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Obesity, Race, and Cancer Recurrence after Radical Prostatectomy. This important study sponsored by the Department of Defense Center for Prostate Disease Research CPDR ; analyzed the impact of obesity, race and pathological outcome on the probability of cancer recurrence after radical prostatectomy. The researchers drew upon the CPDR database for patient data from 1987 to 2002. They used the Body Mass Index BMI ; to categorize patients into three separate groups: obese, overweight, and normal. They found that obese men had a higher grade, more aggressive form of the disease, and higher recurrence rates after surgery. African American men were more likely to have more aggressive tumors and higher recurrence rates, and were more likely to be in the obese category. According to the authors, the study suggests that body mass may have some role in the racial disparity in tumor behavior. Source: J Clin Oncol: February 2004 via CPDR Information Release ; Of Mice and Men. A low-fat diet without caloric restriction significantly delays prostate disease progression in mice treated with androgen deprivation. Researchers at UCLA had earlier demonstrated that men on a low-fat diet reduced prostate cancer cell growth in vitro. In the recent study, the researchers injected prostate cancer tumor cells into mice. The mice received a high-fat diet until tumors developed. Then the mice were placed in two groups, one group continued the high-fat diet and the other group was placed on a low-fat diet. Tumors began to increase in size at nine weeks for the high-fat mice compared to eighteen weeks for the low-fat mice. The high-fat mice survived for 13 weeks compared to almost 21 weeks for the low-fat group. Recognizing the need for additional research on the effect of fatty acid compositions on disease progression, the researchers said it was reasonable for men with prostate cancer to change to a low-fat diet. Source: Cancer Research 2004 via Reuters Health Information, February 25, 2004, for example, aldara mechanism. Aldara side effects - , aldara cream and alendronate.

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