types of devices. This procedure was carried out for the three drug tested Alupent, for example, salbutamol effect. Anaphylactic shock and conditions such as angioedema are medical emergencies that can result in cardiovascular collapse and or death. They require prompt treatment of possible laryngeal oedema, bronchospasm or hypotension. Atopic individuals are particularly susceptible. Insect bites and certain foods including eggs, fish, peanuts and nuts are also a risk for sensitized persons. Therapeutic substances particularly associated with anaphylaxis include blood products, vaccines, hyposensitizing allergen ; preparations, antibiotics especially penicillins ; , iron injections, heparin, and neuromuscular blocking drugs. Acetylsalicylic acid and other nonsteroidal anti-inflammatory drugs NSAIDs ; may cause bronchoconstriction in leukotriene-sensitive patients. In the case of drug allergy, anaphylaxis is more likely to occur after parenteral administration. Resuscitation facilities should always be available when injecting a drug associated with a risk of anaphylactic reactions. First-line treatment of a severe allergic reaction includes administering epinephrine adrenaline ; , keeping the airway open with assisted respiration if necessary ; , and restoring blood pressure. Epinephrine adrenaline ; should immediately be given by intramuscular injection to produce vasoconstriction and bronchodilation and injections should be repeated every 10 minutes until blood pressure and pulse have stabilized. If there is cardiovascular shock with inadequate circulation, epinephrine adrenaline ; must be given cautiously by slow intravenous injection of a dilute solution. An antihistamine such as chlorphenamine is a useful adjunctive treatment given after epinephrine adrenaline ; injection and continued for 24 to 48 hours to reduce the severity and duration of symptoms and to prevent relapse. An intravenous corticosteroid such as hydrocortisone has an onset of action that is delayed by several hours but should be given to help prevent later deterioration in severely affected patients. Further treatment of anaphylaxis may include intravenous fluids, oxygen, an intravenous vasopressor such as dopamine, intravenous aminophylline or injected or nebulized bronchodilator, such as salbutamol and amiodarone. The following medications may affect the way that salbutamol works or its effects on the body: monoamine oxidase inhibitors e, g.

Toxic dose of salbutamol

EDITORIAL BOARD Georges I. Bahsali, MD, FRCPC Department of Medicine University of Sherbrooke David A. Hanley, MD, FRCPC Department of Medicine University of Calgary Anthony B. Hodsman, MB, BS, FRCPC Department of Medicine University of Western Ontario Robert Josse, MB, BS, FRCP UK ; , FRCPC Department of Medicine University of Toronto Wojciech P. Olszynski, MD, PhD, FRCPC Department of Medicine University of Saskatchewan Kerry Siminoski, MD, FRCPC Department of Medicine and Radiology University of Alberta and cordarone.
Article #29 Author: Kizer E, Scolnik D, Macpherson A et al Title: Variables associated with medication errors in pediatric emergency medicine Journal: Pediatrics, 2002; 110; 737-742 Summary: This was a retrospective chart review of 1532 children treated at a pediatric tertiary care hospital treated during 12 randomly selected days in the summer of 2000. 2 pediatricians independently decided whether a medication error had occurred and ranked the mistake by severity. Prescribing errors were found in 10.1% 154 1532 ; of the charts with the following variables accounting for an increased incidence of errors: 1 ; Patients seen between 4A and 8A 2 ; Patients with severe disease 3 ; Medication ordered by a trainee- higher incidence at the beginning of the academic year 4 ; Patients seen on weekends The most common drugs involved in errors were: APAP, antibiotics, asthma medications and antihistamines. There were 2 severe errors drug error that could cause death or that was ordered was not given to a child with meningitis, and morphine ordered every 30 minutes for a child with a Supracondylar fracture; 47.5% of errors were ranked as significant drug error that could cause a non-lifethreatening consequence or less effective treatment, e.g.- 10 fold lower dose of amoxicillin for AOM, albuterol inhaler ordered as 2 puffs every 1 hour, wrong cefuroxime dosing regimen ; 51.5% were insignificant or minimal risk errors e.g. 24mg of dimenhydrinate instead of 20mg, dose for ealbutamol not specified.
During the Type A interview, all patients were seated in a recliner chair in a comfortable isolated laboratory. All data recording was done in a separate, adjacent room. BP was measured every minute by an ultrasonic Doppler device 28 ; , while heart rate HR ; was recorded continuously and averaged every minute 29 ; . Increases of BP and HR from resting baseline were calculated as average values during the interviews minus average values during baseline, and will be denoted by ASBP, ADBP, and AHR respectively. All the Type A interviews were The following is a report of the results tape-recorded and scored by two trained co-workers of a pilot study in hypertensive patients who had no knowledge of the patient's BP or treatment status, or whether they were reviewing the first who were given either beta blockers or a or second patient interview. Inter-rater reliability of diuretic. Physiological data and Type A the behavioral assessments were 90% for the A B behavior patterns were compared before classification and 70% for the stylistics. For statistiand after treatment. Patients receiving dical evaluation, Pearson correlation coefficients, X tests, and Student's t tests were used. If not indicated uretics served as the control group. otherwise, means and standard deviations are reported. The two treatment groups did not differ in age Group 1: 47, 9 Group 2: 46.7 11 years ; , causal METHODS BP at rest Group 1: 153.0 94.1 Group 2: Nineteen patients with mild hypertension and a 145.7 88.7 10 mmHg ; or HR Group 1: 69.0 10; mean age of 47 years were randomly divided into Group 2: 69.8 10 bpm ; before therapy, nor in BP two groups: Group One was treated with beta blockafter therapy Group 1 137.0 82.7 Group 2: ing agents; Group Two was treated with diuretics. 134.7 87.3 10 mmHg ; . HR was decreased after treatment in those patients receiving beta blocking All the patients were white males, essential hypertensives, and without target organ damage. All un- agents Group 1: 51.7 5; Group 2: 68.3 10 bpm; t 3.2, p 0.005 ; . derwent intensive clinical investigation in order to and elavil. Figure 2. LogPD20 LogPD20FEV1 Methacholine; mean SD ; during methacholine challenge test protected by placebo and salbbutamol inhaled by pMDI, pMDI spacer, and Autohaler, in subjects with correct pMDI inhalation technique n 13; black bars ; and in subjects with incorrect pMDI inhalation technique n 5; dashed bars ; . * p 0.05 between placebo and other groups by Friedman test. Found during the APO period in 3 of these ; . The mean firing rate of the TCs was 44.0 5.9 Hz, which was significantly higher than that found during the APO period and the same as the mean TC firing rate of the pre-APO period P 0.05, ANOVA ; . GPI. Before the administration of APO, 14% 13 93 ; of all GPi neurons examined displayed tremor-related activity. These cells were located in four patients 3 of whom had a pronounced limb tremor at the start of the procedure ; . The average firing rate of the TCs was 84.5 7.3 Hz and was significantly higher than the firing rate of the nonoscillatory GPi neurons in these four patients 65.3 3.1 Hz, n 54 cells, P 0.01 ; . There were no GPi TCs encountered that also had a highfrequency oscillation component see Fig. 5B ; . Only two GPi neurons with a high-frequency oscillation 10 Hz oscillation ; were encountered in all six patients. The distribution of oscillatory frequencies of GPi neurons sampled during pre-APO period, APO period, and post-APO period is shown in Fig. 5B. There were no TCs encountered in the GPi during the APO period 51 neurons examined in the 6 patients ; . During the post-APO period 22.6% 12 53 ; of the neurons were TCs. These neurons were located in the same four patients who displayed TC activity before the administration of APO. The firing rate of the 12 TCs was 96.0 8.9 Hz. This was significantly higher than the firing rate of nonoscillatory cells found in this group of four patients 78.8 4.5 Hz, n 37, P 0.05 ; . Population analysis; receptive fields STN. The proportion of neurons that responded to movements about one, two, or more joints or had no detectable RFs i.e., no response ; are displayed in Fig. 6A. The administration of APO was found to decrease the proportion of cells that had a response to limb movement from 56 to 25% and decrease the proportion that responded to two joints from 13 to 7% P 0.05, 2 8.31, n 150 ; . There were no neurons with multiple or bilateral RFs found during the APO period. During the post-APO period, the proportion of cells with no detectable RFs decreased to 52% n 14 ; . The relative proportions of single RFs to double and multiple RFs did not significantly change in either the APO period or the post-APO period P 0.71, 2 0.66, n 74 ; . When the average firing rates, bursting, or oscillatory patterns were compared between groups of cells that had no response, single, double, or multiple RFs, no significant differences were evident, and APO did not preferentially affect any of these groups. GPI. The proportions of neurons that had no detectable RF and those that responded to movements about one, two, or more joints are displayed in Fig. 6B. The administration of APO decreased the proportion of cells that responded to limb movement from 54 to 20% P 0.01, 2 9.43, n 102 ; . APO decreased the proportion of cells that responded to passive movement of two joints from 10 to 4%. During the APO period, there were no neurons with a multiple or bilateral RF encountered. The relative proportions of single RFs to double and multiple RFs did not significantly change during this period or during the post-APO period P 0.11, 2 4.50, n 46 ; . There were no significant differences between firing rates, bursting, or oscillatory behavior of cells that did not have a detectable RF and those that did have detectable RFs nor was and endep and salbutamol, because salbuatmol nebuliser solution. LU MC NL 08.03.2000 GB 1998 001491 22.05.1998 WO 1998 052909 1998 GB 9710728 HERSTELLUNG VON TRI-IODO-BENZOLVERBINDUNGEN PREPARATION OF TRI-IODO BENZENE COMPOUNDS PREPARATION DE COMPOSES BENZENIQUES TRI-IODES 73 ; Amersham Health AS, Nycoveien 1-2, PO Box 4220, Nydalen, 0401 Oslo, NO 72 ; THIELKING, William Henry, Averill Park, 12018 NY, US INGVOLDSTAD, Einar Odd, N-4510 Spangereid, NO GULBRANDSEN, Trygve, N-1352 Kolsas, NO 74 ; Wichmann, Hendrik, et al, Patentanwalte Isenbruck Bosl Horschler Wichmann Huhn Postfach 86 08 80, Munchen, DE. 30d wholesale cost generic if available ; + professional fee, min-max dosing where applicable except SABA salbutamol pMDI 200mcg od equivalent ; and theophylline ~400mg d inh sol inhalation solution nebule; pMDI pressurized metered-dose inhaler; Drug use in pregnancy: B either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women, OR animal-reproduction studies have shown an adverse effect other than a decrease in fertility ; that was not confirmed in controlled studies in women in the first trimester and there is no evidence of a risk in later trimesters C either studies in animals have revealed adverse effects on the fetus and there are no controlled studies in women, OR studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus; D there is potential evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable 18 despite the risk eg. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective ; . m subscript denotes that the warning is from the manufacturer. Compiled by: Anne Nguyen PharmD; Reviewed by: Rajesh Mainra MD respirologist ; , Victoria Cox PharmD March 2004 and caduet!
References britton earnshaw, and palmer, 1992 ; a twelve month comparison of salmeterol with salbutamol in asthmatic patients.

Liquid lanolin eye ointment Magnesium sulphate Mannitol Methylene blue Metoclopramide Oxytocin Phenobarbital syn. phenobarbitone ; Protamine sulfate Salbutamll Tranexamic acid Verapamil Vitamin K1.

Figure 2. Individual intrinsic positive endexpiratory pressure PEEPi ; values at four study time points. As in Table 1, patient numbers correspond to the order of enrollment in the study. The continuous decline of PEEPi along the four time points is evident in all patients. At PEEPe-S, PEEPi is practically abolished in four patients patients 1, 2, 7, and 10 ; . PEEPi values at the ZEEP-II time point see also Methods and Tables 2 and 3 ; are not presented because at ZEEP-II, PEEPi values were virtually identical to values at ZEEP-I. PEEP positive end-expiratory pressure; ZEEP zero PEEP ZEEP-I time point; see also Methods and Tables 2 and 3 S salbutamol; PEEPe external PEEP. Taking asthma medications in the form of pills makes me concerned because they contain higher amounts of cortisone than the inhaled ones and that is not good for your body, for example, salbutamol effect. The activities of the Bone and Mineral Service are underpinned by an integrated approach to research, teaching and patient care. High-profile publications have been produced in several areas: the impact of pregnancy and lactation on bone health, twin studies of the effects of nutritional indices on bone, and a major review of vitamin D analogues and alfacalcidol.
O Salb7tamol 100 mcg puff MDI 2 puffs o qid o q4h while awake & o q1h prn o Ipratropium 20 mcg puff MDI o 2 puffs o qid o q4h while awake o 4 puffs o Combivent o 2 puffs o 4 puffs o qid or o q4h while awake o Salmeterol Serevent ; 25 mcg puff 2 bid o Formoterol Oxeze ; 12 mcg 1 bid o Tiotropium Spiriva ; 18 mcg daily - May continue to use own o Other o Ipratropium 0.5 mg salbutamol 2.5 mg q4h o Ipratropium 0.25 mg q4h o Ipratropium 0.5 mg q4h o Salbuttamol 2.5 mg q4h o Salbutamol 5 mg q4h.

Chairman of the IRB TUEC Huguenot House 35-38 Stephens Green Dublin 2 Ireland All TUE Application Forms should be typed or completed in BLOCK LETTERS and where possible translated into English, French or Spanish, which are the three official languages of the IRB. A standard TUE application must be supported by relevant medical records reports and be submitted to the Player's national Union who will forward the application onto the IRB TUEC. A standard TUE application will not be accepted if an International Level Player submits the standard TUE application directly to the IRB TUEC save in an emergency situations. Where possible the Chief Medical Officer Doctor of the Player's national Union should be notified of the standard TUE application to the IRB TUEC. When appropriate, the application should include a statement by the Chief Medical Officer Doctor of the Player's national Union attesting the necessity of the otherwise Prohibited Substance or Prohibited Method in the treatment of the Player. 23. How should an abbreviated TUE application for an International Level Player be submitted to the IRB TUEC? A duly completed abbreviated TUE application form is all that is required to be submitted to the IRB TUEC. The IRB TUEC may request further information on the abbreviated TUE as and when it considers necessary and may initiate a review at any time during the duration of the TUE. The International Standard for TUEs provides that a TUE may be cancelled by the TUEC at any time. The application must be sent via the Player's national Union who will then forward the application to the IRB TUEC via fax to a confidential fax number in Ireland + 353 1 2409 or scanned in electronic `pdf' format and sent to TUE irb . The original application form is not to be sent by post or courier unless requested by the IRB TUEC. 24. How should a standard TUE application for all other Players be submitted to the appointed NADO TUEC in the country of the Player's national Union? Each Member Union should contact the appointed NADO TUEC established in the country of the Union to determine the appropriate fax numbers and methods by which both abbreviated and standard TUE applications can be submitted for non International Level Players. All non International Level Players applying for a standard TUE must submit their TUE applications to their national Union who will forward the application to appointed NADO TUEC. A standard TUE application must be supported by relevant medical records reports. The circumstances regarding an emergency TUE application should be checked with the NADO TUEC. Where possible the Chief Medical Officer Doctor of the Player's national Union should be notified of the standard TUE application to the NADO TUEC. When appropriate, the application should include a statement by the Chief Medical Officer Doctor of the Player's national Union attesting the necessity of the otherwise Prohibited Substance or Prohibited Method in the treatment of the Player. 25. How should an abbreviated TUE application for all other Players be submitted to the appointed NADO TUEC in the country of the Player's national Union? The International Standard for TUEs provides that a duly completed abbreviated TUE application form is all that is required to be submitted to the appointed NADO TUEC in the country of the Player's national Union. An abbreviated TUE application must be sent via the Player's national Union who will then forward the application to the NADO TUEC via the appropriate method.

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