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N 11 ; , obesity 150 kg body weight, n 5 ; or retro-orbital metal n 1 ; . Three 1.4 % ; patients had nondiagnostic images caused by breathing artifacts, and two did not reach submaximal heart rate, and had no traceable wall motion abnormalities. Both DSE and DSMR were successfully performed in a joint study population of 172 patients. The hemodynamic data of the joint study population are shown in Table 3. Maximum blood pressure was higher during peak stress with MR than in echocardiography P 0.01 ; . However, no significant differences were found for ratepressure product at rest or peak stress. Mean doses of dobutamine and atropine administration were similar for both modalities. Image quality at the target heart rate was assessed as: very good in 40 19.6 % ; of 204 patients with DSE and 131 69 % ; of 189 patients with DSMR P 0.001 ; good in 63 31 % ; and 25 13 %: P 0.01 ; patients respectively moderate in 83 41 % ; and 30 16 %: P 0.001 ; patients respectively nondiagnostic in 18 8.8 % ; and 3 1.6 %: P 0.001 ; patients respectively. Coronary artery disease was diagnosed in 109 of 172 patients 63.4 % ; : 39 with 1-vessel disease 25 with 2-vessel disease 45 with 3-vessel disease. The sensitivity of DSMR was 86.2 %, compared with 74.3 % for DSE, and the specificity of, because . Any two literatures or sets of titles that share a common language will have many words in common irrespective of whether the two literatures have substantial or interesting scientific linkage. Hence we must address the question of whether ARROWSMITH, in manipulating title words, really helps reveal linkage of scientific interest. The A-list consists of words that co-occur in titles with other words the Bterms ; that co-occur in titles with C-terms. The list is subjected to three filtering processes -- an extensive stoplist, a probabilistic cutoff that retains only words strongly correlated A with B and B with C ; and a category restriction. Our results at least suggest that the more important and better-established A-B and B-C biological connections tend to pass through the filters. Even though the problem of finding nuggets of value among a large number of uninteresting connections persists, the above process of enrichment appears sufficient to permit the more interesting or important connections to be spotted easily by an expert. It is also our strong impression that the high-ranking biologically-plausible A-terms lead to a more extensive and much richer B-LIST and title display in Procedure II than do words of equal a priori plausibility but which are of low rank or not on the A-list at all. We have defined the complementarity of two literatures based on the scientific arguments and discourse within those literatures, not on just shared language use. To examine and illustrate this distinction further, we developed a new A-candidate list Figure 3 ; , for the literature on Alzheimer's disease AD ; , using a restriction category based on toxins or poisons [36], and analyzed the underlying biologic connections associated with one high-rank candidate, lead. The appearance of the poisonous metal "lead" among the top-ranked words on the Alist for AD invites attention. Lead is well known as an environmental hazard with neurotoxic effects. Among the various high-ranking terms on the A-list that would seem worth investigating including ozone, ethanol, TNF tumor necrosis factor ; , IL interleukin ; , cadmium ; lead is a conspicuous and biologically-plausible choice. Even though all A-words participate in A-B-C word linkages, these linkages are not equally plausible for AD. For example, the A-B linkages for ozone tend to affect the lungs but and penicillin.
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Donald B. Beerline, M.D. 1129 Martino Road Lafayette, California 94549 Representing: American Cancer Society Term: 1996-1999 Judith Campisi, Ph.D. Department of Cancer Biology Lawrence Berkeley National Laboratory Building 70A, RM 1118 1 Cyclotron Road Berkeley, California 94720 Representing: Lawrence Berkeley National Laboratory Term: 1997-2000 James W. Covell, M.D. Department of Medicine, University of California, San Diego 9500 Gilman Drive, Bldg. BSB Rm 2004 La Jolla, California 92093 Representing: University of California, San Diego Term: 1998-2001 John W. Farquhar, M.D. Center for Research in Disease Prevention Stanford University 1000 Welch Road Stanford, California 94305 Representing: Stanford University Term: 1996-1999 Earl J. Freise, Ph.D. Mgr. Administrative Process Engineer California Institute of Technology 1200 E. California Blvd., MS 226-81 Pasadena, California 91125 Representing: California Institute of Technology Term: 1997-2000 Philip M. Gold, M.D. Department of Respiratory Care Loma Linda University Medical Center 11234 Anderson Street Loma Linda, California 92354 Representing: American Lung Association of California Term: 1997-2000 Alan C. Henderson, Dr.P.H. Health Science Department California State University, Long Beach 1250 Bellflower Boulevard Long Beach, California 90840-4902 Representing: California Department of Education Term: 1998-2001 Frederic B. Kraemer, M.D. Division of Endocrinology Stanford University Medical Center Stanford, CA 94304 Representing: American Heart Association Term: 1996-1999 Pamela Kushner, M.D. California Medical Association 2865 Atlantic Avenue, Suite 207 Long Beach, CA 90806 Representing: American Lung Association of California Term: 1998-2001 Debra Oto-Kent, M.P.H. Health Education Council 1721 2nd Street, Suite 101 Sacramento, CA 95814 Representing: Community-based Providers of Health Education and Prevention Term: 1996-1999 and phenergan and nasonex, because allergy medication. 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Apyrase and suramin partially prevented RVD: at 50 min, only 52 + 6% and 45 + 6% of the initial volume increase was offset respectively. Addition of ATP into the extracellular iso-osmotic medium induced a significant shrinkage of 12 + 2% within 4 min Figure 3 ; . - When cells were incubated in a calcium-free medium with thapsigargin, an inhibitor of calciumATPase to deplete intracellular stores, RVD was significantly abolished compared with the hypo-osmotic control. Addition of calcium at 30 min restored the RVD Figure 4 ; . To establish whether ATP contribution to cell volume regulation could be related to calcium signalling, changes in the cellular free-calcium content were assessed from the F340 F380 fluorescence ratio in fura 2-loaded cells. The fluorescence ratio was not affected by addition of iso-osmotic solution Figure 5 ; . By contrast, exposure of hepatocytes to hypoosmotic solution led to a 25% increase in cellular free-calcium content compared with the iso-osmotic value. 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