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Of the top 10 psychotropic medications prescribed to foster care children--listed on Table 3 of DSHS Study 2005--8 were under patent-protection. These drugs accounted for 80% 10261 12842 ; of the total psychotropic medications prescribed for foster children. The list includes many of the drugs in the top 16 listed above. These are: Lexapro, Zoloft, Adderall, Concerta, Depakote, Risperidal, Seroquel and Abilify. The only off-patent generic ; exceptions on the top 10 list were clonidine and trazodone. In addition, cost is accompanied by effectiveness questions as reflected in the few FDA approved indications in child psychiatric treatment. Notably, Lexapro and Zoloft primarily prescribed for the treatment of depression in youths are not approved for that indication, whereas fluoxetine available as a generic ; is approved. But the ratio of use of patented, off-label and expensive ; Lexapro and Zoloft compared to generic, labeled indication and inexpensive ; fluoxetine was approximately 5: 1. Moreover, Lexapro recently was evaluated in a double-blind, placebo-controlled DB-PC ; study Wagner et al. 2006a ; for the treatment of depression in youths and the results were negative. In addition, the DB-PC research on Zoloft for depression in youths was evaluated by the FDA and was found to be negative Shen, 2003 ; or effective only in the group of adolescents Wagner et al., 2003 ; . Seroquel and Abilify have not had such sophisticated studies in children. Topimax and Trileptal were listed among the most prescribed 16 above ; , although both have had recent negative DB-PC studies for children with bipolar disorder DelBello et al., 2005; Wagner et al., 2006b.
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Date: february 17, 2005 s leon gosselin leon gosselin chairman of the board, president and chief executive officer exhibit 9 6 certification pursuant to 17 cfr 24 13a-14 promulgated under section 302 of the sarbanes-oxley act of 2002 i, jean vezina, vice president, finance and chief financial officer of axcan pharma inc certify that: i have reviewed this annual report on form 40f of axcan pharma inc; based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report; based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the issuer as of, and for, the periods presented in this report; the registrant's other certifying officer and i are responsible for establishing and maintaining disclosure controls and procedures as defined in exchange act rules 13a-15 e ; and 15d-15 e for the issuer and we have: a ; designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the issuer, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared; b ; evaluated the effectiveness of the issuer's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and c ; disclosed in this report any change in the issuer's internal control over financial reporting that occurred during the period covered by the annual report that has materially affected, or is reasonably likely to materially affect, the issuer's internal control over financial reporting; and the issuer's other certifying officer and i have disclosed, based on our most recent evaluation of internal control over financial reporting, to the issuer's auditors and the audit committee of the issuer's board of directors or persons performing the equivalent functions ; : a ; all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the issuer's ability to record, process, summarize and report financial information; and b ; any fraud, whether or not material, that involves management or other employees who have a significant role in the issuer's internal control over financial reporting and albuterol.
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The U.S. ; National Mental Health Association 2004 ; produced a report outlining some of the best treatment programmes for young people with mental health problems in the juvenile justice system. These programmes include: Multi-Systemic Therapy MST ; : An intensive multi-modal, family-based treatment approach. Aims to empower families and young people to manage emotional and behavioural problems and cope with the social factors that are contributing to the problems. There is considerable research supporting the effectiveness of MST for young people with emotional and behavioural problems. Outcomes: rates of rearrest are reduced, and mental health problems are decreased. Functional Family Therapy FFT ; : A brief, family-centred approach to respond to the needs of young people with multiple problems and their families. Focuses on developing strengths, enhancing self-respect and encouraging positive change by giving young people and their families specific ways to improve. Research appears to support the effectiveness of FFT to reduce rates of reoffending; for example, one study showed that at five years follow-up, rates of reoffending in FFTtreated youth were only 10%. Cognitive Behavioural Therapy CBT ; : CBT works with young people to modify their thinking patterns in order to change the way that they react to challenging situations and teaches coping skills, anger management, self-control and social responsibility. CBT has been shown to be particularly effective in juvenile justice populations. Canterbury Suicide Project and alesse, for example, adderall to lose weight.
The fourth quarter was materially affected by the explosion at Arenol, which occurred on 3 August 1998. Following the explosion, Shire began rationing the shipments of Addeeall and DextroStat to wholesalers and pharmacies. Although supplies were resumed at the end of.
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MESONEPHROS. Renin is expressed very strongly from stage 13 in capillaries within glomeruli as well as in the wall of arteries in the interstitium and in the arterioles up to the aorta of the human embryonic mesonephros 630 ; . ACE protein can be detected by immunohistochemistry at stage 14 in the apical membrane of the human mesonephric tubule cells. Angiotensinogen mRNA was detected by stage 1213 in the proximal portion of the primitive tubules of the human mesonephros. The AT1 receptor mRNA was detected in human mesonephric glomeruli, probably in mesangial cells, beginning at stage 12, and the AT2 receptor mRNA was the component to be expressed first stage 11 ; and was confined to the undifferentiated mesenchyme of the human mesonephros surrounding the preliminary tubules and glomeruli. In addition, both the mRNA and protein for AT1 and AT2 receptors were present in the ovine fetal mesonephri 69 ; . B ; METANEPHROS. The distribution of renin mRNA in human metanephros appeared slightly different from that in the mesonephros as it had become confined to the juxtaglomerular apparatus at the vascular pole of the glomerulus and to dispersed cells of arteries located next to glomeruli. In human metanephros, ACE activity was detected in proximal convoluted tubules and collecting ducts in increasing amounts until birth 630 ; . In the human metanephros, angiotensinogen mRNA showed only weak labeling macroscopically and was expressed in proximal tubules from 8 wk of and throughout gestation. Hybridization signal for AT1 receptor mRNA was observed in human metanephros glomeruli and in proximal tubular epithelium. Juxtaglomerular cells expressed AT1 mRNA as soon as they differentiated. AT2 receptor mRNA and allopurinol.
Pharmacology and Therapeutics Department, Lagos State University College of Medicine, P.M.B. 21266, Ikeja, Lagos, Nigeria 2 Resident in Community Medicine and Primary Health Care, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria.
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Four. 1. 2. The respondent did not complete a physical or history of this patient, an adult male. In the course of treatment for Patient Number Four, the respondent prescribed human growth hormone in the form of Norditropin, Profasi, Clomid, Adderall, Valium, testosterone, Lonamin and Adipex. The respondent did not do any lab tests prior to initiating hormone growth therapy. The respondent prescribed testosterone to Patient Number Four in an amount that is three times the appropriate dose. The respondent's treatment of Patient Number Four deviated from the standard of care in the following ways: a ; The respondent prescribed human growth hormone without adequate testing with a proper provocative test. b ; The respondent prescribed Norditropin for the patient when this is not approved for use in adults. c ; The respondent treated the patient for testosterone deficiency without determining whether there was a primary or secondary testosterone deficiency and she prescribed testosterone to the patient in an excessive amount. d ; The respondent prescribed both human growth hormone and Adderall, an amphetamine, Valium, Ionamin, Adipex, Profasi, and Clomid without any indication in the patient's record for the need of these drugs. Nothing in the patient's file addresses the need for these medications and alphagan.
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Degenerative spine changes in younger women and 2 ; bone loss occurs faster in the spine than in the hip and thus allows earlier detection of osteoporosis 2 ; . The NOF recommends BMD testing in women aged 65 years regardless of risk factors, younger postmenopausal women with 1 risk factor, and all postmenopausal women with fracture. WHEN TO MEASURE BMD: GUIDELINES FROM AACE, NAMS, NOF The AACE guidelines identify 3 categories of women who may benefit from pharmacologic treatment: women with postmenopausal osteoporosis e.g., those with low-trauma fracture or low BMD ; , women with borderline-low BMD T-scores -1.5 ; if risk factors are present, and women in whom nonpharmacologic therapy has been demonstrated to be inadequate for preventing bone loss or fracture 1 ; . The NAMS guidelines are somewhat more conservative than the AACE guidelines in identifying patients who require treatment. Treatment is recommended in all postmenopausal women with prior vertebral or hip fracture or with total hip or spine Tscores -2.5 and in postmenopausal women with total hip or spine T-scores from -2.0 to -2.5 and 1 additional risk factor 1, 2 ; . According to NOF, therapy should be initiated in women with T-scores -2.0 by hip DXA with no risk factors, those with T-scores -1.5 and 1 risk factor, and all patients with a prior vertebral or hip fracture 3 ; . OVERVIEW: TREATMENT OF BONE DISEASE Osteoporosis responds to treatment. In addition to lifestyle changes such as improved diet and increased exercise, there are a number of effective, well-tolerat, for example, adderall and ritalin.
We are frustrated by TRICARE's abysmal reimbursement. Most doctors in this geographic area are not [TRICARE] providers because of this. We fought with TRICARE over depoprovera coverage. I have to buy 96 units of depo to get the lowest price of $41.20 each. TRICARE pays $45 plus $12 copay. What business can survive with such a narrow profit margin? TRICARE is the worst payer for depoprovera. [TRICARE] used to pay $31 [each], and I almost dropped my provider status over this. I feel military personnel should get the drugs prescribed at no cost to them. When I was in active duty, I served in the P&T committee and we were responsive to patient needs and costs; it worked well. But managed care P&T committees are dishonest, and I cannot deal with the myriad formularies shoved my way. I have never seen a TRICARE formulary. As a fertility specialist, it does not make sense to me that TRICARE patients can have certain fertility drugs or treatment only if they are seen at a base facility. The drugs should be covered wherever the patient is seen if they need it. I don't have a problem with a tiered co-pay for medications, but I have a real problem with a formulary that won't pay any of the cost of a medication when other less-expensive medications have been tried and failed. The main examples are Concerta or Metadate, Adderall, Diflucan, Xapenex, and Pulmicort not just with TRICARE, but in general ; , and some formularies won't pay for any antidepressants that I prescribe for my adolescent patients; [then] the patient has to see a psychiatrist and altace.
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D. DISLOCATIONS General * Check movement, pulses, sensation distal to injury. * If circulation and neurological signs normal, immobilize the involved joints proximal and distal to injury, in position of greatest comfort. If impaired request helicopter evacuation. Shoulder dislocation * Attempt anterior shoulder dislocation reduction if a ; patient evacuation to hospital will take 6 hr, b ; no signs of midshaft fracture present, and c ; dislocation occurred within last 4 hours. * Contact medical command if possible. * a ; Have patient lie face down on a rock, log, or other platform and allow the affected arm to dangle down with 10-15lb weight on wrist or upper arm see appendix P ; . b ; The patient is told to relax and eventually spontaneous reduction may occur about 1 hour ; . c ; After reduction, immobilize arm with sling and swathe, check neurovascular status see appendix P ; . Patella dislocation * Attempt patella reduction if a ; pt evacuation to hospital 6 hr, and b ; injury occurred within 2 hours. * Flex hip and apply gentle traction that slowly extends the knee while gently pushing the patella back into its normal position. * Immobilize knee in extended position from the ankle to the groin and repeat neurological and circulatory status. Knee dislocation * Check distal pulses, circulation and neurological status. * Attempt knee dislocation reduction only if no distal pulses present with poor capillary refill or distal neurological deficits. First attempt contact with Medical Command. * One person stabilizes the femur proximal to the knee. * Second person applies in-line traction on the lower leg. * Repeat neurovascular checks and periodically check for compartment syndrome see appendix B ; . * Splint leg with approximately 15o of flexion. * Request helicopter evacuation. Hip dislocation and fracture. * Check distal pulses, circulation, and neurological status. * Buddy splint legs together after padding. When available, apply traction device for femur fractures. * Request helicopter evacuation. E. NECK SPINE INJURIES * In case of high-velocity impact e.g., fall greater than 15', aircraft crash, motor vehicle accidents ; head injury with altered consciousness, unconsciousness associated with trauma, severe facial trauma, any sign or symptom of spine injury abnormal motor or sensory function, numbness, spine tenderness or pain on neck or back, tingling ; , or unknown mechanism of injury, then assume spinal cord injury. * Maintain cervical neutrality on patient's head. * Apply a stiff cervical collar, if available. Do not hyperextend neck. If not, use available materials to stabilize and ambien and adderall, for instance, adderalll sale.
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Home articles health topics diseases & conditions tests & procedures drugs & supplements symptoms site map quick links adhd adhd treatment adhd medications adult adhd adderall ritalin strattera concerta focalin daytrana adderall xr articles: about adult adhd - adhd and injuries adhd this emedtv article offers an in-depth discussion of the symptoms, diagnosis and treatment of adhd - a common childhood condition characterized by inattention, fidgeting, and lack of organization and amitriptyline.
Generic Name Amphetamine mixed salts Dextroamphetamine 6 to 8 Hour 8 Hour Adderall, NA high dose Dexedrine NA Spansule Methylphenidate Ritalin-SR Concerta Metadate-ER Methylin-ER Pemoline NA NA Cylert a Abbreviations: ER extended release, NA not applicable, SR sustained release. 4 Hour Adderall, low dose Dexedrine DextroStat Ritalin.
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Gros P, Nenah Y, Croop J, and Housman D. Isolation and expression of a complementary DNA that confers multidmg resistance. Nature- 3233: 728-731 1986a ; Gros P, Croop J, Roninson 1, Varshavsky A, and Housman D. Isolation and characterization of DNA sequences arnplified in muitidrug-resistant hamster cells. Proc Nad Acad Sci USA. 83: 337-341 1986b ; Gros P, Croop J, and Housman D. Mammalian multidnig resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell. 47: 371-380 1986~.
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Stimulants such as amphetamine dexedrine, adderall and methylphenidate ritalin have been used for over 50 years in the treatment of children with.
FINANCIAL RESULTS FOR THE QUARTER ENDED 31 MARCH 2000 Overview of financial results Group revenues for the first quarter increased by 25 per cent to $119.0 million Q1 1999: $95.3 million ; . The Group recorded income before tax and APB 25 charge of $26.7 million Q1 1999: $19.1 million ; and basic earnings per ordinary share pre APB 25 charge of 7.7 cents or 23.1 cents per ADS Q1 1999: 6.3 cents or 18.9 cents per ADS ; . The net loss after APB25 charge ; was $4.3 million Q1 1999: net income of $10.3 million ; . Basic loss per ordinary share was 1.7 ; cents or 5.1 ; cents per ADS Q1 1999: basic earnings per share 4.3 cents or 12.8 cents per ADS ; . Sales and marketing Product sales represented 95 per cent of total revenues at $113.2 million, an increase of 29 per cent over Q1 1999 product sales of $87.8 million. First quarter sales of Xdderall and DextroStat were $56.9 million, representing growth of 70 per cent over Q1 1999. Shire gained 32.8 per cent of prescriptions written for Attention Deficit Hyperactivity Disorder ADHD ; in the US compared to 22.1 per cent at 31 March 1999 and 30.5 per cent at 31 December 1999. Sales of Agrylin, the only US product licensed for the treatment of essential thrombocythemia, continued to grow strongly, reaching $11.0 million, a 113 per cent increase over Q1 1999 sales of $5.2 million. Shire achieved a script share of 14.3 per cent at 31 March 2000 of the total US Agrylin market, including Hydrea and generic hydroxyurea, compared to 10.0 per cent at 31 March 1999 Sales of Pentasa, at $10.3 million, were 31 per cent lower than the comparable period last year, when sales were higher due to wholesaler stockbuilding. Prescriptions for Pentasa increased by 10.5 per cent during the quarter and reached a script share of 18.0 per cent of the US oral mesalamine market at 31 March 2000, compared to 17.6 per cent at 31 March 1999 Carbatrol recorded sales growth of 115 per cent from sales of $2.6 million in Q1 1999 to $5.6 million in Q1 2000. This translates to 26 per cent of the US extended release carbamazepine prescription market at the end of March 2000, compared to 12.4 per cent at 31 March 1999. Sales of Shire's lead UK product, the Calcichew range, were maintained at $4.0 million, with a UK prescription market share of 71 per cent at the end of February 2000. Licensing Licensing and development fees in this quarter decreased by 23 per cent to $4.9 million 1999: $6.4 million ; . These results reflect the variability of this income quarter on quarter, based as it is milestone payments and the development status of relevant projects, in particular Reminyl. Royalties were $0.6 million 1999: $0.6 million.
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Q: Do you consider Provigil as a first-line agent for the treatment of narcolepsy? A: Yes. It is effective, works very well with once a day dosing in many patients, and can be prescribed as a Schedule IV drug with refills which can be more convenient than Schedule II drugs. As most narcoleptic patients are young, once a day dosing seems to improve compliance. It also tends to work better in patients with milder narcolepsy. However, the major downside of Provigil is cost. Metadate CD is another good first line alternative but some patients may need BID or even TID dosing negating the QD advantage and cost-savings. I would not use pemoline given its potential for liver toxicity and the availability of safer alternatives. Q: Which CNS stimulant would you start a newly diagnosed narcolepsy patient on and why? A: I would try to find a "once a day" solution and failing that, a "twice a day" solution. Patients do have Individual tolerances for the different stimulant medication preparations, and it does make sense to Try other preparations if side effects are limiting compliance or a certain preparation is relatively ineffective. Q: Should stimulant medications be used in sleep apnea patients? A: Possibly. There are patients who have sleep apnea and narcolepsy or who despite using CPAP and getting enough night time sleep, are still tired during the day. Use of a stimulant medication may be appropriate for these patients, however use caution. Many sleep apnea patients are noncompliant with CPAP and this should be assessed with a computer read out of CPAP use which can be done by the patient's home care company. The patient should also be getting enough sleep at night, and should not be on other medications that cause drowsiness or interfere with sleep. Referral to a sleep specialist is suggested. Medication Cost Comparison Drug Regimen Aderall BID dosing Afderall XR QD dosing Concerta 36mg QD Cylert 37.5mg QD Cylert 75mg QD Dexadrine 5mg BID Dexadrine Spansules 10mg QD Focalin 5mg BID Focalin 10mg BID Metadate CD 20mg QD Metadate CD 20mg BID Metadate CD 30mg QD Provigil 200mg QD Provigil 200mg BID Ritalin 10mg TID Ritalin 20mg BID Ritalin SR 20mg BID Ritalin LA 40mg QD.
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