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Symptom of the breast without any specific physiological or pathological abnormality in the parenchyma or stroma of the organ.1 It is the most common clinical complaint in patients with benign breast disease. Approximately 66% of healthy working women have mastalgia.2 Based on its natural history and its response to medication, mastalgia is classified as cyclical mastalgia, noncyclical mastalgia, or chest wall pain.3 In addition, mastalgia that disturbs a patient's normal life, such as sleeping, working, and sex, can also be classified according to severity as mild, moderate, or severe. Only 5% to 20% of patients with moderate to severe mastalgia need medications, 4, 5 whereas those with mild mastalgia can be treated with psychotherapy or diet control.6 Although the treatment for mastalgia already has been studied extensively, highly effective therapies are still lacking. Presently available drugs prescribed, for instance, albuterol manufacturer. Home drug prices order status faq contact us browse alphabetically for your drugs a b c generic for combivent 200 metered doses side effects side affect of generic for combivent ipratropium bromide & albuterol salbutamol generic combivent is a bronchodilator used to treat asthma and chronic obstructive pulmonary disease. There are accumulating data showing that antibiotic resistance increases mortality and morbidity from nosocomial infections. It also adds substantially to hospital cost by increasing length of stay and other resources utilization Kollef, G et al. 1999; Kollef, Ward et al. 2000; Niederman 2001 ; . The total costs associated with antibiotics is not only related to resistance but also to multiple sources such as co-medication and adverse drug events Birmingham, Hassett et al. 1997 ; . Adverse drug reactions ADR ; , according to the WHO definition, is any noxious unintended, and undesired effects of a drug, that occurs at doses used in humans for prophylaxis, diagnosis, or therapy. Both ADR and medication errors are included in the definition of Adverse Drug Events Bates 1995 ; . The incidence of ADR varies greatly 1, 530% ; depending on the method used to detect them chart review, computer monitoring or spontaneous reporting ; Bates, Miller et al. 1999; Cullen, Bates et al. 2000 ; . In a meta-analysis, incidence of adverse drug reactions, including non-serious and serious events was 10.9% CI 7, 9-13, 9% ; of hospitalized patients. Factors possibly influencing the incidence have been identified: average length of stay, age, gender, renal function, hepatic function and drug exposure Lazarou, Pomeranz et al. 1998; Leape, Cullen et al. 1999; Cullen, Bates et al. 2000 ; . Cullen et al., whose study dealt with adverse drug events rather than only drug reactions, found that, although ICU patients had a significantly higher rates of potential ADE than non-ICU patients, after adjusting for the number of drugs administered, the rate was similar in both sectors. No class of drugs was responsible for a disproportionate share of ADE in their study. However, Bordet et al. showed that cardiovascular drugs and contrast media accounted for 36% and 26% of the ADR while drugs affecting blood clotting and antibiotics were the cause of 13% and 14% of adverse drug reactions respectively Bordet, Gautier et al. 2001 ; . Similarly, in Darchy's report, the drugs implicated in iatrogenic disease remains standard; cardiovascular drugs accounted for 31%, anti-inflammatory and analgesics for 20% and antibiotics for 11% Darchy, Le Miere et al. 1999 ; . In his study, Classen states that, although adverse events seem to occur in a small proportion of antibiotic courses, the frequency of antibiotic use makes them account for 23% of all adverse events recorded Classen, Pestotnik et al. 1997; Avorn and Solomon 2000 ; . 10, for example, albuterol inhaler online.
In a study of patient outcomes and the financial consequences of migraine treatment, patients were compared six months before and six months after initiation of specific antimigraine therapy.3 After six months of treatment, the mean number of migraine-related physician office visits, emergency department visits, and medical procedures significantly decreased. Health-related quality-of-life and physical component scores significantly improved, as did patient satisfaction 64% versus 42% ; . Time lost from workplace productivity and nonworkplace activity were significantly decreased by 53% and 44%, respectively ; . In addition to migraine-specific medications, the U.S. Headache Consortium endorses behavioral and cognitive techniques such as biofeedback, deep breathing exercises, and meditation. This program targets physicians, pharmacists, and other health care practitioners interested in the management of dyslipidemia and alesse.
CAREC and the University of the West Indies, Mona, have recently initiated a project on The Threat of Dengue Fever: Assessment of Impacts and Adaptation to Climate Change in Human Health in the Caribbean. This project is to be executed in all CAREC member countries to demonstrate whether there is firm evidence of a relationship between peaks in dengue occurrence and increases in air temperature, some of which occur in El Nino years. The three year project will be coordinated under two project coordinators: Prof Tony Chen, Atomospheric Physicist and Climatologist at the UWI Mona Campus, Jamaica, and Dr Sam Rawlins, Entomologist at CAREC. The climate database for all participating countries will be constructed at Mona, while the epidemiological retrospective and prospective disease data and vector data will be gathered from all countries and CAREC. Data analysis including the use of geographical information systems will be performed at both Centres. Socio-economic data gathered during the course of the study will help to provide information for adaptation strategies such as the usefulness of early warning systems for the Caribbean community. A ACCUZYME.13 ACEON .10 acetaminophen codeine .8 acetasol-HC.14 acetazolamide.19 acetohexamide .15 ACTIVELLA.17 ACTONEL.17 ACTONEL 30MG .13 ACTOS .15 ACULAR.19 adrenalin chloride .20 ADVAIR DISKUS.21 AGGRENOX.11 albuterol for nebulization.20 albuterol inhaler.20 albuterol sulfate.21 ALLEGRA .20 ALLEGRA D .20 allopurinol .17 ALPHAGAN P.19 ALTACE .10 ALTOPREV.11 AMBIEN .9 aminocaproic acid.11 amitriptyline HCl .9 amoxicillin .6 anagrelide hydrochloride .13 ANDRODERM .15 ANDROGEL .15 ANTARA.11 antipyrine w benzocaine.14 ARANESP.16 ARAVA.17 ARICEPT .8 AROMASIN.7 ATACAND .10 ATACAND HCT .10 AUGMENTIN XR .6 AVALIDE .10 AVANDIA .15 AVAPRO.10 AVELOX .6 AVODART.21 AZOPT .19 B baclofen .8 betamethasone valerate.12, 13 BETASERON.16 bethanechol chloride .21 23 BETOPTIC S.18 BIAXIN XL .5 BICNU .7 bleomycin sulfate.7 BLEPHAMIDE .19 buproban.13 bupropion HCl.9 buspirone HCl .9 butorphanol tartrate .8 BYETTA.14 C CADUET.11 CANASA.16 captopril .10 CARAC .12 carbidopa levodopa.8 carboplatin .7 CASODEX .7 CAVERJECT.21 cefaclor.5 cefadroxil .5 CEFTAZIDIME.5 cefuroxime axetil .5 CELEBREX .9 CELLCEPT .7 CENESTIN.17 cephalexin.5 CERVIDIL.17 chlorpromazine HCl .9 choline magnesium trisalicylate.9 CIALIS .21 cilostazol.11 CILOXAN .18 CIPRODEX .14 ciprofloxacin HCl .6, 18 cisplatin .7 citalopram hbr.9 CLARINEX.20 CLARINEX SYRUP.20 clarithromycin .5 CLEOCIN.17 CLEOCIN PALMITATE .5 clindamycin phosphate .12 clonidine HCl .10 clotrimazole .5 colchicine.17 COLESTID.11 colytrol.15 COMBIVIR .5 COPAXONE.8 COREG .10 and allegra.

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Best of British An Initial Collection of Chemistry Based Companies Professor SV Ley FRS CBE & Dr AD Morris Introduction As a part of the Innovation Group of the Chemistry Leadership Council, I was asked to put together some success stories where the UK has led or taken a distinct position bringing innovative chemical technologies and applications to the business forum and to global market places. In the UK, chemistry has both a strong academic and industrial heritage. Many new and important chemical methods for synthesis and manufacturing have been pioneered here and innovative applications of chemistry have been developed advancing our understanding of biological systems and creating technological improvements. Our chemistry is particularly strong in the pharmaceutical sector where the UK has produced several landmark, popular treatments and has pioneered new drug discovery methods. Leading examples of success in this sector include: in 1964 bringing to market the revolutionary angina treatment and beta blocker, propranolol ICI Pharmaceuticals in 1969 bringing to market the popular asthma treatment Ventolin albuterol ; Glaxo in 1972 the discovery of the semisynthetic antibiotic Amoxicillin Beecham ; which paved the way to the anti-infective Augmentin, an amoxicillin clavulanate potassium mixture, which continues to be in the global top 20 drugs by sales value; in 1976 bringing to market the first gastric acid blocker Cimetidine Smith Kline and French ; , which in turn gave way to the two blockbuster anti-ulcer drugs Zantac Smith Kline and French ; and Tagamet Glaxo in 1981 bringing to market the top antiviral Zovirax Wellcome in 1991 bringing to market the novel migraine therapy Imigran sumatriptan ; Glaxo and in 1998 bringing to market a novel therapy for erectile dysfunction, Viagra Pfizer ; . Other leading drugs and therapies discovered in the UK include for example: the anticancer agents Arimidex, Casodex, Nolvadex Tamoxifen ; , Tomudex and Zoladex, and the current leading intra venous anaesthetic Diprivan, all from AstraZeneca at Alderley Park; the anti-hypertensive, Cardura, the cardiovascular therapy, Norvasc and the antifungal, Diflucan, all from Pfizer UK; and the migraine therapy, Maxalt, discovered at Merck UK. With respect to 2002 global drug sales, Norvasc is the UK's most successful product with sales at approximately $4 billion. In terms of new drug discovery technologies some recent examples of highly successful companies include the chiral-tools based company, Chiroscience, acquired by Celltech, the chemical services company, Oxford Asymmetry, acquired by Evotec and the combinatorial chemistry company, Cambridge Discovery Chemistry, acquired by Millennium Pharmaceuticals. Argenta, a corporate spinout from Aventis is also making significant advances in combinatorial techniques for drug discovery. In this document an initial selection of success stories are presented where the UK is capitalising on creative chemistry for innovative processes and products in global markets. In this selection, areas of expertise in chemistry are wide-ranging including chiral technologies, bacteriophage display and x-ray crystallography for new drug discovery; ionic liquids, flow reactors and supercritical fluid facilities for environmentally benign chemical manufacturing; photochromic dyes and light emitting polymers for the display industry. Was subject to competition from brand or generic forms of albuterol sulfate since the beginning of the class period and allopurinol. 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Or is it because some patients respond to the If your asthma seems to worsen after long-acting beta-agonist bronchodilators difstarting a long-acting beta-agonist bronferently than most? Evidence indicates that chodilator, notify your asthma care prowe are born with genetic differences in the vider. receptor molecule the beta receptor ; to which salmeterol binds in the airway wall. Some of us If you are taking a long-acting beta agomay have a beta receptor which, when stimunist and suffer an asthmatic exacerbalated with salmeterol, causes worsened lung tion that does not respond normally to function rather than bronchodilation. Still quick-relief treatments, seek medical care other possibilities exist: might in some patients promptly and notify your asthma care the long-acting beta-agonist bronchodilators provider. prevent the quick-acting bronchodilators, like albuterol, from working? Or are there effects of the long-acting beta-agonists unique to some people -- that we simply have not Editor-in-chief Christopher H. Fanta, M. D. yet identified? Breath of Fresh Air is published quarterly by the Partners Asthma Center, We do know the following. For 75 Francis Street, Boston, MA 0115. We gratefully acknowledge Glaxo Smith most people, Advair improves Kline for their generous contribution toward publication of this newsletter. lung function, prevents asthmatic 006 Partners Asthma Center. attacks, and improves their quality Requests for permission to reprint should be addressed to the above. of life. We know that deaths from Telephone: 617 ; 73-4353 Fax: 617 ; 73-741 asthma are very rare, and they Internet: : asthma.partners have not risen significantly since E-mail: asthma partners.

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Oral medications a medication that is taken orally is carried throughout the bloodstream to all of the body's systems; thus, it is a systemic treatment and alprazolam. Different hormones. There are several different estrogens and several different progestin compounds which might be in the particular brand of pill. Avery detailed patient history is imperative before the MD will prescribe a particular kind of pill. The nurse must always be alert to the patient historical information; to help make the decision for which brand is best for the patient. Most combination contraceptives will begin on the first Sunday after the menses. Take one pill daily, at the same time each day. If 21-day packs are used, wait a week to start the next pack. If 28-day packs are used, no wait is necessary. The woman should be advised to still use another form of contraception during the first month, because protection will not be built up enough. Minipills are started on the first day of menstruation. Then take one pill daily, every day, at the same time every day. Missed pills should be taken as soon as possible. If you miss more than one pill, make up the difference as instructed. If any of the pills are missed, you should use an additional form of contraception until your next pack begins, or next period. Always consult MD for missed pills, and instruct the patient to report any adverse symptoms. Other Considerations: A complete physical exam and gynecological workup are performed before prescribing the drugs. Pills should be discontinued two weeks before elective surgery in order to decrease the incidence of thrombosis post-surgery. Serum cholesterol may be elevated or decreased in some women. Glucose intolerances have been noted in some. Increases in circulating thyroxine, proteins, PBI and T4 have been noted. Many other hematology results can be affected, including coagulation studies and blood plasma components. The drugs may interact with other drugs, always check if patient is taking other meds, for instance, aerosol albuterol.

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You are in: emedicine specialties ophthalmology metabolic disorders rate this article email to a colleague synonyms and related keywords: uric acid, urate crystals, ocular tissue, kidneys, kidney stones, urinary collecting system, joint inflammation, tophus, tophi, alcohol, uric acid salts author information author information introduction clinical differentials workup treatment medication follow-up miscellaneous bibliography andrew a dahl, md, is a member of the following medical societies: alpha omega alpha , american academy of ophthalmology , american college of surgeons , american medical association , american society of cataract and refractive surgery , and wilderness medical society editor s ; : richard w allinson, md , associate professor, division of ophthalmology, texas a&m university health science center, associate professor, department of surgery, scott and white clinic; francisco talavera, pharmd, phd , senior pharmacy editor, emedicine; r christopher walton, md , director of uveitis and ocular inflammatory diseases service, associate professor, department of ophthalmology, university of tennessee college of medicine; lance l brown, od, md , ophthalmologist, regional eye center, affiliated with freeman hospital and st john's hospital, joplin, missouri; and hampton roy, sr, md , associate clinical professor, department of ophthalmology, university of arkansas for medical sciences disclosure introduction author information introduction clinical differentials workup treatment medication follow-up miscellaneous bibliography background: drink wine, and have the gout; drink none, and have the gout and altace. A second 12-week, randomized, double-blind trial evaluated the effectiveness of switching subjects from cfc 11 12-propelled albuteol to ventolin hfa. 8. How long can I live on an artificial kidney? Patients have lived many years on dialysis. Some of the first patients treated by dialysis in the early 1960s are still living. How long you live depends on how carefully you follow the treatment program prescribed for you, and your overall medical condition and amaryl.

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And increased coronary blood flow Nayler and Mclnnes, 1972 ; . In the present study, slight reductions in indirect systolic blood pressures measured over the tail occurred on occasion in addition to tachycardia data not shown ; . Dogs which received 2 0.5 times the human daily dose of albuterl also exhibited T wave changes in chest leads rV2 and V| 0 . The reversal of polarity of T waves observed is considered a secondary effect of the hypokalemia Detweiler, 1981 ; and occurred simultaneously with reductions in serum potassium. Hypokalemia is believed to occur due to the stimulation of skeletal muscle Na-K-ATPase, re. Canada's and mexico's lower drug costs have been well covered in the media of late and ambien. All i take is theophylline- i love theophylline, albuterol and singulair.

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1. COMBIVENT Inhalation Aerosol Study Group. In chronic obstructive pulmonary disease, a combination of ipratropium and albuterol is more effective than either agent alone. An 85-day multicenter trial. Chest. 1994; 105: 1411-9. [PMID: 8181328] 2. COMBIVENT Inhalation Solution Study Group. Routine nebulized ipratropium and albuterol together are better than either alone in COPD. Chest. 1997; 112: 151421. [PMID: 9404747] 3. National Heart, Lung and Blood Institute. Global Initiative for Chronic Obstructive Lung Disease: Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease NHLBI WHO workshop report ; . Bethesda, MD: National Heart, Lung and Blood Institute; 2001. 4. O'Donnell DE, Aaron S, Bourbeau J, Hernandez P, Marciniuk D, Balter M, et al. State of the Art Compendium: Canadian Thoracic Society recommendations for the management of chronic obstructive pulmonary disease. Can Respir J. 2004; 11 Suppl B: 7B-59B. [PMID: 15340581] 5. Anthonisen NR, Connett JE, Kiley JP, Altose MD, Bailey WC, Buist AS, et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. JAMA. 1994; 272: 1497505. [PMID: 7966841] 6. Sin DD, McAlister FA, Man SF, Anthonisen NR. Contemporary management of chronic obstructive pulmonary disease: scientific review. JAMA. 2003; 290: 2301-12. [PMID: 14600189] 7. Wilt TJ, Niewoehner D, Kim C, Kane RL, Linabery A, Tacklind J, et al. Use of Spirometry for Case Finding, Diagnosis, and Management of Chronic Obstructive Pulmonary Disease COPD ; . Evidence Report Technology Assessment No. 121 AHRQ Publication No. 05-E017-2. Rockville, MD: Agency for Healthcare Research and Quality; 2005.

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Clear communication with the student, parents, teachers and school nurses is central to managing EIB or Sports Asthma at school. The Asthma Center specialists recommend the following: Pretreatment prophylactic treatment ; with asthma medications including short acting bronchodilators Proventil, Ventolin, Maxair, TM albuterol, Combivent, DuoNebTM and Xopenex ; and or cromolyn sodium Intal ; at least 15 - 30 minutes prior to exercise 1 hour prior to exercise may be optimal ; . Alternatively, a long acting bronchodilator Serevent, Foradil ; administered in the morning may provide adequate EIB relief throughout the day. Pretreatment with leukotriene modifiers Singulair, Accolate ; and or theophylline preparations may also be beneficial if control of EIB is not adequate with short acting bronchodilators and or cromolyn sodium medications alone. A combination of medications may be necessary to achieve adequate control of EIB. Regular maintenance treatment of asthma with daily controller medication, such as inhaled corticosteroids, long acting bronchodilators and other controller agents, may be necessary if adequate control of EIB is not achieved with exercise pretreatment alone. If a student has been diagnosed with asthma and has some chest symptoms even when not exercising, maintaining optimum treatment throughout the year is very important in minimizing EIB or Sports Asthma. Performing warm-up exercises before and cool down exercises after exertion can help prevent EIB or Sports Asthma or modify its severity. Following each episode of EIB or Sports Asthma, a refractory symptom-free ; period begins within 30 minutes and can last 90 minutes where little or no bronchospasm can be induced even if rechallenged with vigorous exercise. Athletes often take advantage of this fact by warming up vigorously in order to induce a refractory period prior to competition. A micro biochemical method Neuhoff, 1971; Osborne et al., 1971 ; was used to study the amine and amino acid contents in two specific types of giant cells in the snail Helix pomatia. One type of cell GSC ; is known to contain 5-hydroxytryptamine serotonin ; Cottrell & Osborne, 1970 ; , whereas the other type of neuron lacks this amine see Briel et al., 1971 ; . Cell extracts were treated with dansyl chloride, and the dansylated substances were separated on 3 cm polyamide layers. The patterns of amino acids in both were similar. However, the buccal neurons contained significantly more methionine and glycine but less ornithine than the GSC neurons, where the presence of 5-hydroxytryptamine was confirmed and the two additional substances 5-hydroxytryptophan and 5-hydroxyindole were detected. Analysis of the 5-hydroxytryptamine-containing Retzius cells Rude et al., 1969 ; of the leech Hirudo medicinalis showed that these cells, like the GSC neurons, contained large amounts of glycine and alanine, although they differ in having higher amounts of 5-hydroxytryptamine, tryptophan, 5-hydroxytryptophan and glutamate. When 5-hydroxy[14C]tryptophan was perfused through the snail's central ganglia only the GSC.

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Acetanilide Melting Point Standard 500 mg ; Approximately 114 degrees ; Acetazolamide 2 g ; Glacial Acetic Acid 1.5 mL ampule; 3 ampules ; AS ; Acetohexamide 250 mg ; Acetohydroxamic Acid 200 mg ; Acetone 1.5 mL ampule; 3 ampules ; Acetophenazine Maleate 200 mg ; Acetylcholine Chloride 200 mg ; Acetylcysteine 200 mg ; Acetyltributyl Citrate 500 mg ; Acetyltriethyl Citrate 500 mg ; Acitretin 200 mg ; Acitretin Related Compound A 20 mg ; 2Z, 4E, 6E, ; -9- 4-methoxy-2, 3, 6-trimethylphenyl ; -3, 7-dimethylnona-2, 4, 6, acid ; Acitretin Related Compound B 20 mg ; ethyl all-E ; -9- 4-methoxy-2, 3, 6-trimethylphenyl ; -3, 7dimethylnona-2, 4, 6, ; Acyclovir 300 mg ; Acyclovir Related Compound A 50 mg ; AS ; 2[ 2-amino-6-oxo-1, 6-dihydro-9H-purin-9-yl ; methoxy]ethyl acetate ; Ademetionine Disulfate Tosylate 500 mg ; Adenine 200 mg ; Adenosine 200 mg ; Adipic Acid 100 mg ; Agigenin 25 mg ; Agnuside 25 mg ; Beta Alanine 100 mg ; L-Alanine 200 mg ; Albendazole 200 mg ; Albu6erol 200 mg ; Apbuterol Sulfate 200 mg ; Alclometasone Dipropionate 300 mg ; Alcohol 1.2 mL ampule; 5 ampules.

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That not all levels of severity have necessarily been assessed in such a way as to confirm equivalency in all situations. For this reason, the previous two guidelines recommended intravenous corticosteroids for those who were too breathless, intubated or unable to tolerate oral medications vomiting, dehydration ; . There is no evidence that this recommendation should be changed, but it should be emphasized that if patients have severe asthma, are unresponsive to treatment or there is any suspicion that oral medications will not be absorbed, the intravenous route for corticosteroids is advised. The use of magnesium sulfate in unresponsive acute asthma has gained further support since the 1999 guidelines. There have been a number of systematic reviews 15, 27 ; that have concluded that intravenous magnesium is not only safe but also effective in those patients with severe disease. It is important to appreciate that there is no support for the routine use of this agent in the emergency management of acute asthma. The emphasis is still on the appropriate use of inhaled beta-agonists, inhaled anticholinergics and systemic corticosteroids, all guided by objective measures of oxygenation, airway obstruction and clinical status. Patients with clinically severe asthma, or in whom pulmonary function is less than 30% predicted in adults and less than 50% in children, and who exhibit a poor response to appropriately titrated bronchodilator therapy incremental administration by MDI every 30 to 60 puffs, three doses every 20 min or continuous nebulization ; may benefit from intravenous magnesium sulfate. This agent has been shown to be easy to use, extremely safe and inexpensive. There is new evidence regarding the use of inhaled corticosteroids in the acute setting for patients with acute asthma 7-12, 14 ; . A recently published systematic review 8 ; suggests that inhaled corticosteroids, when used in conjunction with systemic corticosteroids, may reduce admissions to hospital and improve pulmonary function. However, a recent study 7 ; illustrates that there may be some problems in comparing oral with inhaled corticosteroids for acute asthma. In the study, patients were randomly assigned to receive, in a doubleblind fashion, inhaled corticosteroids or oral corticosteroids in addition to beta2-agonist therapy. The oral corticosteroid group performed better and was admitted to hospital less frequently. Combined with the meta-analysis, these results suggest that inhaled corticosteroids may be useful as an adjunct to systemic corticosteroids but not as a replacement choice 6 ; . Other agents, such as aminophylline and helium-oxygen, have been shown to be of limited value 16, 17 ; . In addition, evidence for or against the use of new agents, such as leukotriene modifiers and levalbuterol, is unclear at this point. Current research should help to clarify the place of these agents before the next revision of the guidelines. Treatment after discharge Several studies in children and adults have been performed, identifying several factors associated with relapse after discharge 28, 29 ; . However, most of the studies simply confirm the recommendations provided in the previous Canadian Association of Emergency Physicians Canadian.

Albuterol and flovent are the general, daily treatments, though we'll go through more intense treatments with steroids and the like at least once or twice per kid each year. View isi citation publication history issue online: 17 dec 2006 home list of issues table of contents article abstract annals of the new york academy of sciences volume 522 calcium antagonists: pharmacology and clinical research page 312-327, march 1988 to cite this article: godfraind 1988 ; calcium channels in smooth muscle a annals of the new york academy of sciences 522 1 ; , 312– 32 doi: 1 1111 j 49-663 198 tb3337 x prev article next article welcome to blackwell synergy - the source of highly cited peer-reviewed society journals from blackwell publishing you are attempting to access the pdf of this article.

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